A Study of Gene Polymorphisms and Normal Tissue Radiation Injury in Patients Treated for Breast, Prostate, Brain, Lung, and Head and Neck Cancers

NCT00122239 | Unknown DMC

• 1 other identifier: SP-14-0043 / ethics 21725
• Study Type: observational
• Target: 13
• Locations: 1 country
• Sites: 1

Brief Summary

This study will examine, for the first time, the independent contribution of a patient's own genetic makeup to the development of post-radiation complications, permitting the future development of predictive tests to avoid radiation injury. To do this, the investigators will examine gene markers in a series of breast, prostate, brain and lung cancer survivors who have received conformal radiotherapy between 1996 and 2003 at the Cross Cancer Institute and Tom Baker Cancer Centre.

Conditions

Breast Cancer; Glioma; Prostate Cancer; Carcinoma, Squamous Cell; Carcinoma, Non-Small-Cell-Lung; Head and Neck Cancer

Keywords

radiotherapy; radiation toxicity; single nucleotide polymorphism; breast carcinoma; prostate carcinoma; squamous cell carcinoma of the head and neck; lung carcinoma (non-small cell)

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients will be selected consecutively if they have undergone a course of radical radiotherapy.

You may qualify if:

• Breast cancer
• Prostate cancer
• Squamous cell carcinoma (SCC) of the head and neck
• Non-small-cell-lung carcinoma (NSCLC)
• Glioma treated by radiotherapy

You may not qualify if:

• Follow-up less than 18 months

Sponsors & Collaborators

• AHS Cancer Control Alberta: lead
• Cross Cancer Institute: collaborator

Study Sites (1)

Cross Cancer Institute

Edmonton, Alberta, T6G 1Z2, Canada

Location

MeSH Terms

Conditions

Breast Neoplasms; Glioma; Prostatic Neoplasms; Carcinoma, Squamous Cell; Carcinoma, Non-Small-Cell Lung; Head and Neck Neoplasms; Radiation Injuries; Squamous Cell Carcinoma of Head and Neck

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases; Neoplasms, Neuroepithelial; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms, Glandular and Epithelial; Neoplasms, Nerve Tissue; Genital Neoplasms, Male; Urogenital Neoplasms; Genital Diseases, Male; Genital Diseases; Urogenital Diseases; Prostatic Diseases; Male Urogenital Diseases; Carcinoma; Neoplasms, Squamous Cell; Carcinoma, Bronchogenic; Bronchial Neoplasms; Lung Neoplasms; Respiratory Tract Neoplasms; Thoracic Neoplasms; Lung Diseases; Respiratory Tract Diseases; Wounds and Injuries

Study Officials

• Matthew Parliament, MD

  Cross Cancer Institute

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 20, 2005
• First Posted: July 22, 2005
• Study Start: January 1, 2005
• Primary Completion: February 1, 2017
• Study Completion: February 1, 2017
• Last Updated: March 16, 2016

Record last verified: 2016-03

Locations

CA (1)