Malaria Birth Cohort (MBC) in Agogo, Ghana
MBC
Analysis of Anti-malarial Immunity Development in Early Life in a Prospective Birth Cohort in Agogo, Ghana
1 other identifier
observational
1,800
1 country
1
Brief Summary
Malaria is a major health threat worldwide with an estimated 229 million cases and 409,000 deaths in 2019 (WHO, World Malaria Report 2019). Vulnerable are young children and pregnant women. The study aims to investigate immunity development against malaria with regard to parasite, human, and socioeconomic factors and possible correlations with pathology or protection in a prospective birth cohort.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Apr 2019
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 8, 2019
CompletedFirst Submitted
Initial submission to the registry
August 5, 2019
CompletedFirst Posted
Study publicly available on registry
August 8, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2025
CompletedSeptember 1, 2021
August 1, 2021
6 years
August 5, 2019
August 27, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Malaria episodes
Frequency and severity of malaria episodes as identified by microscopy, PCR, and clinical criteria.
First 36 months of life
Secondary Outcomes (1)
T cell repertoire
First 36 months of life
Study Arms (2)
Mothers
900 mothers recruited during pregnancy
Children
900 children born to the recruited mothers
Eligibility Criteria
Pregnant women visiting Agogo Presbyterian Hospital (APH) for their antenatal care visit and the newborn children born to these mothers
You may qualify if:
- Catchment area of the EPI (Expanded Program of Immunization) centres with good accessibility to Agogo Prespyterian Hospital (APH)
- Willingness and able to give informed consent for herself and her child
You may not qualify if:
- Maternal age below 18 years
- Positive HIV status of mother
- Refusal or withdrawal of informed consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Bernhard Nocht Institute for Tropical Medicinelead
- Kwame Nkrumah University of Science and Technologycollaborator
- Kumasi Centre for Collaborative Research (KCCR)collaborator
- Heidelberg Universitycollaborator
- KEMRI-Wellcome Trust Collaborative Research Programcollaborator
- Agogo Presbyterian Hospitalcollaborator
Study Sites (1)
Agogo Presbyterian Hospital
Agogo, Ghana
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Jürgen May, Prof
Bernhard Nocht Institute for Tropical Medicine
- STUDY DIRECTOR
John H Amuasi, Dr
Kwame Nkrumah University of Science & Technology (KNUST)
- PRINCIPAL INVESTIGATOR
Eva Mertens, PhD
Bernhard Nocht Institute for Tropical Medicine
- PRINCIPAL INVESTIGATOR
Nicole Struck, PhD
Bernhard Nocht Institute for Tropical Medicine
- PRINCIPAL INVESTIGATOR
Oumou Maiga-Ascofaré, PhD
Kumasi Centre for Collaborative Research
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER GOV
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor, Department Head
Study Record Dates
First Submitted
August 5, 2019
First Posted
August 8, 2019
Study Start
April 8, 2019
Primary Completion
April 1, 2025
Study Completion
April 1, 2025
Last Updated
September 1, 2021
Record last verified: 2021-08
Data Sharing
- IPD Sharing
- Will not share