Psychopathology of Normal-tension Glaucoma in Hong Kong Chinese Out-patient

NCT00324181 | Unknown DMC

• 1 other identifier: CRE-2006.060
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

It is suggested the pathogenesis of normal-tension glaucoma (NTG) involves vascular dysregulation. In the past studies, it is well documented that many physical problems related to vascular dysregulation, such as angina pectoris (Friedman M et al 1974; Russek HI et al 1976), migraine (Diener HC et al 1994), primary Raynaud's disease (Wagner HH et al 1993) and stroke (Gainotti G, et al, 2001; Hayee Ma et al 2001), are associated with a high risk of depressive illness. So, NTG, being a disease involving vascular dysregulation, is postulated to be associated with psychopathology. Glaucoma increases after 40 year-old and the number of people over this age in Hong Kong is rapidly growing. However, we have no knowledge about the link between psychopathology and NTG in Hong Kong. The present study is sought to overcome the limitation in previous research and the goals of present study are:

• To identify the prevalence of psychopathology of normal-tension glaucoma Hong Kong Chinese Out-patients attending a university-affiliated glaucoma clinic.
• To determine whether there are any differences among NTG patients, patients with glaucoma other than NTG and control in terms of psychopathology and quality of life. Designs: Case-control study to compare among patients with normal-tension glaucoma (NTG), patients with glaucoma other than normal-tension glaucoma (OTNTG) and control in terms of psychopathology and quality of life

Conditions

Glaucoma

Keywords

normal-tension glaucoma; psychopathology; Hong Kong

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Glaucoma patients from a tertiary University Ophthalmic clinic setting

You may qualify if:

• Cantonese-speaking Chinese
• Aged from 18 to 65
• Those just receiving routine fundi examination without any ophthalmologic follow-up afterwards
• Cantonese-speaking Chinese
• Aged from 18 to 65
• With written consent

You may not qualify if:

• Psychoses
• Previous or current ocular or general acute or chronic disease
• Taking any medication
• Psychoses
• Psychiatric condition warranting hospitalization

Sponsors & Collaborators

• Chinese University of Hong Kong: lead

Study Sites (1)

Department of Psychiatry, Kowloon Hospital, Hong Kong

Hong Kong, China

Location

MeSH Terms

Conditions

Glaucoma; Low Tension Glaucoma

Condition Hierarchy (Ancestors)

Ocular Hypertension; Eye Diseases; Optic Nerve Diseases

Study Officials

• Karina Chan, MBChB, MRCPsych

  Department of Psychiatry, Kowloon Hospital, Hong Kong

  PRINCIPAL INVESTIGATOR

• Dexter Leung, MBChB, FRCS

  Chinese University of Hong Kong

  STUDY DIRECTOR

• Sing Lee, MD, MRCPsych

  Department of Psychiatry, CUHK

  STUDY DIRECTOR

• Dennis Lam, MD, FRCOphth

  Chinese University of Hong Kong

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: May 8, 2006
• First Posted: May 10, 2006
• Study Start: June 1, 2006
• Primary Completion: June 1, 2010
• Study Completion: June 1, 2010
• Last Updated: August 4, 2009

Record last verified: 2009-08

Locations

CN (1)