Exercise,Metabolic Syndrome and Weight Regain (Echocardiography Substudy)
Exercise in Patients With Metabolic Syndrome and Weight Regain - Echocardiography Substudy
2 other identifiers
interventional
36
0 countries
N/A
Brief Summary
We plan to test the hypothesis that patients with metabolic syndrome will have impaired left ventricular diastolic parameters. These parameters will be measured before and after a stress test at the end of a 3 month period of exercise training and a 10% weight loss.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Oct 2007
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2007
CompletedFirst Submitted
Initial submission to the registry
October 11, 2007
CompletedFirst Posted
Study publicly available on registry
October 15, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2008
CompletedStudy Completion
Last participant's last visit for all outcomes
October 1, 2008
CompletedResults Posted
Study results publicly available
November 22, 2016
CompletedMarch 1, 2017
November 1, 2016
1 year
October 11, 2007
January 11, 2010
January 17, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Mean Resting E/E'
E/E' is an echocardiographic parameter where E = early mitral inflow velocity and E' = early diastolic mitral annular motion. Measured in all participants prior to treadmill stress test.
12 weeks
Post-exercise E/E'
E/E' is an echocardiographic parameter where E = early mitral inflow velocity and E' = early diastolic mitral annular motion. Measured in all participants immediately following treadmill stress test.
12 weeks
Secondary Outcomes (2)
Mean Resting Maximal Oxygen Uptake (VO2 Max)
12 weeks
Change in Maximal Oxygen Uptake (VO2 Max)
12 weeks
Study Arms (1)
Stress Echocardiography
EXPERIMENTALEchocardiography was performed prior to and within 60 seconds of completing the standard Bruce treadmill protocol.
Interventions
Echocardiography was performs prior to and within 60 seconds of completing the standard Bruce treadmill protocol.
Eligibility Criteria
You may qualify if:
- of 5 criteria for metabolic syndrome
- Ability to exercise for 45 min 5 days a week
You may not qualify if:
- No diabetes
- Established coronary disease
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (1)
Chockalingam A, Linden MA, Dellsperger KC, Thomas TR. Correlation of Normal Diastolic Cardiac Function With VO in the Metabolic Syndrome. Prev Cardiol. 2009 Summer;12(3):163-8. doi: 10.1111/j.1751-7141.2009.00027.x.
PMID: 19523060RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Results Point of Contact
- Title
- Kevin C. Dellsperger, MD, PhD, Professor, Internal Medicine
- Organization
- University of Missouri
Study Officials
- PRINCIPAL INVESTIGATOR
Tom R Thomas, PhD
University of Missouri-Columbia
- STUDY DIRECTOR
Kevin C Dellsperger, MD, PhD
University of Missouri-Columbia
- STUDY DIRECTOR
Anand Chockalingam, MD
University of Missouri-Columbia
Publication Agreements
- PI is Sponsor Employee
- Yes
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 11, 2007
First Posted
October 15, 2007
Study Start
October 1, 2007
Primary Completion
October 1, 2008
Study Completion
October 1, 2008
Last Updated
March 1, 2017
Results First Posted
November 22, 2016
Record last verified: 2016-11