The Genetic Basis of Inherited Neurologic Deficits in People With Schizophrenia

NCT00247637 | Completed

• 7 other identifiers: R01MH065571R01MH065707R01MH065578R01MH065588R01MH065554R01MH065562DNBBS 7G-GRR
• Study Type: observational
• Target: 2,025
• Locations: 1 country
• Sites: 7

Brief Summary

This is a study of the genetic basis of brain dysfunction in people with schizophrenia.

Conditions

Schizophrenia

Keywords

Mental Health; Psychosis; Genetics; Heredity

Outcome Measures

Primary Outcomes (1)

• percent inhibition to the 60 msec prepulse, P50 suppression, proportion of correct saccades, d, number correct in the reorder condition, the total recall score

  The primary outcome measure for each endophenotype is as follows: for prepulse inhibition (PPI) the primary measure is the percent inhibition to the 60 msec prepulse; for P50 suppression it is the difference in amplitude between the test and conditioning stimuli; for antisaccade it is the proportion of correct saccades; for the DS-CPT it is (d') which is based on correct target detections and incorrect responses to nontargets; for LNS it is the number correct in the reorder condition; for CVLT it is the total recall score summed across 5 trials.

  Upon entry to the study

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The subject population will include schizophrenia probands (12 per site per year), first degree relatives (36 per site per year) and normal comparison subjects (15 per site per year). The proband must meet the diagnosis of schizophrenia by DSM-IV criteria. There must be at least one parent and one unaffected sibling in the pedigree. Therefore a total of 315 subjects will be enrolled at each site each year with a total of 2205 enrolled across all 7 sites. Schizophrenia probands and normal subjects will be between 18 and 65 years of age. Exclusion criteria include visual or hearing impairments, history of head trauma, organic brain dysfunction, neurological disease, and significant drug or alcohol use and for controls, significant psychiatric history and/or current use of psychotropic medications. We will include equal numbers of men and women and all appropriate subjects willing to participate regardless of ethnic background.

You may qualify if:

• Families with at least one member who has schizophrenia

You may not qualify if:

• N/A

Sponsors & Collaborators

• University of California, San Diego: lead
• National Institute of Mental Health (NIMH): collaborator

Study Sites (7)

University of California Los Angeles

Los Angeles, California, 90073, United States

Location

University of California, San Diego

San Diego, California, 92103, United States

Location

University of Colorado Health Sciences Center

Denver, Colorado, 80220, United States

Location

Harvard University

Boston, Massachusetts, 02115, United States

Location

Mount Sinai School of Medicine

New York, New York, 10029, United States

Location

University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

Location

University of Washington and VA Puget Sound Health Care System

Seattle, Washington, 98108, United States

Location

Related Links

• Click here for more information on the Schizophrenia Research Program

Biospecimen

Retention: SAMPLES WITH DNA

Whole blood was sent to the Cell Repository at Rutgers toestablish cell lines.

MeSH Terms

Conditions

Schizophrenia; Psychological Well-Being; Psychotic Disorders

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders; Personal Satisfaction; Behavior

Study Officials

• David Braff, MD

  University of California, San Diego

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: FAMILY BASED
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: October 31, 2005
• First Posted: November 2, 2005
• Study Start: May 1, 2003
• Primary Completion: September 1, 2008
• Study Completion: September 1, 2008
• Last Updated: July 3, 2013

Record last verified: 2013-07

Locations

US (7)