Azithromycin Combination Therapy for Malaria

NCT00299208 | Completed Phase 2

• 2 other identifiers: 03-149A0661129
• Study Type: interventional
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this study is to develop a safe, well tolerated, and highly efficacious azithromycin combination treatment for uncomplicated falciparum malaria. Azithromycin is a drug that has shown potential for malaria treatment. It will be combined with other malaria drugs currently approved for treatment in Thailand. About 120 people, ages 20-65, will be enrolled in Thailand. Participants will have severe cases of malaria and they will be hospitalized 28 days for treatment.

Conditions

Plasmodium Falciparum Malaria

Keywords

Malaria

Interventions

Artesunate DRUG

Azithromycin DRUG

Quinine DRUG

Eligibility Criteria

• Age: 20 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Acute symptomatic falciparum malaria infection as determined by malaria smear with a parasite density of 100 to 100,000 asexual parasites/µL with fever, defined as \>37.5ºC, during the current illness, or history (within the last 48 hours) of fever.
• Age: 20-65 years old
• Male or female. All females are required to have a negative human chorionic gonadotropic (hCG) pregnancy test (urine). All females of childbearing potential (not surgically sterile, or less than two years post menopausal) are required to use an acceptable method of contraception, such as implant, injectable, oral contraceptive(s) with additional barrier contraception, intrauterine device, sexual abstinence, or vasectomized partner, throughout the study.
• Written informed consent obtained.
• Willing to stay hospitalized for 28 days for treatment and observations.

You may not qualify if:

• Mixed malaria infection on admission by malaria smear.
• A previous state of intolerance or hypersensitivity to the study drugs quinine, artesunate, or azithromycin or to drugs with similar chemical structures (quinidine, any artemisinin derivative, and macrolides such as erythromycin).
• Malaria drug therapy administered in the past 30 days by history (quinine, chloroquine, mefloquine, artemisinin derivatives, sulfadoxine/pyrimethamine, lumefantrine).
• Previous participation in this trial, or participation in any other studies involving investigational or marketed products, concomitantly or within 30 days prior to entry in the study.
• Clinically significant illness (intercurrent illness e.g. pneumonia, pre-existing condition e..g. malignancy or conditions that may effect absorption of study medication e.g. severe diarrhea or any signs of malnutrition as defined clinically).
• Creatinine \> 1.4 X ULN (\>2.0 mg/dl),
• Glucose \< LLN (75 mg/dl),
• AST, ALT \> 3x ULN (120 U/L), or
• Prolonged QT wave on baseline electrocardiogram (QT \>0.45s)
• Symptoms of severe vomiting (no food or inability to take food during the previous 8 hours).
• Signs or symptoms of severe malaria.
• Anyone who received a transfusion of red blood cells within the prior 30 days.
• Unable and/or unlikely to comprehend and/or follow the protocol.
• Self-reported alcohol and/or any other drug abuse.
• Likelihood of requiring treatment during the study period with drugs not permitted by the study protocol.

Sponsors & Collaborators

• National Institute of Allergy and Infectious Diseases (NIAID): lead

Study Sites (1)

Mahidol University Hospital for Tropical Diseases

Bangkok, 10270, Thailand

Location

MeSH Terms

Conditions

Malaria, Falciparum; Malaria

Interventions

Artesunate; Azithromycin; Quinine

Condition Hierarchy (Ancestors)

Protozoan Infections; Parasitic Diseases; Infections; Mosquito-Borne Diseases; Vector Borne Diseases

Intervention Hierarchy (Ancestors)

Artemisinins; Reactive Oxygen Species; Free Radicals; Inorganic Chemicals; Organic Chemicals; Sesquiterpenes; Terpenes; Hydrocarbons; Erythromycin; Macrolides; Polyketides; Lactones; Cinchona Alkaloids; Alkaloids; Heterocyclic Compounds; Quinuclidines; Heterocyclic Compounds, Bridged-Ring; Quinolines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: NIH

Study Record Dates

• First Submitted: March 3, 2006
• First Posted: March 6, 2006
• Primary Completion: July 1, 2005
• Study Completion: July 1, 2005
• Last Updated: August 27, 2010

Record last verified: 2010-03

Locations

TH (1)