Does Metabolic Syndrome Exist in Anorexia Nervosa?

NCT00271921 | Completed

• 2 other identifiers: R03 DK66033 (completed)R03DK066033
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 2

Brief Summary

The purpose of this study is to examine whether body fat distribution changes that occur with weight gain in women recovering from anorexia nervosa are transient or persistent, and if they are associated with other features of Metabolic Syndrome.

Conditions

Anorexia Nervosa; Metabolic Syndrome

Keywords

eating disorders; anorexia nervosa; body fat distribution; metabolic syndrome; visceral adipose tissue

Interventions

Calorie controlled diet BEHAVIORAL

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• DSM-IV diagnosis of Anorexia Nervosa (except amenorrhea) (restricting or binge eating/purging subtype)
• Female
• Age 18-40
• Medically stable
• Participation in inpatient or daypatient treatment sufficient to restore patient to a BMI of at least 19.5kg/m²

You may not qualify if:

• Additional Major Axis I disorder (including substance abuse or dependence
• On daily prescription medication (including oral contraceptives)
• History of suicide attempt or other self-injurious behavior within the previous 6 months
• Significant current or past medical illness,including diabetes mellitus, heart disease
• Indwelling metallic object (e.g., pacemaker,pump), non-removable metal jewelry or recent metallic ink tattoo

Sponsors & Collaborators

• National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): lead

Study Sites (2)

St. Luke's Roosevelt Hosptial Center

New York, New York, 10025, United States

Location

New York State Psychiatric Institute/Columbia University

New York, New York, 10032, United States

Location

Related Publications (3)

• Schebendach J, Mayer LE, Devlin MJ, Attia E, Walsh BT. Dietary energy density and diet variety as risk factors for relapse in anorexia nervosa: a replication. Int J Eat Disord. 2012 Jan;45(1):79-84. doi: 10.1002/eat.20922. Epub 2011 Mar 29.

  PMID: 21448937 DERIVED

• Bodell LP, Mayer LE. Percent body fat is a risk factor for relapse in anorexia nervosa: a replication study. Int J Eat Disord. 2011 Mar;44(2):118-23. doi: 10.1002/eat.20801.

  PMID: 20127939 DERIVED

• Mayer LE, Klein DA, Black E, Attia E, Shen W, Mao X, Shungu DC, Punyanita M, Gallagher D, Wang J, Heymsfield SB, Hirsch J, Ginsberg HN, Walsh BT. Adipose tissue distribution after weight restoration and weight maintenance in women with anorexia nervosa. Am J Clin Nutr. 2009 Nov;90(5):1132-7. doi: 10.3945/ajcn.2009.27820. Epub 2009 Sep 30.

  PMID: 19793856 DERIVED

MeSH Terms

Conditions

Anorexia Nervosa; Metabolic Syndrome; Feeding and Eating Disorders

Interventions

Caloric Restriction

Condition Hierarchy (Ancestors)

Mental Disorders; Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Signs and Symptoms, Digestive; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Diet Therapy; Nutrition Therapy; Therapeutics; Energy Intake; Diet; Nutritional Physiological Phenomena; Diet, Food, and Nutrition; Physiological Phenomena

Study Officials

• Laurel Mayer, MD

  New York State Psychiatric Institute/Columbia University

  PRINCIPAL INVESTIGATOR

• Henry Ginsberg, MD

  Columbia University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH

Study Record Dates

• First Submitted: December 29, 2005
• First Posted: January 4, 2006
• Study Start: September 1, 2005
• Primary Completion: June 1, 2007
• Study Completion: June 1, 2007
• Last Updated: December 18, 2012

Record last verified: 2012-12

Locations

US (2)