Genetic Research in Schizophrenia Using DNA Markers and Clinical Phenotypes

NCT00108303 | Completed Results

• 1 other identifier: ADRD-007-03S
• Study Type: observational
• Target: 538
• Locations: 1 country
• Sites: 1

Brief Summary

Schizophrenia has long been known to be an illness with significant evidence for a genetic predisposition. The purpose of this study is to determine the genetic abnormalities that cause childhood and adult onset schizophrenia.

Conditions

Schizophrenia

Keywords

schizophrenia

Outcome Measures

Primary Outcomes (3)

• Genetic Linkage

  Log of the Odds for Linkage, a standard genetic analysis metric. The number shown as a result is from a polymorphism in the promoter of the gene for the alpha7 nicotinic receptor on chromosome. Its presence in the individuals in this study, considering all three groups in one analysis, is compared to what of P50 sensory gating. P50 is a Positive wave in scalp-recorded auditory evoked potential that occurs 50 msec after the sound stimulus. P50 sensory gating is the decrement in this wave to the second of repeated sounds. The log of the odds is the common logarithm of the ratio of the odds that the gene polymorphism and P50 sensory gating are associated versus the odds that they are both distributed in the individuals at random. It is similar to the more common chi squared.

  ten years

• Heritability Coefficient

  h squared which ranges from 0 to 1. This number is similar to the more standard Pearson's correlation coefficient, except that the variable, in this case P50 sensory gating, is correlated across the statuses: schizophrenia proband (has the illness), schizophrenia relative (not ill but relative of someone who is), or control (not ill and has no known ill relative, P50 is a Positive wave in scalp-recorded auditory evoked potential that occurs 50 msec after the sound stimulus. P50 sensory gating is the decrement in this wave to the second of repeated sounds.

  5 years

• Log of the ODDS of Linkage

  Log of the ODDS ratio of Linkage divided by the ODDS of no linkage from a maximum likelihood analysis conducted using the statistical program LINKAGE

  1 day

Study Arms (1)

Diagnostic

A diagnostic was performed

Other: Diagnostic

Interventions

Diagnostic OTHER

Diagnostic evaluation for schizophrenia. Schizophrenia includes schizophrenia and schizoaffective disorder.

Diagnostic

Eligibility Criteria

• Age: 1 Year - 79 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Persons with schizophrenia, their relatives, and controls

You may qualify if:

• Individuals thought to have schizophrenia or schizoaffective disorder, be the parent of such an individual, or be in the matched control group of unrelated individuals not thought to have schizophrenia or schizoaffective disorder

You may not qualify if:

• Unable to give informed consent;
• Psychotic disorder judged to be secondary to substance abuse, psychotic disorder that appears to be secondary to a known medical or neurological disorder, or severe mental retardation

Sponsors & Collaborators

• VA Office of Research and Development: lead

Study Sites (1)

VA Eastern Colorado Health Care System, Denver

Denver, Colorado, 80220, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

dna

MeSH Terms

Conditions

Schizophrenia

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders

Limitations and Caveats

Genetic linkage and association do not replicate well across studies. This study should be viewed in this context.

Results Point of Contact

• Title: Dr. Robert Freedman
• Organization: VA

Robert.Freedman@ucdenver.edu

3037244940

Study Officials

• Robert Freedman, MD

  VA Eastern Colorado Health Care System, Denver

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: observational
• Observational Model: FAMILY BASED
• Time Perspective: PROSPECTIVE
• Sponsor Type: FED
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 14, 2005
• First Posted: April 15, 2005
• Study Start: January 1, 2004
• Primary Completion: December 1, 2008
• Study Completion: December 1, 2008
• Last Updated: January 7, 2016
• Results First Posted: January 7, 2016

Record last verified: 2015-12

Locations

US (1)