NCT00184899|Completed
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Sponsor study identifier
Secondary identifiers
interventional
20
1 country
1
Study Start
August 2005
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
August 2006
Date type not reportedThis date has not been verified as actual or estimated.
The metabolic syndrome is associated with hyperdynamic circulation and sympathetic activation. Recently, Bakker et al. (Atherosclerosis 2002) described the hypothesis that free fatty acids are responsible for this association. The investigators hypothesize that in patients with obesity and the metabolic syndrome, an increased intracellular concentration of long-chain fatty acyl (LCFA)-CoA (the intracellular equivalent of free fatty acids) induces an increase in adenosine. Adenosine receptor stimulation, in turn, induces vasodilation and sympathetic activation. The investigators aimed to assess this effect of free fatty acids on the adenosine system in healthy volunteers.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 2006
Date type not reportedThis date has not been verified as actual or estimated.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
August 2005
Date type not reportedThis date has not been verified as actual or estimated.
September 12, 2005
Actual (reported)September 16, 2005
Actual (reported)August 2006
Date type not reportedThis date has not been verified as actual or estimated.
Forearm blood flow
Vasoactive effect of caffeine
Sympathetic activity (noradrenaline spillover, spectral analysis)
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Radboud University Nijmegen Medical Centre
Nijmegen, 6500HB, Netherlands
Bakker SJ, Gans RO, ter Maaten JC, Teerlink T, Westerhoff HV, Heine RJ. The potential role of adenosine in the pathophysiology of the insulin resistance syndrome. Atherosclerosis. 2001 Apr;155(2):283-90. doi: 10.1016/s0021-9150(00)00745-0.
Paul Smits, MD, PhD
Radboud University Medical Center
First Submitted
September 12, 2005
First Posted
September 16, 2005
Study Start
August 2005
Date type not reportedThis date has not been verified as actual or estimated.
Study Completion
August 2006
Date type not reportedContact the study team to confirm eligibility.
This date has not been verified as actual or estimated.
Last Updated
March 1, 2007
Record last verified: 2007-02
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Source: ClinicalTrials.gov.
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