Genetic Liability in the Brain Morphology of Attention Deficit Hyperactivity Disorder

NCT00161161 | Completed

• 1 other identifier: WOM 99/076
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

Attention Deficit Hyperactivity Disorder (ADHD) is a heritable psychiatric disorder with onset in childhood. Twin and adoption studies indicate that additive genetic factors explain up to 80% of the variance underlying susceptibility. The siblings of children with ADHD have a three- to fivefold increased risk of having ADHD compared to the siblings of healthy control subjects, and the risk is even greater for monozygotic twins with 50-80% concordance compared with up to 33% in dizygotic twins). As full siblings share on average 50% of their genes, even the unaffected siblings of children with ADHD would be expected to share some of the genes involved in the disorder. The neuroanatomical substrate of ADHD is becoming increasingly better defined by a growing body of evidence from imaging studies. Evidence from neuroimaging studies suggests that this disorder is associated with reductions in brain volume up to 5% in these children. In this protocol we collected MRI-scans from boys with ADHD and their unaffected siblings, as well as control subjects. In addition, cheekswabs were later collected for DNA analysis.

Conditions

Attention Deficit Hyperactivity Disorder

Keywords

ADHD; MRI; genetics

Eligibility Criteria

• Age: 7 Years - 18 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• age 7 - 18 years.
• DSM-IV (APA, 1994) diagnosis of ADHD (combined subtype), according to DISC interview
• scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF)
• no DSM-IV (APA,1994) diagnosis for ADHD or another disruptive disorder (ODD or CD), according to DISC interview
• no scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF)
• no DSM-IV (APA, 1994) diagnosis, according to DISC interview
• no scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF)

You may not qualify if:

• IQ \< 70
• illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system
• the presence of metal objects in or around the body (pacemaker, dental braces)

Sponsors & Collaborators

• UMC Utrecht: lead
• The Dutch Brain Foundation: collaborator

Study Sites (1)

UMC Utrecht

Utrecht, 3584CX, Netherlands

Location

Related Publications (2)

• Durston S, Hulshoff Pol HE, Schnack HG, Buitelaar JK, Steenhuis MP, Minderaa RB, Kahn RS, van Engeland H. Magnetic resonance imaging of boys with attention-deficit/hyperactivity disorder and their unaffected siblings. J Am Acad Child Adolesc Psychiatry. 2004 Mar;43(3):332-40. doi: 10.1097/00004583-200403000-00016.

  PMID: 15076267 RESULT

• Durston S, Fossella JA, Casey BJ, Hulshoff Pol HE, Galvan A, Schnack HG, Steenhuis MP, Minderaa RB, Buitelaar JK, Kahn RS, van Engeland H. Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with attention deficit hyperactivity disorder, their unaffected siblings, and controls. Mol Psychiatry. 2005 Jul;10(7):678-85. doi: 10.1038/sj.mp.4001649.

  PMID: 15724142 RESULT

MeSH Terms

Conditions

Attention Deficit Disorder with Hyperactivity

Condition Hierarchy (Ancestors)

Attention Deficit and Disruptive Behavior Disorders; Neurodevelopmental Disorders; Mental Disorders

Study Officials

• Sarah Durston, Ph.D.

  RMI of Neuroscience, UMC Utrecht

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: OTHER
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: September 8, 2005
• First Posted: September 12, 2005
• Study Start: October 1, 1999
• Study Completion: December 1, 2002
• Last Updated: December 30, 2005

Record last verified: 2005-09

Locations

NL (1)