Analysis of Clinical Profiles of Chinese Patients With Normal Tension Glaucoma

NCT00321386 | Unknown DMC

• 2 other identifiers: KC/KE 05-0169/ER-1CRE-2005.434
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 2

Brief Summary

To obtain demographic and baseline ophthalmic parameters (such as Intraocular Pressure profiles, disc morphological characteristics, central corneal thickness, peripapillary retinal nerve fibre layer thickness and its serial changes, visual field changes, severity of any medical associations-e.g. hypertension, migraine, strokes, silent cerebral infarcts) with non-invasive measurements, in Chinese Patients with Normal Tension Glaucoma

Conditions

Glaucoma

Keywords

Glaucoma; Open Angle; Normal Tension

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with Normal Tension Glaucoma recruited from a teritary University Eye Hospital setting.

You may qualify if:

• All Chinese patients with age\>18 years old with Normal Tension Glaucoma will be recruited

You may not qualify if:

• Diseases that precluded accurate measurement of IOP, visual acuity, retinal nerve fiber layer thickness, and visual field tests.

Sponsors & Collaborators

• Chinese University of Hong Kong: lead
• Hong Kong Eye Hospital: collaborator
• Prince of Wales Hospital, Shatin, Hong Kong: collaborator

Study Sites (2)

Hong Kong Eye Hospital

Hong Kong, Hong Kong

RECRUITING

Prince of Wales Hospital

Hong Kong, Hong Kong

RECRUITING

Related Publications (5)

• Drance S, Anderson DR, Schulzer M; Collaborative Normal-Tension Glaucoma Study Group. Risk factors for progression of visual field abnormalities in normal-tension glaucoma. Am J Ophthalmol. 2001 Jun;131(6):699-708. doi: 10.1016/s0002-9394(01)00964-3.

  PMID: 11384564 BACKGROUND

• Leung DY, Tham CC, Li FC, Kwong YY, Chi SC, Lam DS. Silent cerebral infarct and visual field progression in newly diagnosed normal-tension glaucoma: a cohort study. Ophthalmology. 2009 Jul;116(7):1250-6. doi: 10.1016/j.ophtha.2009.02.003. Epub 2009 May 30.

  PMID: 19481813 RESULT

• Leung DY, Li FC, Kwong YY, Tham CC, Chi SC, Lam DS. Simvastatin and disease stabilization in normal tension glaucoma: a cohort study. Ophthalmology. 2010 Mar;117(3):471-6. doi: 10.1016/j.ophtha.2009.08.016. Epub 2010 Jan 4.

  PMID: 20045568 RESULT

• Leung DY, Kwong YY, Li FC, Tham CC, Chi SC, Lam DS. Comparison of the clinical characteristics of normal tension glaucoma patients with pretreatment intraocular pressures in the high-teens and low-teens. Br J Ophthalmol. 2010 May;94(5):663-5. doi: 10.1136/bjo.2009.163014. No abstract available.

  PMID: 20447973 RESULT

• Leung DY, Iliev ME, Chan P, Baig N, Chi SC, Tham CC, Lam DS. Pressure-cornea-vascular index (PCVI) for predicting disease progression in normal tension glaucoma. Br J Ophthalmol. 2011 Aug;95(8):1106-10. doi: 10.1136/bjo.2009.175992. Epub 2010 Aug 7.

  PMID: 20693562 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Blood taking for glaucoma genetics analysis shall be performed.

MeSH Terms

Conditions

Glaucoma

Condition Hierarchy (Ancestors)

Ocular Hypertension; Eye Diseases

Study Officials

• LEUNG YL Dexter, MBChB, FRCS

  Glaucoma Service, Hong Kong Eye Hospital

  PRINCIPAL INVESTIGATOR

• LAM SC Dennis, MD, FRCOphth

  Chinese University of Hong Kong

  STUDY CHAIR

Central Study Contacts

LEUNG YL Dexter, MBChB, FRCS

CONTACT

852-27623000; dexleung@alumni.cuhk.net

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: May 1, 2006
• First Posted: May 3, 2006
• Study Start: December 1, 2003
• Primary Completion: December 1, 2008
• Study Completion: December 1, 2012
• Last Updated: June 28, 2011

Record last verified: 2011-06

Locations

HK (2)