NCT00127270

Brief Summary

This study is designed to investigate the efficacy and safety of treatment of overactive bladder with darifenacin administered alone or in conjunction with behavioral modification therapies.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
395

participants targeted

Target at P75+ for phase_4

Timeline
Completed

Started May 2005

Shorter than P25 for phase_4

Geographic Reach
1 country

67 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2005

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

June 30, 2005

Completed
1 month until next milestone

First Posted

Study publicly available on registry

August 5, 2005

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2006

Completed
Last Updated

January 24, 2008

Status Verified

January 1, 2008

First QC Date

June 30, 2005

Last Update Submit

January 23, 2008

Conditions

Keywords

OABOveractive BladderBladder hyperactivityUrge IncontinenceIncontinenceBladder

Outcome Measures

Primary Outcomes (1)

  • Change from baseline in average number of urinations per patient per day at Week 12

Secondary Outcomes (3)

  • Change from baseline in average number of urination episodes per patient per day at Week 2, Week 6

  • Change from baseline in average number of urge urinary incontinence episodes, urgency episodes, incontinence pads, and nocturnal urinations per day measured at Weeks 2, 6, 12

  • Quality of Life (baseline, Week 6, Week 12)

Study Arms (2)

1

EXPERIMENTAL

Darifenacin

Drug: Darifenacin

2

OTHER

Darifenacin in combination with Behavioral Modification Programme for Symptoms of Overactive Bladder

Drug: DarifenacinBehavioral: Behavioral therapy

Interventions

Darifenacin tablets 7,5 mg once daily with the possibility to up-titrate to 15 mg once daily

Also known as: Enablex
1

Behavioral Modification Programme for symptoms of overactive bladder

2

Eligibility Criteria

Age18 Years+
Sexall
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Symptoms of overactive bladder
  • Capable of independent toileting and completing a micturition diary
  • Able to comprehend English and follow study procedures and instructions

You may not qualify if:

  • Post void residual \> 100ml/sec
  • Urine flow rate (Qmax) \<10ml/sec for males only

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (67)

Alabama Research Center

Birmingham, Alabama, 35209, United States

Location

Quality of Life Medical & Research

Tucson, Arizona, 85712, United States

Location

UCLA - Urology Sciences Research Foundation

Culver City, California, 90232, United States

Location

San Diego Center for Urology Care

La Mesa, California, 91942, United States

Location

Orange County Urology Associates

Laguna Woods, California, 92653, United States

Location

Atlantic Urology Medical Group

Long Beach, California, 90806, United States

Location

California Professional Research

Newport Beach, California, 92660, United States

Location

Private Practice

North Hollywood, California, 91607, United States

Location

Medical Center for Clinical Research

San Diego, California, 92108, United States

Location

Encompass Clinical Research

Spring Valley, California, 91978, United States

Location

Western Clinical Research

Torrance, California, 90505, United States

Location

Urology Research Options

Aurora, Colorado, 80012, United States

Location

Western Urologic Associates

Wheat Ridge, Colorado, 80033, United States

Location

Connecticut Clinical Research Center

Waterbury, Connecticut, 06708, United States

Location

South Florida Medical Research

Aventura, Florida, 33180, United States

Location

Advance Research Institute

New Port Richey, Florida, 34652, United States

Location

Florida Healthcare Research

Ocala, Florida, 34474, United States

Location

Winter Park Urology Associates

Orlando, Florida, 32803, United States

Location

Atlanta Medical Research Institute

Alpharetta, Georgia, 30005, United States

Location

Shepard Center

Atlanta, Georgia, 30309, United States

Location

Deerpath Physicians Group

Gurnee, Illinois, 60031, United States

Location

RMD Clinical Research Institute

Melrose Park, Illinois, 60160, United States

Location

Southern Illinois Clinical Research Center

O'Fallon, Illinois, 62269, United States

Location

Springfield Clinic

Springfield, Illinois, 62701, United States

Location

Welborn Clinic

Evansville, Indiana, 47714, United States

Location

Urology of Indiana

Indianapolis, Indiana, 46254, United States

Location

Metropolitan Urology

Jeffersonville, Indiana, 47130, United States

Location

Urologic Surgery Associates

Overland Park, Kansas, 66215, United States

Location

Pratt Internal Medicine Group

Pratt, Kansas, 67124, United States

Location

Cotton-O'Neil Clinic

Topeka, Kansas, 66606, United States

Location

Hearthland Research Associates

Wichita, Kansas, 67207, United States

Location

Adult and Pediatric Urology

Saint Cloud, Minnesota, 56303, United States

Location

Mississippi Urology Clinical Research

Jackson, Mississippi, 39202, United States

Location

PPS Clinical Research

St Louis, Missouri, 63141, United States

Location

Washing Univ School of Medicine - Urologic Research Center

St Louis, Missouri, 63141, United States

Location

Women's Clinic of Lincoln

Lincoln, Nebraska, 68510, United States

Location

Quality Clinical Research

Omaha, Nebraska, 68131, United States

Location

Meridian Clinical Research

Omaha, Nebraska, 68134, United States

Location

Lawrenceville Urology

Lawrenceville, New Jersey, 08648, United States

Location

Center for Urologic Care

Voorhees Township, New Jersey, 08043, United States

Location

Central New York Clinical Research

Manlius, New York, 13104, United States

Location

Hudson Valley Urology

Poughkeepsie, New York, 12601, United States

Location

Jacobi Medical Center

The Bronx, New York, 10461, United States

Location

Northeast Urology Research

Concord, North Carolina, 28025, United States

Location

Multi Specialty Research Associates of NC

Raleigh, North Carolina, 27609, United States

Location

Piedmont Medical Research Associates

Winston-Salem, North Carolina, 27103, United States

Location

Private Practice

Edmond, Oklahoma, 73034, United States

Location

Southern Oregon Health and Wellness

Medford, Oregon, 97504, United States

Location

Portland Clinic

Portland, Oregon, 97205, United States

Location

Williamette Women's Health

Tualatin, Oregon, 97232, United States

Location

Univ. of Pittsburgh Medical Center- Dept of Urology

Pittsburgh, Pennsylvania, 15213, United States

Location

Research Protocol Management Specialists

Pittsburgh, Pennsylvania, 15243, United States

Location

South Carolina Clinical Research Center

Columbia, South Carolina, 29201, United States

Location

Doctors for Women

Nashville, Tennessee, 37203, United States

Location

Medical Arts Clinic

Corsicana, Texas, 75110, United States

Location

Radiant Research

Dallas, Texas, 75231, United States

Location

Urology Clinics of North Texas

Dallas, Texas, 75231, United States

Location

Advances in Health

Houston, Texas, 77030, United States

Location

Kelsey Seybold Research Foundation

Houston, Texas, 77054, United States

Location

R/D Clinical Research

Lake Jackson, Texas, 77566, United States

Location

Progressive Clinical Research

Centerville, Utah, 84014, United States

Location

Intermountain Clinical Research

Salt Lake City, Utah, 84102, United States

Location

Salt Lake Research

Salt Lake City, Utah, 84124, United States

Location

Virginia Urology

Richmond, Virginia, 23235, United States

Location

East Coast Clinical Research

Virginia Beach, Virginia, 23454, United States

Location

Radiant Research

Lakewood, Washington, 98499, United States

Location

Valley Women's Clinic

Renton, Washington, 98055, United States

Location

Related Publications (1)

  • Funada S, Yoshioka T, Luo Y, Sato A, Akamatsu S, Watanabe N. Bladder training for treating overactive bladder in adults. Cochrane Database Syst Rev. 2023 Oct 9;10(10):CD013571. doi: 10.1002/14651858.CD013571.pub2.

MeSH Terms

Conditions

Urinary IncontinenceUrinary Bladder, OveractiveUrinary Incontinence, Urge

Interventions

darifenacinBehavior Therapy

Condition Hierarchy (Ancestors)

Urination DisordersUrologic DiseasesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital DiseasesLower Urinary Tract SymptomsUrological ManifestationsSigns and SymptomsPathological Conditions, Signs and SymptomsUrinary Bladder Diseases

Intervention Hierarchy (Ancestors)

PsychotherapyBehavioral Disciplines and Activities

Study Officials

  • Novartis Pharmaceuticals Corp.

    Novartis Pharmaceutical

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 4
Allocation
RANDOMIZED
Masking
NONE
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY

Study Record Dates

First Submitted

June 30, 2005

First Posted

August 5, 2005

Study Start

May 1, 2005

Study Completion

February 1, 2006

Last Updated

January 24, 2008

Record last verified: 2008-01

Locations