NCT00143832

Brief Summary

Poor inhibitory control has been proposed to be central to the cognitive deficits and symptomatology associated with Attention Deficit Hyperactivity Disorder (ADHD). ADHD is a highly heritable disorder with an increased incidence among the siblings of affected individuals. In the current proposal we investigate the expression of genetic susceptibility for ADHD in brain functioning. We will study cognitive functioning in patients with ADHD, their unaffected siblings and healthy matched controls. Our aims are 1) to determine whether increased familial risk for ADHD is associated with differential patterns of brain activation compared to normally developing children, during the performance of tasks designed to probe cognitive functions that are compromised in ADHD and 2) to determine whether differential patterns of activation are similar for boys with ADHD and their unaffected siblings.

Trial Health

55
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Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
90

participants targeted

Target at P50-P75 for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2004

Completed
12 months until next milestone

First Submitted

Initial submission to the registry

August 31, 2005

Completed
2 days until next milestone

First Posted

Study publicly available on registry

September 2, 2005

Completed
Last Updated

March 20, 2007

Status Verified

March 1, 2007

First QC Date

August 31, 2005

Last Update Submit

March 18, 2007

Conditions

Attention Deficit Hyperactivity Disorder

Keywords

fMRI

Eligibility Criteria

Age8 Years - 20 Years
Sexmale
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • Age 8 - 20 years
  • Male
  • DSM-IV (APA, 1994) diagnosis of ADHD, according to DISC interview
  • Scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form(TRF)
  • No DSM-IV (APA, 1994) diagnosis according to DISC interview
  • No scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF)
  • No DSM-IV (APA, 1994) diagnosis, according to DISC interview
  • No scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF)

You may not qualify if:

  • IQ \< 70
  • Illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system
  • Presence of metal objects in or around the body (pacemaker, dental braces)
  • History of or present neurological disorder
  • For individuals over 12 years of age: legal incompetence, defined as the obvious inability to comprehend the information that is presented by the investigator and is outlined in the Information letter and on which the decision to participate in the study is to be based

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Dept. of Child and Adolescent Psychiatry, UMC Utrecht

Utrecht, Netherlands

RECRUITING

Related Publications (2)

  • Durston S, Mulder M, Casey BJ, Ziermans T, van Engeland H. Activation in ventral prefrontal cortex is sensitive to genetic vulnerability for attention-deficit hyperactivity disorder. Biol Psychiatry. 2006 Nov 15;60(10):1062-70. doi: 10.1016/j.biopsych.2005.12.020. Epub 2006 May 19.

    PMID: 16712804RESULT

  • Durston S, Fossella JA, Mulder MJ, Casey BJ, Ziermans TB, Vessaz MN, VAN Engeland H. Dopamine transporter genotype conveys familial risk of attention-deficit/hyperactivity disorder through striatal activation. J Am Acad Child Adolesc Psychiatry. 2008 Jan;47(1):61-67. doi: 10.1097/chi.0b013e31815a5f17.

    PMID: 18174826DERIVED

Related Links

MeSH Terms

Conditions

Attention Deficit Disorder with Hyperactivity

Condition Hierarchy (Ancestors)

Attention Deficit and Disruptive Behavior DisordersNeurodevelopmental DisordersMental Disorders

Study Officials

  • Sarah Durston, Ph.D.

    RMI of Neuroscience, UMC Utrecht

    PRINCIPAL INVESTIGATOR

  • Herman van Engeland, M.D. Ph.D.

    RMI of Neuroscience, UMC Utrecht

    STUDY CHAIR

Central Study Contacts

Sarah Durston, Ph.D.

CONTACT

+31 30 250 8161S.Durston@umcutrecht.nl

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
OTHER
Sponsor Type
OTHER

Study Record Dates

First Submitted

August 31, 2005

First Posted

September 2, 2005

Study Start

September 1, 2004

Last Updated

March 20, 2007

Record last verified: 2007-03

Locations

NL(1)