Dynamic Magnetic Resonance (MR) Study in Evaluating the Vertebral Bone Marrow Perfusion and Its Related Research

NCT00172224 | Completed DMC

• 3 other identifiers: 32244NSC 91-2314-B-002-395NSC 92-2314-B-002-172
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The etiology and pathogenesis of osteoporosis has been extensively discussed. The relationship between bone blood circulation and the formation of bony trabeculae has been less understood. There is plenty of indirect evidence highly suggestive of the correlation between these two factors, such as: the number of blood vessels in the per unit area of the bone marrow was decreased in the osteoporotic bone, indicating the possible role of a microvascular defect in the pathogenesis of osteoporosis. Furthermore, the bone mineral density in severe arteriosclerotic patients was lower than in the less affected subjects. In a large scale epidemiologic study, diminished bone mineral density was strongly associated with increased deaths from stroke. Osteopenia was also associated with an increased risk of stroke. These reports highly suggest the effect of ischemia on bone metabolism and make the investigators more interested in further investigation. A dynamic contrast-enhanced magnetic resonance (MR) study was used recently in evaluating the blood perfusion of bone tumors. This method also has a strong correlation with the microsphere blood flow measurements. The investigator (T.F. Shih) used the dynamic MR in her recent two researches:

1. 1.To differentiate benign versus malignant spinal compression fractures.
2. 2.To evaluate the blood perfusion of non-fractured, normal-appearing vertebral bodies and find its significant correlation with aging and sex.

Conditions

Osteoporosis; Fractures, Compression

Keywords

osteoporosis; compression fracture; bone marrow perfusion; MR spectroscopy; hormone therapy

Study Arms (1)

osteoporosis

Eligibility Criteria

• Age: 40 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

subjects with osteoporosis

You may qualify if:

• Normal subjects
• Elder subjects with osteoporosis

You may not qualify if:

• History of malignancy or infection

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

Tiffany Ting-Fang Shih

Taipei, Taiwan

Location

MeSH Terms

Conditions

Osteoporosis; Fractures, Compression

Condition Hierarchy (Ancestors)

Bone Diseases, Metabolic; Bone Diseases; Musculoskeletal Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases; Fractures, Bone; Wounds and Injuries

Study Officials

• Tiffany Ting-Fang Shih, M.D.

  Department of Medical Image, National Taiwan University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 12, 2005
• First Posted: September 15, 2005
• Study Start: August 1, 2002
• Last Updated: November 14, 2012

Record last verified: 2012-11

Locations

TW (1)