NCT00183066

Brief Summary

The purpose of this study is to collect bone marrow cells for research purposes.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
63

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Jul 2002

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 2002

Completed
3.2 years until next milestone

First Submitted

Initial submission to the registry

September 13, 2005

Completed
3 days until next milestone

First Posted

Study publicly available on registry

September 16, 2005

Completed
6.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2012

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2012

Completed
Last Updated

August 6, 2012

Status Verified

August 1, 2012

Enrollment Period

10.1 years

First QC Date

September 13, 2005

Last Update Submit

August 3, 2012

Conditions

Aging

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Healthy males and females 18 years and older

You may qualify if:

  • Healthy volunteers age 18 and over

You may not qualify if:

  • Significant abnormalities on health history questionnaire or in the results of blood tests
  • Pregnant or nursing mother
  • Participation in another research study within the past six weeks that is felt by the Principal Investigator to be incompatible with this study
  • Severe infection in the past two months
  • Immune disorder, or use of any medication that can alter immune system function
  • A medical or mental health finding showing inability to go through the procedure
  • Body mass index (BMI) greater than 29%
  • Chronic back pain, sciatica, or a compression fracture of the spine
  • Positive test results for viral infections: Hepatitis B, Hepatitis C, or HIV (AIDS)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

NIA Clinical Research Unit located at Harbor Hospital

Baltimore, Maryland, 21225, United States

Location

Related Publications (3)

  • Cashman J, Clark-Lewis I, Eaves A, Eaves C. Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice. Blood. 2002 Feb 1;99(3):792-9. doi: 10.1182/blood.v99.3.792.

    PMID: 11806978BACKGROUND

  • Exley MA, Tahir SM, Cheng O, Shaulov A, Joyce R, Avigan D, Sackstein R, Balk SP. A major fraction of human bone marrow lymphocytes are Th2-like CD1d-reactive T cells that can suppress mixed lymphocyte responses. J Immunol. 2001 Nov 15;167(10):5531-4. doi: 10.4049/jimmunol.167.10.5531.

    PMID: 11698421BACKGROUND

  • Johnson BS, Mueller L, Si J, Collins SJ. The cytokines IL-3 and GM-CSF regulate the transcriptional activity of retinoic acid receptors in different in vitro models of myeloid differentiation. Blood. 2002 Feb 1;99(3):746-53. doi: 10.1182/blood.v99.3.746.

    PMID: 11806973BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

Bone marrow aspirates Whole blood

Study Officials

  • Dan L. Longo, MD

    National Institute on Aging (NIA)

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Time Perspective
PROSPECTIVE
Sponsor Type
NIH
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 13, 2005

First Posted

September 16, 2005

Study Start

July 1, 2002

Primary Completion

August 1, 2012

Study Completion

August 1, 2012

Last Updated

August 6, 2012

Record last verified: 2012-08

Locations

US(1)