mRNA Expression in Lymphocytes of Glaucoma Patients

NCT00327509 | Completed

• 1 other identifier: 004-KAR-2004-001
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of the study is to compare messenger ribonucleic acid (mRNA) expression of various genes in lymphocytes between glaucoma patients and sex and age-matched healthy subjects. A secondary objective is to analyze the impact of different forms of glaucoma or of a vasospastic propensity on the findings.

Conditions

Glaucoma; Healthy Subjects

Keywords

mRNA; glaucoma

Study Arms (6)

1-HTG

high tension glaucoma highest IOP \> 21 mmHg

2-NTG

normal tension glaucoma highest measured IOP \< 21 mmHg

3-PEX

pseudoexfoliation glaucoma PEX material visible

4-Juvenile

juvenile glaucoma

5-Control1

healthy subjects (age group 1)

6-Control2

healthy subjects (age group 2)

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

glaucoma patients, healthy subjects

You may qualify if:

• Glaucoma patients
• diagnosis of chronic glaucoma with typical glaucomatous disc and visual field damage
• a present or past diurnal tension curve with an average intraocular pressure above 21 mmHg without treatment HTG)
• a present or past diurnal tension curve with an average intraocular pressure below 21 mmHg without treatment (NTG)
• a present or past diurnal tension curve with an average intraocular pressure above 21 mmHg without treatment and signs of pseudoexfoliation in the anterior segment (PEX)
• a juvenile-onset open-angle glaucoma with a present or past diurnal tension curve with an average intraocular pressure above 21 mmHg without treatment (Juvenile Glaucoma)
• Healthy subjects
• no history of ocular disease
• no history of systemic disease
• no history of alcohol/drug abuse
• normal blood pressure (100-140 / 60-90 mmHg)
• best corrected visual acuity above 20/25 in both eyes
• no pathological findings upon a slit-lamp examination and indirect fundoscopy
• IOP \< 20 mmHg in both eyes

You may not qualify if:

• Ametropia \> 3 dpt
• Iridocorneal angle extremely narrow with complete or partial closure as determined by gonioscopy
• Pigmentary dispersion
• any abnormality which in the physician's view would prevent reliable applanation tonometry
• History of chronic or recurrent severe inflammatory eye disease such as scleritis or uveitis
• History of ocular trauma or intraocular surgery within the past 6 months
• History of infection or inflammation within the past 3 months
• History of clinically significant or progressive retinal disease such as retinal degeneration, diabetic retinopathy or retinal detachment
• Need for any concomitant medications that may interfere with the evaluation of ocular blood flow
• significant history and/or active alcohol or drug abuse

Sponsors & Collaborators

• University Hospital, Basel, Switzerland: lead
• University of Bonn: collaborator

Study Sites (1)

University Hospital Basel, Eye Clinic

Basel, Canton of Basel-City, 4031, Switzerland

Location

Biospecimen

Retention: SAMPLES WITH DNA

white cells

MeSH Terms

Conditions

Glaucoma

Condition Hierarchy (Ancestors)

Ocular Hypertension; Eye Diseases

Study Officials

• Selim Orgül, MD

  University Hospital, Basel, Switzerland

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: May 17, 2006
• First Posted: May 18, 2006
• Study Start: January 1, 2004
• Primary Completion: December 1, 2007
• Study Completion: December 1, 2007
• Last Updated: August 20, 2009

Record last verified: 2009-08

Locations

CH (1)