NCT00430274

Completed

Photographic Imaging of the Retina and Optic Nerve Head of G...

Selim Orguel Source

Other study identifiers

Sponsor study identifier

073-GRM-2006-001

Study Type

observational

Actual enrollment (reported)

120

Locations

1 country

Sites

1

Timeline

Study Start

January 2006

Date type not reported

This date has not been verified as actual or estimated.

Primary Completion

August 2009

Actual (reported)

Study Completion

April 2017

Actual (reported)

Brief Summary

Retinal structures are difficult to visualize because the retina is optically transparent. In glaucoma, the microglia in the retina becomes activated in eyes with glaucomatous damage. The microglia forms a dense meshwork which resembles gliosis-like alterations, which may increase light scattering. With appropriate technology, increased reflection and light scattering from the retina may be detected in eyes of glaucoma patients. In this study, we investigate whether clinically observable retinal gliosis-like alterations occur more often in patients with glaucoma than in non-glaucomatous controls, and whether gliosis-like alterations are associated with a vasospastic propensity.

Registry Overview

Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.

Recruitment status: completed
Actual enrollment (reported): 120 participants
Study completion date: April 2017
Actual (reported)
Listed locations: 1 countries · 1 sites

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.

Study Start
January 2006
Date type not reported
This date has not been verified as actual or estimated.
First Submitted
January 31, 2007
Actual (reported)
First Posted
February 1, 2007
Actual (reported)
Primary Completion
August 2009
Actual (reported)
Study Completion
April 2017
Actual (reported)

Last Updated: August 25, 2017
Status Verified: August 2017
Last Update Submitted: August 24, 2017

Conditions

Glaucoma

Keywords

glaucomaretinal gliosis-like alterationsoptical coherence tomographyautomated microperimetry

Eligibility Criteria

Age45 Years - 80 Years

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodNon-Probability Sample

Study Population

patients with vascular dysregulation

You may qualify if:

For NTG patients :
untreated intraocular pressure equal to or less than 21mmHg or
median intraocular pressure equal to or less than 20mmHg
For HTG patients:
mean untreated intraocular pressure more than 21mmHg

Sponsors & Collaborators

Selim Orguel
Otherlead

Study Sites (1)

University Eye Clinic

Basel, 4031, Switzerland

MeSH Terms

Conditions

Glaucoma

Condition Hierarchy (Ancestors)

Ocular HypertensionEye Diseases

Study Officials

Selim Orgül, MD
University Eye Clinic Basel
STUDY DIRECTOR

Enrollment

120 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: CASE ONLY
Time Perspective: PROSPECTIVE
Sponsor Type: OTHER
Responsible Party: SPONSOR INVESTIGATOR
PI Title: Prof. Dr.

Study Record Dates

First Submitted

January 31, 2007

First Posted

February 1, 2007

Study Start

January 2006

Date type not reported

This date has not been verified as actual or estimated.

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For both:

open drainage angles on gonioscopy

typical optic disc damage with glaucomatous cupping and thinning of neuroretinal rim

absence of any secondary cause for a glaucomatous optic neuropathy

visual field defects congruent to glaucomatous disc damage (disc/field correlation)

Healthy subjects:

no history of ocular diseases

no current topical medication

no drug or alcohol abuse

best corrected visual acuity above 20/25 in both eyes

+2 more criteria

You may not qualify if:

For NTG and HTG patients:
any other form of retinal or neuroophthalmological disease that could cause gliosis-like retinal alterations or result in visual field defects
history of chronic or recurrent severe inflammatory eye disease
history of ocular trauma or intraocular surgery
history of infection or inflammation within the past 3 months
history and clinical evidence for other retinal disease

Contact the study team to confirm eligibility.

Primary Completion

August 2009

Actual (reported)

Study Completion

April 2017

Actual (reported)

Last Updated

August 25, 2017

Record last verified: 2017-08

Data Sharing

IPD Sharing: Will not share

Source record

Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.

Source: ClinicalTrials.gov.

JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.

Registry identifier: NCT00430274
Data provider: ClinicalTrials.gov
Source updated: 2017-08-25
Normalization version: ctgov-legacy-1

Open registry record

Source retrieved: 2026-10-25 22:29:47 UTC

Locations

CH(1)

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations