Observation of Young Patients Who Are Undergoing Surgery for Craniopharyngioma
Prospective, Multi-Center Survey Study of Children and Adolescents With Craniopharyngioma
3 other identifiers
interventional
120
4 countries
109
Brief Summary
RATIONALE: Collecting information on how craniopharyngioma is diagnosed and treated may help doctors predict a patient's response to treatment and help plan the best treatment. It may also help identify the intermediate- and long-term effects of treatment. PURPOSE: This clinical trial is collecting information on diagnosis, treatment, and quality of life of young patients who are undergoing surgery for craniopharyngioma.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started May 2001
Longer than P75 for not_applicable
109 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2001
CompletedFirst Submitted
Initial submission to the registry
November 22, 2005
CompletedFirst Posted
Study publicly available on registry
November 24, 2005
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2007
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2009
CompletedAugust 2, 2013
October 1, 2007
6.3 years
November 22, 2005
August 1, 2013
Conditions
Keywords
Interventions
Eligibility Criteria
Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.
Sponsors & Collaborators
Study Sites (109)
Krankenhaus Dornbirn
Dornbirn, A-6850, Austria
Landeskrankenhaus Feldkirch
Feldkirch-Tisis, A-6807, Austria
Universitaet Kinderklinik
Graz, 8036, Austria
Innsbruck Universitaetsklinik
Innsbruck, A-6020, Austria
Landeskrankenhaus Klagenfurt
Klagenfurt, 9026, Austria
LKH Leoben
Leoben, A-8700, Austria
A. oe. Krankenhaus der Barmherzigen Schwestern Kinderabteilung
Linz, 4010, Austria
Landes-Kinderkrankenhaus
Linz, A-4020, Austria
St. Johanns-Spital
Salzburg, A-5020, Austria
Kardinal Schwarzenbersches Krankenhaus Betriebsgesellschraft mbH Kinderspital
Schwarzach, 5620, Austria
A. oe. Landeskrankenhaus Abt. fuer Kinderkrankheiten
Steyr, 4400, Austria
Allg. Krankenhaus der Stadt Wien Universitaets-Kinderklinik
Vienna, 1090, Austria
St. Anna Children's Hospital
Vienna, A-1090, Austria
Kinderklinik - Universitaetsklinikum Aachen
Aachen, D-52074, Germany
Klinikum Augsburg
Augsburg, D-86156, Germany
Caritas-Krankenhaus Bad Mergentheim
Bad Mergentheim, D-97980, Germany
Klinikum am Bamberg
Bamberg, 96049, Germany
Klinikum Bayreuth
Bayreuth, D-95445, Germany
Helios Klinikum Berlin
Berlin, 13125, Germany
Charite - Campus Charite Mitte
Berlin, D-10117, Germany
Charite University Hospital - Campus Virchow Klinikum
Berlin, D-13353, Germany
Evangelisches Krankenhauus Bielfeld
Biefeld, 33617, Germany
Kinderklinik der Universitaet Bonn
Bonn, D-53113, Germany
Klinikum Bremen-Mitte
Bremen, D-28205, Germany
Allgemeinen Krankenhaus Celle Kinderklinik
Celle, 29223, Germany
Klinikum Chemnitz gGmbH
Chemnitz, D-09116, Germany
Klinikum Coburg
Coburg, 96450, Germany
Kliniken der Stadt Koeln gGmbH - Kinderkrankenhaus Riehl
Cologne, D-50735, Germany
Children's Hospital
Cologne, D-50924, Germany
Carl - Thiem - Klinkum Cottbus
Cottbus, D-03048, Germany
Vestische Kinderklinik Universitaetsklinik Witten/Herdecke
Datteln, 45711, Germany
Klinikum Lippe - Detmold
Detmold, D-32756, Germany
Staedtisches Krankenhaus Dresden - Neustadt
Dresden, D-01129, Germany
Universitatsklinikum Carl Gustav Carus
Dresden, D-01307, Germany
Klinikum Duisburg
Duisburg, D-47055, Germany
Klinikum Erfurt
Erfurt, 99089, Germany
Universitaets - Kinderklinik
Erlangen, D-91054, Germany
Klinikum der J.W. Goethe Universitaet
Frankfurt, D-60590, Germany
Universitaetskinderklinik - Universitaetsklinikum Freiburg
Freiburg im Breisgau, D-79106, Germany
Kinderklinik
Giessen, D-35385, Germany
Universitaetsklinikum Goettingen
Göttingen, D-37075, Germany
Universitats - Kinderklinik
Greiswald, 17487, Germany
Kreiskrankenhaus Gummersbach GMBH
Gummersbach, D-51643, Germany
Universitaetsklinikum Halle
Halle, D-06097, Germany
University Medical Center Hamburg - Eppendorf
Hamburg, D-20246, Germany
Medizinische Hochschule Hannover
Hanover, D-30625, Germany
Kreskrankenhaus Kinderabteilung
Heide, 25746, Germany
Universitaets-Kinderklinik Heidelberg
Heidelberg, D-69120, Germany
SLK - Kliniken Heilbronn GmbH - Klinikum am Gesundbrunnen
Heilbronn, D-74064, Germany
Gemeinschaftskrankenhaus
Herdecke, 58313, Germany
Staedtisches Krankenhaus Hildesheim
Hildesheim, D-31134, Germany
Universitaetsklinikum des Saarlandes
Homburg, 66421, Germany
Clinic for Bone Marrow Transplantation and Hematology and Oncology
Idar-Oberstein, D-55743, Germany
Universitaets - Kinderklinik
Jena, D-07745, Germany
Municipal Hospital Complex of the University
Kaiserslautern, 67655, Germany
Staedtisches Klinikum Karlsruhe gGmbH
Karlsruhe, 76133, Germany
Klinikum Kassel
Kassel, D-34125, Germany
Staedtisches Krankenhaus Kiel
Kiel, 23116, Germany
University Hospital Schleswig-Holstein - Kiel Campus
Kiel, D-24105, Germany
Klinikum Kemperhof Koblenz
Koblenz, D-56065, Germany
Klinik Konstanz
Konstanz, 78461, Germany
Klinikum Krefeld GmbH
Krefeld, D-47805, Germany
Kinderkrankenhaus St. Marien
Landshut, 84036, Germany
Universitaets - Kinderklinik
Leipzig, D-04317, Germany
St. Annastift Krankenhaus
Ludwigshafen, 67065, Germany
Universitaets - Kinderklinik - Luebeck
Lübeck, D-23538, Germany
Universitatsklinikum der MA
Magdeburg, 39112, Germany
Johannes Gutenberg University
Mainz, D-55131, Germany
Staedtisches Klinik - Kinderklinik
Mannheim, D-68167, Germany
Universitaets - Kinderklinik
Marburg, 35033, Germany
Klinikum Minden
Minden, D-32423, Germany
Krankenhaus Neuwerk Klinik fuer Kinder und Jugendmedizin
Mönchengladbach, D-41066, Germany
Krankenhaus Muenchen Schwabing
Munich, 80804, Germany
Dr. von Haunersches Kinderspital der Universitaet Muenchen
Munich, D-80337, Germany
Staedtisches Krankenhaus Muenchen - Harlaching
Munich, D-81545, Germany
Klinik und Poliklinik fuer Kinder und Jugendmedizin - Universitaetsklinikum Muenster
Münster, D-48149, Germany
Klinikum Neubrandenburg
Neubrandenburg, 17036, Germany
Lukaskrankenhaus Neuss
Neuss, D-41464, Germany
Marienhaus Klinikum St. Elisabeth Neuwied
Neuwied, 56564, Germany
Cnopf'sche Kinderklinik
Nuremberg, 90419, Germany
Klinikum Nuernberg - Klinikum Sued
Nuremberg, D-90471, Germany
Klinikum Oldenburg
Oldenburg, 26133, Germany
Marien Hospital
Osnabrück, D-49074, Germany
Paracelsus - Klinik Osnabrueck
Osnabrück, D-49076, Germany
Klinik St. Hedwig-Kinderklinik
Regensburg, 93049, Germany
Kinderklinik - Universitaetsklinikum Rostock
Rostock, D-18057, Germany
Saarbrucker Winterbergkliniken
Saarbrücken, 66119, Germany
Johanniter-Kinderklinik
Sankt Augustin, 53757, Germany
Klinikum Schwerin
Schwerin, D-19049, Germany
Kinderklink Siegen Deutsches Rotes Kreuz
Siegen, D-57072, Germany
Olgahospital
Stuttgart, D-70176, Germany
Krankenanstalt Mutterhaus der Borromaerinnen
Trier, D-54290, Germany
Universitaetsklinikum Tuebingen
Tübingen, D-72076, Germany
Comprehensive Cancer Center Ulm at Universitaetsklinikum Ulm
Ulm, D-89075, Germany
St. Marienhospital - Vechta
Vechta, D-49377, Germany
Staedtisches Klinikum - Howedestrase
Vechta, D-49377, Germany
Dr. Horst-Schmidt-Kliniken
Wiesbaden, D-65199, Germany
Reinhard-Nieter-Krankenhaus
Wilhelmshaven, D-26389, Germany
Klinikum der Stadt Wolfsburg
Wolfsburg, D-38440, Germany
Helios Kliniken Wuppertal University Hospital
Wuppertal, D-42283, Germany
Universitaets - Kinderklinik Wuerzburg
Würzburg, D-97080, Germany
Lanssjukhuset Ryhov
Jönköping, S-55185, Sweden
Kantonspital Aarau
Aarau, CH-5001, Switzerland
Universitaets-Kinderspital beider Basel
Basel, CH-4005, Switzerland
Ospedale "la Carita", Locarno
Locarno, 6600, Switzerland
Kinderspital Luzern
Lucerne, CH-6000, Switzerland
Ostschweizer Kinderspital
Sankt Gallen, 9006, Switzerland
Kantonsspital Winterthur
Winterthur, CH-8400, Switzerland
University Children's Hospital
Zurich, CH-8032, Switzerland
Related Publications (12)
Roth CL, Gebhardt U, Muller HL. Appetite-regulating hormone changes in patients with craniopharyngioma. Obesity (Silver Spring). 2011 Jan;19(1):36-42. doi: 10.1038/oby.2010.80. Epub 2010 Apr 8.
PMID: 20379145RESULTMuller HL, Gebhardt U, Schroder S, Pohl F, Kortmann RD, Faldum A, Zwiener I, Warmuth-Metz M, Pietsch T, Calaminus G, Kolb R, Wiegand C, Sorensen N; study committee of KRANIOPHARYNGEOM 2000/2007. Analyses of treatment variables for patients with childhood craniopharyngioma--results of the multicenter prospective trial KRANIOPHARYNGEOM 2000 after three years of follow-up. Horm Res Paediatr. 2010;73(3):175-80. doi: 10.1159/000284358. Epub 2010 Mar 3.
PMID: 20197669RESULTSowithayasakul P, Beckhaus J, Ozyurt J, Bison B, Friedrich C, Muller HL. Prolactin serum concentrations in childhood-onset craniopharyngioma patients. J Endocrinol Invest. 2025 Sep;48(9):2041-2051. doi: 10.1007/s40618-025-02622-4. Epub 2025 Jun 7.
PMID: 40481916DERIVEDMann-Markutzyk LV, Beckhaus J, Ozyurt J, Mehren A, Friedrich C, Muller HL. Daytime sleepiness and health-related quality of life in patients with childhood-onset craniopharyngioma. Sci Rep. 2025 Mar 19;15(1):9407. doi: 10.1038/s41598-025-94384-5.
PMID: 40108339DERIVEDWagener K, Beckhaus J, Boekhoff S, Friedrich C, Muller HL. Sporadic and neurofibromatosis type 2-associated meningioma in children and adolescents. J Neurooncol. 2023 Jul;163(3):555-563. doi: 10.1007/s11060-023-04344-0. Epub 2023 Jul 4.
PMID: 37402092DERIVEDBeckhaus J, Friedrich C, Boekhoff S, Calaminus G, Bison B, Eveslage M, Timmermann B, Flitsch J, Muller HL. Outcome after pediatric craniopharyngioma: the role of age at diagnosis and hypothalamic damage. Eur J Endocrinol. 2023 Mar 2;188(3):lvad027. doi: 10.1093/ejendo/lvad027.
PMID: 36857103DERIVEDMehren A, Ozyurt J, Zu Klampen P, Boekhoff S, Thiel CM, Muller HL. Self- and informant-rated apathy in patients with childhood-onset craniopharyngioma. J Neurooncol. 2018 Oct;140(1):27-35. doi: 10.1007/s11060-018-2936-z. Epub 2018 Jul 3.
PMID: 29971569DERIVEDOzyurt J, Muller HL, Warmuth-Metz M, Thiel CM. Hypothalamic tumors impact gray and white matter volumes in fronto-limbic brain areas. Cortex. 2017 Apr;89:98-110. doi: 10.1016/j.cortex.2017.01.017. Epub 2017 Feb 3.
PMID: 28259055DERIVEDDaubenbuchel AM, Hoffmann A, Eveslage M, Ozyurt J, Lohle K, Reichel J, Thiel CM, Martens H, Geenen V, Muller HL. Oxytocin in survivors of childhood-onset craniopharyngioma. Endocrine. 2016 Nov;54(2):524-531. doi: 10.1007/s12020-016-1084-5. Epub 2016 Sep 1.
PMID: 27585663DERIVEDHoffmann A, Warmuth-Metz M, Lohle K, Reichel J, Daubenbuchel AM, Sterkenburg AS, Muller HL. Fusiform dilatation of the internal carotid artery in childhood-onset craniopharyngioma: multicenter study on incidence and long-term outcome. Pituitary. 2016 Aug;19(4):422-8. doi: 10.1007/s11102-016-0722-5.
PMID: 27125511DERIVEDOzyurt J, Thiel CM, Lorenzen A, Gebhardt U, Calaminus G, Warmuth-Metz M, Muller HL. Neuropsychological outcome in patients with childhood craniopharyngioma and hypothalamic involvement. J Pediatr. 2014 Apr;164(4):876-881.e4. doi: 10.1016/j.jpeds.2013.12.010. Epub 2014 Feb 6.
PMID: 24507865DERIVEDRoth CL, Enriori PJ, Gebhardt U, Hinney A, Muller HL, Hebebrand J, Reinehr T, Cowley MA. Changes of peripheral alpha-melanocyte-stimulating hormone in childhood obesity. Metabolism. 2010 Feb;59(2):186-94. doi: 10.1016/j.metabol.2009.06.031. Epub 2009 Sep 18.
PMID: 19766264DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Hermann Mueller, MD
Klinikum Oldenburg
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
November 22, 2005
First Posted
November 24, 2005
Study Start
May 1, 2001
Primary Completion
September 1, 2007
Study Completion
September 1, 2009
Last Updated
August 2, 2013
Record last verified: 2007-10