CALERIE (Tufts) - Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy
Dietary Energy Restriction and Metabolic Aging in Humans
2 other identifiers
interventional
44
1 country
1
Brief Summary
This study is one of three CALERIE trials that test the hypothesis that a reduced calorie, nutritionally sound diet increases the length of life and prevents some age-related chronic diseases such as cancer, diabetes, and cardiovascular disease. The three sites that are participating in the CALERIE trial represent a diversity of subject populations and interventional strategies.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for phase_1
Started Mar 2002
Typical duration for phase_1
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2002
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2004
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2004
CompletedFirst Submitted
Initial submission to the registry
December 8, 2004
CompletedFirst Posted
Study publicly available on registry
December 9, 2004
CompletedDecember 11, 2009
February 1, 2006
2.8 years
December 8, 2004
December 9, 2009
Conditions
Keywords
Interventions
Eligibility Criteria
You may qualify if:
- Healthy men and women
- Body mass index (BMI) = 25-30
- Slightly overweight, \< 275 lbs
- Women 25-45, pre-menopause
- Men 25-50
- Not traveling often or planning to move
- Cardiovascular disease or blood pressure greater than 160/90
- Diabetes
- Major psychiatric disorders
- Eating disorders
- Post obese; previous BMI \> 32
- Weight change of more than ten pounds in the past 90 days
- Over 275 pounds
- Smoking
- Regular exercise, more than twice per week
- +8 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
Boston, Massachusetts, 02111-1524, United States
Related Publications (2)
Karl JP, Cheatham RA, Das SK, Hyatt RR, Gilhooly CH, Pittas AG, Lieberman HR, Lerner D, Roberts SB, Saltzman E. Effect of glycemic load on eating behavior self-efficacy during weight loss. Appetite. 2014 Sep;80:204-11. doi: 10.1016/j.appet.2014.05.017. Epub 2014 May 21.
PMID: 24859114DERIVEDRacette SB, Das SK, Bhapkar M, Hadley EC, Roberts SB, Ravussin E, Pieper C, DeLany JP, Kraus WE, Rochon J, Redman LM; CALERIE Study Group. Approaches for quantifying energy intake and %calorie restriction during calorie restriction interventions in humans: the multicenter CALERIE study. Am J Physiol Endocrinol Metab. 2012 Feb 15;302(4):E441-8. doi: 10.1152/ajpendo.00290.2011. Epub 2011 Nov 29.
PMID: 22127229DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Susan B. Roberts, PhD
Jean Mayer USDA HNRCA at Tufts University
Study Design
- Study Type
- interventional
- Phase
- phase 1
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- NIH
Study Record Dates
First Submitted
December 8, 2004
First Posted
December 9, 2004
Study Start
March 1, 2002
Primary Completion
December 1, 2004
Study Completion
December 1, 2004
Last Updated
December 11, 2009
Record last verified: 2006-02