NCT00327509

Completed

mRNA Expression in Lymphocytes of Glaucoma Patients

University Hospital, Basel, Switzerland Source

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Other study identifiers

Sponsor study identifier

004-KAR-2004-001

Study Type

observational

Actual enrollment (reported)

60

Locations

1 country

Sites

1

Timeline

Study Start

January 2004

Date type not reported

This date has not been verified as actual or estimated.

Primary Completion

December 2007

Actual (reported)

Study Completion

December 2007

Actual (reported)

Brief Summary

The aim of the study is to compare messenger ribonucleic acid (mRNA) expression of various genes in lymphocytes between glaucoma patients and sex and age-matched healthy subjects. A secondary objective is to analyze the impact of different forms of glaucoma or of a vasospastic propensity on the findings.

Registry Overview

Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.

Recruitment status: completed
Actual enrollment (reported): 60 participants
Study completion date: December 2007
Actual (reported)
Listed locations: 1 countries · 1 sites

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.

Study Start
January 2004
Date type not reported
This date has not been verified as actual or estimated.
First Submitted
May 17, 2006
Actual (reported)
First Posted
May 18, 2006
Actual (reported)
Primary Completion
December 2007
Actual (reported)
Study Completion
December 2007
Actual (reported)

Last Updated: August 20, 2009
Status Verified: August 2009
Last Update Submitted: August 19, 2009

Conditions

Glaucoma Healthy Subjects

Keywords

mRNAglaucoma

Study Arms (6)

1-HTG

high tension glaucoma highest IOP \> 21 mmHg

2-NTG

normal tension glaucoma highest measured IOP \< 21 mmHg

3-PEX

pseudoexfoliation glaucoma PEX material visible

4-Juvenile

juvenile glaucoma

5-Control1

healthy subjects (age group 1)

6-Control2

healthy subjects (age group 2)

Eligibility Criteria

Age18 Years - 85 Years

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodProbability Sample

Study Population

glaucoma patients, healthy subjects

You may qualify if:

Glaucoma patients

Sponsors & Collaborators

University of Bonn
Othercollaborator
University Hospital, Basel, Switzerland
Otherlead

Study Sites (1)

University Hospital Basel, Eye Clinic

Basel, Canton of Basel-City, 4031, Switzerland

Biospecimen

Retention: SAMPLES WITH DNA

white cells

MeSH Terms

Conditions

Glaucoma

Condition Hierarchy (Ancestors)

Ocular HypertensionEye Diseases

Study Officials

Selim Orgül, MD
University Hospital, Basel, Switzerland
STUDY DIRECTOR

Enrollment

60 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: CASE CONTROL
Time Perspective: PROSPECTIVE
Sponsor Type: OTHER

Study Record Dates

First Submitted

May 17, 2006

First Posted

May 18, 2006

Study Start

January 2004

Date type not reported

This date has not been verified as actual or estimated.

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diagnosis of chronic glaucoma with typical glaucomatous disc and visual field damage

a present or past diurnal tension curve with an average intraocular pressure above 21 mmHg without treatment HTG)

a present or past diurnal tension curve with an average intraocular pressure below 21 mmHg without treatment (NTG)

a present or past diurnal tension curve with an average intraocular pressure above 21 mmHg without treatment and signs of pseudoexfoliation in the anterior segment (PEX)

a juvenile-onset open-angle glaucoma with a present or past diurnal tension curve with an average intraocular pressure above 21 mmHg without treatment (Juvenile Glaucoma)

Healthy subjects

no history of ocular disease

no history of systemic disease

no history of alcohol/drug abuse

normal blood pressure (100-140 / 60-90 mmHg)

best corrected visual acuity above 20/25 in both eyes

no pathological findings upon a slit-lamp examination and indirect fundoscopy

IOP \< 20 mmHg in both eyes

You may not qualify if:

Ametropia \> 3 dpt
Iridocorneal angle extremely narrow with complete or partial closure as determined by gonioscopy
Pigmentary dispersion
any abnormality which in the physician's view would prevent reliable applanation tonometry
History of chronic or recurrent severe inflammatory eye disease such as scleritis or uveitis
History of ocular trauma or intraocular surgery within the past 6 months
History of infection or inflammation within the past 3 months
History of clinically significant or progressive retinal disease such as retinal degeneration, diabetic retinopathy or retinal detachment
Need for any concomitant medications that may interfere with the evaluation of ocular blood flow
significant history and/or active alcohol or drug abuse

Contact the study team to confirm eligibility.

Primary Completion

December 2007

Actual (reported)

Study Completion

December 2007

Actual (reported)

Last Updated

August 20, 2009

Record last verified: 2009-08

Source record

Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.

Source: ClinicalTrials.gov.

JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.

Registry identifier: NCT00327509
Data provider: ClinicalTrials.gov
Source updated: 2009-08-20
Normalization version: ctgov-legacy-1

Open registry record

Source retrieved: 2026-10-25 22:32:19 UTC

Locations

CH(1)

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Study Arms (6)

1-HTG

2-NTG

3-PEX

4-Juvenile

5-Control1

6-Control2

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Biospecimen

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations