NCT01008878

Brief Summary

This study is a randomized, controlled and opened trial designed to compare the effects of an interdisciplinary moderate-intensity lifestyle modification program vs. conventional treatment by primary care physicians. We want to show the benefits of coherent interdisciplinary care in the obesity clinic of CHUS (Centre Hospitalier Universitaire de Sherbrooke) in comparison to the conventional treatment in order to:

  • Improve subjects' characteristic features of metabolic syndrome: weight, waist circumference, fatty mass, plasma lipid profile, blood pressure, fasting glycaemia, and HbA1c;
  • Improve our patients' nutritive practices;
  • Decrease our patients' sedentary lifestyle;
  • Improve our patients' motivation to lose weight, and to improve their quality of life; We also wish to define predictors of answer in order to better select the patients if necessary, and evaluate the costs incurred by the health system.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60

participants targeted

Target at P25-P50 for not_applicable obesity

Timeline
Completed

Started Mar 2004

Typical duration for not_applicable obesity

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2004

Completed
2.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2006

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2006

Completed
3.4 years until next milestone

First Submitted

Initial submission to the registry

November 5, 2009

Completed
1 day until next milestone

First Posted

Study publicly available on registry

November 6, 2009

Completed
Last Updated

November 6, 2009

Status Verified

November 1, 2009

Enrollment Period

2.3 years

First QC Date

November 5, 2009

Last Update Submit

November 5, 2009

Conditions

Outcome Measures

Primary Outcomes (1)

  • After 6 months of follow-up, the treatment group proportion achieved a 5% reduction in body weight compared to the control group.

    6 months

Secondary Outcomes (2)

  • Weight; fatty mass; features of the metabolic syndrome; food intake; energy expenditure; quality of life; motivation; cost/effectiveness.

  • Metabolic syndrome characteristics

    18 months

Interventions

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • referred to the obesity clinic by a medical doctor;
  • BMI \> 27 kg/m²; (Body Mass Index)
  • metabolic associated syndrome according to the definition of the NCEP-ATP III
  • be able to give an inform consent

You may not qualify if:

  • Impossibility to be present at the visits
  • Physical/motor incapacity (or other) making one unable and insecure to walk at a moderate to rapid speed for 6 min and more
  • Use of an anti-obesity treatment the last 3 months
  • Bariatric Surgery in the past
  • Planned Pregnancy
  • Pacemaker

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Centre de Recherche Clinique (CRC), Centre Hospitalier Universitaire de Sherbrooke

Sherbrooke, Quebec, J1H 5N4, Canada

Location

MeSH Terms

Conditions

ObesityMetabolic Syndrome

Condition Hierarchy (Ancestors)

OverweightOvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and SymptomsInsulin ResistanceHyperinsulinismGlucose Metabolism DisordersMetabolic Diseases

Study Officials

  • Marie-France Langlois, MD

    Medecine Department, Division of endocrinology, CHUS

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER

Study Record Dates

First Submitted

November 5, 2009

First Posted

November 6, 2009

Study Start

March 1, 2004

Primary Completion

June 1, 2006

Study Completion

June 1, 2006

Last Updated

November 6, 2009

Record last verified: 2009-11

Locations