NCT00304824

Completed

Assessment of the Ability to Distinguish Odors in Glaucoma P...

University Hospital, Basel, Switzerland Source

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Other study identifiers

Sponsor study identifier

009-Guk-2004-002

Study Type

observational

Actual enrollment (reported)

30

Locations

0 countries

Sites

N/A

Timeline

Study Start

October 2004

Date type not reported

This date has not been verified as actual or estimated.

Primary Completion

Not reported

Date not reported

Study Completion

November 2005

Actual (reported)

Brief Summary

Glaucoma is one of the leading causes of blindness worldwide. The key feature of glaucoma is damage to the optic nerve head with loss of retinal ganglion cells and local tissue remodeling. Neuronal cell death in glaucoma occurs by apoptotic mechanisms1. Apoptosis of neurons also plays a major role in neurodegenerative diseases, such as Alzheimer's or Parkinson's disease. An association between glaucoma and these disorders has been described 2-4. Furthermore, it has been reported that the olfactory function is disturbed in these neurodegenerative diseases5-6. We hypothesize that similar olfactory alterations may occur in glaucoma which is in fact a local neurodegenerative disease.

Registry Overview

Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.

Recruitment status: completed
Actual enrollment (reported): 30 participants
Study completion date: November 2005
Actual (reported)
Listed locations: 0 countries · 0 sites

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.

Study Start
October 2004
Date type not reported
This date has not been verified as actual or estimated.
Study Completion
November 2005
Actual (reported)
First Submitted
March 17, 2006
Actual (reported)
First Posted
March 20, 2006
Actual (reported)

Last Updated: September 26, 2008
Status Verified: September 2008
Last Update Submitted: September 25, 2008

Conditions

Glaucoma

Keywords

GlaucomaOlfactory functionsSniffing Sticks Test

Eligibility Criteria

Age17 Years - 70 Years

Sexall

Healthy VolunteersNo

Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

Sampling MethodNon-Probability Sample

Study Population

glaucoma patients

You may qualify if:

Chronic open-angle glaucoma with typical glaucomatous disc and visual field damage.

You may not qualify if:

Occludable iridocorneal angles
History of current, chronic or recurrent inflammatory eye disease
History of retinal or neuroophthalmologic disease that could result in visual field defects

Sponsors & Collaborators

University Hospital, Basel, Switzerland
Otherlead

MeSH Terms

Conditions

Glaucoma

Condition Hierarchy (Ancestors)

Ocular HypertensionEye Diseases

Study Officials

Selim Orgul
University Eye Hospital Basel, Switzerland
STUDY DIRECTOR

Enrollment

30 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: CASE ONLY
Time Perspective: PROSPECTIVE
Sponsor Type: OTHER

Study Record Dates

First Submitted

March 17, 2006

First Posted

March 20, 2006

Study Start

October 2004

Date type not reported

This date has not been verified as actual or estimated.

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Need for any concomitant medications that may interfere with the evaluation of olfactory function

Patients with a significant history and/or active alcohol or drug abuse (significant is defined as that which in the opinion of the investigator may either put the patient at risk because of participation in the study or may influence the results of the study or the patient's ability to participate in the study), smokers

History of olfactory disturbance related to identifiable local factors and any local condition that could lead to hyposmia/anosmia or interfere with the olfactory function, such as polyps, chronic sinus infection, sub(acute) viral or bacterial infection, history of sinus surgery

Contact the study team to confirm eligibility.

Study Completion

November 2005

Actual (reported)

Last Updated

September 26, 2008

Record last verified: 2008-09

Source record

Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.

Source: ClinicalTrials.gov.

JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.

Registry identifier: NCT00304824
Data provider: ClinicalTrials.gov
Source updated: 2008-09-26
Normalization version: ctgov-legacy-1

Open registry record

Source retrieved: 2026-10-25 22:19:15 UTC

Assessment of the Ability to Distinguish Odors in Glaucoma Patients

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

Study Completion

First Submitted

First Posted

Conditions

Keywords

Eligibility Criteria

You may qualify if:

You may not qualify if:

Sponsors & Collaborators

Related Links

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

Source record

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

Study Completion

First Submitted

First Posted

Conditions

Keywords

Eligibility Criteria

You may qualify if:

You may not qualify if:

Sponsors & Collaborators

Related Links

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

Source record