Energy Homeostasis in Anorexia Nervosa
1 other identifier
observational
120
1 country
1
Brief Summary
The purpose of this study is to investigate the potential biological predispositions that contribute to the difficulty patients with anorexia nervosa have in maintaining normal weight.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Apr 2000
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2000
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2004
CompletedFirst Submitted
Initial submission to the registry
August 24, 2006
CompletedFirst Posted
Study publicly available on registry
August 25, 2006
CompletedJanuary 13, 2010
January 1, 2010
August 24, 2006
January 12, 2010
Conditions
Keywords
Eligibility Criteria
You may qualify if:
- DSM-IV diagnosis of Anorexia Nervosa
- BMI ≤ 17.5kg/m2 (equivalent to 80% of ideal body weight)
- Medically stable
- Participation in in-patient treatment sufficient to restore patient to a BMI of at least 19kg/m2
You may not qualify if:
- On medication\*
- Current substance abuse or dependence
- History of suicide attempt or other self-injurious behavior within the previous 6 months
- Non-removable metal on/in their body (e.g. metal pacemaker, surgical clips, metallic-ink tattoos)
- Controls:
- No current psychiatric disorder (including eating disorder, depression, bipolar disorder, schizophrenia, substance abuse/dependence)
- No history of an eating disorder
- BMI greater than 19kg/m2 and less than 21kg/m2
- Weight stable (+/- 2kg) for the previous 6 months
- No history of excessive or repeated dieting
- No history of excessive exercise (defined as greater than 6 hours/week)
- Regular menstrual cycles
- On medication\*
- Pregnant or lactating
- Significant medical problem
- +2 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
New York State Psychiatric Institute, Unit 98
New York, New York, 10032, United States
Related Publications (4)
Mayer L, Walsh BT, Pierson RN Jr, Heymsfield SB, Gallagher D, Wang J, Parides MK, Leibel RL, Warren MP, Killory E, Glasofer D. Body fat redistribution after weight gain in women with anorexia nervosa. Am J Clin Nutr. 2005 Jun;81(6):1286-91. doi: 10.1093/ajcn/81.6.1286.
PMID: 15941877RESULTSchebendach J, Mayer LE, Devlin MJ, Attia E, Walsh BT. Dietary energy density and diet variety as risk factors for relapse in anorexia nervosa: a replication. Int J Eat Disord. 2012 Jan;45(1):79-84. doi: 10.1002/eat.20922. Epub 2011 Mar 29.
PMID: 21448937DERIVEDBodell LP, Mayer LE. Percent body fat is a risk factor for relapse in anorexia nervosa: a replication study. Int J Eat Disord. 2011 Mar;44(2):118-23. doi: 10.1002/eat.20801.
PMID: 20127939DERIVEDMayer LE, Klein DA, Black E, Attia E, Shen W, Mao X, Shungu DC, Punyanita M, Gallagher D, Wang J, Heymsfield SB, Hirsch J, Ginsberg HN, Walsh BT. Adipose tissue distribution after weight restoration and weight maintenance in women with anorexia nervosa. Am J Clin Nutr. 2009 Nov;90(5):1132-7. doi: 10.3945/ajcn.2009.27820. Epub 2009 Sep 30.
PMID: 19793856DERIVED
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Laurel Mayer, MD
New York State Psychiatric Institute
Study Design
- Study Type
- observational
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- NIH
Study Record Dates
First Submitted
August 24, 2006
First Posted
August 25, 2006
Study Start
April 1, 2000
Study Completion
December 1, 2004
Last Updated
January 13, 2010
Record last verified: 2010-01