Photographic Imaging of the Retina and Optic Nerve Head of Glaucoma Patients and Normal Controls

NCT00430274 | Completed

• 1 other identifier: 073-GRM-2006-001
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

Retinal structures are difficult to visualize because the retina is optically transparent. In glaucoma, the microglia in the retina becomes activated in eyes with glaucomatous damage. The microglia forms a dense meshwork which resembles gliosis-like alterations, which may increase light scattering. With appropriate technology, increased reflection and light scattering from the retina may be detected in eyes of glaucoma patients. In this study, we investigate whether clinically observable retinal gliosis-like alterations occur more often in patients with glaucoma than in non-glaucomatous controls, and whether gliosis-like alterations are associated with a vasospastic propensity.

Conditions

Glaucoma

Keywords

glaucoma; retinal gliosis-like alterations; optical coherence tomography; automated microperimetry

Eligibility Criteria

• Age: 45 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients with vascular dysregulation

You may qualify if:

• For NTG patients :
• untreated intraocular pressure equal to or less than 21mmHg or
• median intraocular pressure equal to or less than 20mmHg
• For HTG patients:
• mean untreated intraocular pressure more than 21mmHg
• For both:
• open drainage angles on gonioscopy
• typical optic disc damage with glaucomatous cupping and thinning of neuroretinal rim
• absence of any secondary cause for a glaucomatous optic neuropathy
• visual field defects congruent to glaucomatous disc damage (disc/field correlation)
• Healthy subjects:
• no history of ocular diseases
• no current topical medication
• no drug or alcohol abuse
• best corrected visual acuity above 20/25 in both eyes

You may not qualify if:

• For NTG and HTG patients:
• any other form of retinal or neuroophthalmological disease that could cause gliosis-like retinal alterations or result in visual field defects
• history of chronic or recurrent severe inflammatory eye disease
• history of ocular trauma or intraocular surgery
• history of infection or inflammation within the past 3 months
• history and clinical evidence for other retinal disease

Sponsors & Collaborators

• Selim Orguel: lead

Study Sites (1)

University Eye Clinic

Basel, 4031, Switzerland

Location

MeSH Terms

Conditions

Glaucoma

Condition Hierarchy (Ancestors)

Ocular Hypertension; Eye Diseases

Study Officials

• Selim Orgül, MD

  University Eye Clinic Basel

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Prof. Dr.

Study Record Dates

• First Submitted: January 31, 2007
• First Posted: February 1, 2007
• Study Start: January 1, 2006
• Primary Completion: August 1, 2009
• Study Completion: April 1, 2017
• Last Updated: August 25, 2017

Record last verified: 2017-08

Data Sharing

• IPD Sharing: Will not share

Locations

CH (1)