Effectiveness of Cognitive Remediation Therapy in Improving Treatment Retention in People With Anorexia Nervosa
Cognitive Remediation Therapy for Anorexia Nervosa
3 other identifiers
interventional
46
1 country
1
Brief Summary
This study will evaluate the effectiveness of adding cognitive remediation therapy to cognitive behavioral therapy for treating people with anorexia nervosa.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for phase_1
Started Jan 2008
Longer than P75 for phase_1
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2008
CompletedFirst Submitted
Initial submission to the registry
January 4, 2008
CompletedFirst Posted
Study publicly available on registry
January 28, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2011
CompletedApril 10, 2012
April 1, 2012
3.9 years
January 4, 2008
April 9, 2012
Conditions
Outcome Measures
Primary Outcomes (1)
Length of time to discontinue treatment (attrition rate)
Measured at Month 6
Secondary Outcomes (1)
Changes in general cognitive processes and those related to anorexia nervosa
Measured at Month 6
Study Arms (2)
1
EXPERIMENTALGroup receiving cognitive behavioral therapy for anorexia nervosa (CBT-AN)
2
EXPERIMENTALGroup receiving cognitive behavioral therapy for anorexia nervosa, plus cognitive remediation therapy (CBT-AN+CRT)
Interventions
CRT includes eight sessions over 6 months that aim to improve cognitive flexibility and strengthen thinking skills.
CBT includes 20 to 28 weekly psychotherapy sessions over 6 months, depending on treatment group assignment. CBT sessions aim to change participants' beliefs and behaviors toward eating disorders and to teach ways to handle the daily struggles of an eating disorder.
Eligibility Criteria
You may qualify if:
- Meets diagnostic criteria for AN
- Medically stable for outpatient treatment. More information on this can be found in the protocol.
- English literacy
You may not qualify if:
- Current psychotic illness
- History of significant brain injury
- Current dependence on drugs or alcohol
- Physical conditions (e.g., diabetes mellitus, pregnancy) known to influence eating or weight
- Previously received CBT or CRT for AN (using the same treatment models as in the study)
- Ideal body weight of less than 75%
- Taking psychotropic medications (antidepressants and antipsychotics) unless on a stable dose for 2 months prior to study entry
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Stanford Universitylead
- National Institute of Mental Health (NIMH)collaborator
Study Sites (1)
Stanford University
Stanford, California, 94305, United States
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
James D. Lock, MD, PhD
Stanford University
Study Design
- Study Type
- interventional
- Phase
- phase 1
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 4, 2008
First Posted
January 28, 2008
Study Start
January 1, 2008
Primary Completion
December 1, 2011
Study Completion
December 1, 2011
Last Updated
April 10, 2012
Record last verified: 2012-04