NCT00319397

Brief Summary

The purpose of this study is to investigate the effects of age, exercise and cardiovascular disease on blood pressure.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
80

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Apr 2004

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2004

Completed
2.1 years until next milestone

First Submitted

Initial submission to the registry

April 26, 2006

Completed
1 day until next milestone

First Posted

Study publicly available on registry

April 27, 2006

Completed
10 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2007

Completed
Last Updated

December 14, 2009

Status Verified

January 1, 2009

First QC Date

April 26, 2006

Last Update Submit

December 10, 2009

Conditions

Cardiovascular DiseaseAging

Keywords

vascular resistancevasomotioncoronary disorderhemodynamicsphysical fitness

Interventions

Exercise-Training ProgramBEHAVIORAL

Eligibility Criteria

Age55 Years - 75 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Sedentary Older Individuals Group:
  • Healthy men and women ages 55-75
  • Normally physically active (performing regular aerobic exercise less than 60 minutes per week) with aerobic capacities below the 80th percentile for age and gender
  • Coronary Artery Disease (CAD) Group:
  • Men and women ages 55-75
  • Written authorization from participant's cardiologist to participate in the study (Note: if Dr. Zervos is the participant's cardiologist, their primary care physician will also be asked to give written authorization)
  • Documented CAD by previous MI or angiography

You may not qualify if:

  • Neurological diseases
  • Diabetes
  • History of migraine headaches
  • Hypertension
  • Glaucoma
  • Pacemaker
  • History of stroke or TIA
  • High cholesterol
  • Current cancer
  • Benign prostatic hyperplasia
  • Allergy to sulfa
  • Carotid disease
  • Currently taking anti-depression, anti-psychotic, or anti-anxiety medications
  • Sedentary Older Individuals Group:
  • Coronary artery or carotid vascular disease
  • +4 more criteria

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Spaulding Rehabilitation Hospital

Boston, Massachusetts, 02114, United States

RECRUITING

Related Publications (7)

  • Hagbarth KE, Vallbo AB. Pulse and respiratory grouping of sympathetic impulses in human muscle-nerves. Acta Physiol Scand. 1968 Sep-Oct;74(1):96-108. doi: 10.1111/j.1748-1716.1968.tb04218.x. No abstract available.

    PMID: 4235387BACKGROUND

  • Wallin BG, Fagius J. Peripheral sympathetic neural activity in conscious humans. Annu Rev Physiol. 1988;50:565-76. doi: 10.1146/annurev.ph.50.030188.003025. No abstract available.

    PMID: 3288106BACKGROUND

  • Eckberg DL, Wallin BG, Fagius J, Lundberg L, Torebjork HE. Prospective study of symptoms after human microneurography. Acta Physiol Scand. 1989 Dec;137(4):567-9. doi: 10.1111/j.1748-1716.1989.tb08804.x. No abstract available.

    PMID: 2690582BACKGROUND

  • Yuasa T, Takata S, Maruyama M, Yasuma K, Yoshizawa H, Kontani M, Nagai H, Sakagami S, Kobayashi K. Low-dose atropine attenuates muscle sympathetic nerve activity in healthy humans. Hypertens Res. 2000 May;23(3):213-8. doi: 10.1291/hypres.23.213.

    PMID: 10821129BACKGROUND

  • Ikuta Y, Shimoda O, Kano T. Quantitative assessment of the autonomic nervous system activities during atropine-induced bradycardia by heart rate spectral analysis. J Auton Nerv Syst. 1995 Mar 18;52(1):71-6. doi: 10.1016/0165-1838(94)00148-d.

    PMID: 7782571BACKGROUND

  • Alcalay M, Izraeli S, Wallach-Kapon R, Tochner Z, Benjamini Y, Akselrod S. Paradoxical pharmacodynamic effect of atropine on parasympathetic control: a study by spectral analysis of heart rate fluctuations. Clin Pharmacol Ther. 1992 Nov;52(5):518-27. doi: 10.1038/clpt.1992.180.

    PMID: 1424426BACKGROUND

  • Smyth HS, Sleight P, Pickering GW. Reflex regulation of arterial pressure during sleep in man. A quantitative method of assessing baroreflex sensitivity. Circ Res. 1969 Jan;24(1):109-21. doi: 10.1161/01.res.24.1.109. No abstract available.

    PMID: 4303309BACKGROUND

MeSH Terms

Conditions

Cardiovascular DiseasesCoronary Artery Disease

Condition Hierarchy (Ancestors)

Coronary DiseaseMyocardial IschemiaHeart DiseasesArteriosclerosisArterial Occlusive DiseasesVascular Diseases

Study Officials

  • J. Andrew Taylor, PhD

    Spaulding Rehabilitation Hospital, Harvard Medical School

    PRINCIPAL INVESTIGATOR

  • Gerasimos Zervos, MD

    Chief of Nuclear Cardiology, Massachusetts General Hospital

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Glen Picard, MA

CONTACT

617-573-2786apicard@partners.org

J. Andrew Taylor, PhD

CONTACT

617-573-2784jandrew_taylor@hms.harvard.edu

Study Design

Study Type
observational
Time Perspective
PROSPECTIVE
Sponsor Type
NIH

Study Record Dates

First Submitted

April 26, 2006

First Posted

April 27, 2006

Study Start

April 1, 2004

Study Completion

March 1, 2007

Last Updated

December 14, 2009

Record last verified: 2009-01

Locations

US(1)