NCT00026546|Completed
Behavior in Children With Attention Deficit Hyperactivity Disorder and in Healthy Volunteers
A Behavioral and Functional Neuroimaging Study of Inhibitory Motor Control
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A Behavioral and Functional Neuroimaging Study of Inhibitory Motor Control
Sponsor study identifier
Secondary identifiers
observational
189
1 country
1
Study Start
November 7, 2001
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
October 9, 2018
Date type not reportedThis date has not been verified as actual or estimated.
The purpose of this study is to determine how the brain controls motor activity in children with attention deficit hyperactivity disorder (ADHD). The inability to control one s behavior is an important symptom of many psychiatric illnesses. The stop signal paradigm which involves withholding a motor response to a go signal, has proved useful in assessing uncontrolled behavior in children with ADHD and other disorders. This study will use a stop signal paradigm in order to evaluate the ability of children with and without ADHD to control their motor behavior. A magnetic resonance imaging (MRI) scan will be used to study how the brain works during specific activities. This study will evaluate the stop signal paradigm in three groups of people: healthy children, children with ADHD, and healthy adults. This study comprises two sub-studies: a behavioral study in which participants perform simple activities and an MRI study. Participants will be asked to stop any over-the-counter medication 5 days before entering the behavioral or MRI study. Children with ADHD will be asked to stop taking medication for ADHD 72 hours before the study. All participants will have a medical history and a psychiatric evaluation (for children, both parents and children provide information for the assessment). Participants in the MRI study will also have physical examinations and blood and urine tests. All children will undergo intelligence tests; and those with ADHD will have tests to confirm the diagnosis. The parents of child participants will complete an autism screening questionnaire.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
October 9, 2018
Date type not reportedThis date has not been verified as actual or estimated.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
November 7, 2001
Date type not reportedThis date has not been verified as actual or estimated.
November 9, 2001
Actual (reported)November 12, 2001
Actual (reported)October 9, 2018
Date type not reportedThis date has not been verified as actual or estimated.
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, 20892, United States
Oosterlaan J, Logan GD, Sergeant JA. Response inhibition in AD/HD, CD, comorbid AD/HD + CD, anxious, and control children: a meta-analysis of studies with the stop task. J Child Psychol Psychiatry. 1998 Mar;39(3):411-25.
Casey BJ, Giedd JN, Thomas KM. Structural and functional brain development and its relation to cognitive development. Biol Psychol. 2000 Oct;54(1-3):241-57. doi: 10.1016/s0301-0511(00)00058-2.
Ellen Leibenluft, M.D.
National Institute of Mental Health (NIMH)
189 participants (actual enrollment reported by the registry).
First Submitted
November 9, 2001
First Posted
November 12, 2001
Study Start
November 7, 2001
Date type not reportedThis date has not been verified as actual or estimated.
Stimulant Drug Treatment of Attention-Deficit Hyperactivity Disorder (AD/HD), Inattentive Type
Contact the study team to confirm eligibility.
Alexander GE, Crutcher MD, DeLong MR. Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions. Prog Brain Res. 1990;85:119-46.
Study Completion
October 9, 2018
Date type not reportedThis date has not been verified as actual or estimated.
Last Updated
December 12, 2019
Record last verified: 2018-10-09
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