NCT00093470

Brief Summary

This randomized phase III trial studies tipifarnib in treating patients with acute myeloid leukemia (AML) in remission. Tipifarnib may stop the growth of cancer cells by blocking the enzymes necessary for their growth. It is not yet known whether tipifarnib is more effective than observation alone in preventing the recurrence of AML.

Trial Health

85
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
144

participants targeted

Target at P25-P50 for phase_3

Geographic Reach
3 countries

341 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 18, 2004

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

October 6, 2004

Completed
2 days until next milestone

First Posted

Study publicly available on registry

October 8, 2004

Completed
10.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 20, 2015

Completed
9 months until next milestone

Results Posted

Study results publicly available

November 10, 2015

Completed
Last Updated

March 20, 2024

Status Verified

March 1, 2024

Enrollment Period

10.5 years

First QC Date

October 6, 2004

Results QC Date

October 13, 2015

Last Update Submit

March 18, 2024

Conditions

Outcome Measures

Primary Outcomes (1)

  • Disease-free Survival

    Disease-free survival (DFS) is defined as the time from randomization to relapse or death without relapse.

    Assessed monthly for the first 6 months then every 3 months or as clinically indicated, up to 5 years.

Secondary Outcomes (1)

  • Overall Survival

    Assessed monthly for the first 6 months then every 3 months or as clinically indicated, up to 5 years.

Study Arms (2)

Arm A (tipifarnib)

EXPERIMENTAL

Patients receive tipifarnib PO BID on days 1-21. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

Drug: Tipifarnib

Arm B (clinical observation)

OTHER

Patients undergo observation only.

Procedure: Clinical Observation

Interventions

Undergo observation

Also known as: observation
Arm B (clinical observation)

Given PO

Also known as: R115777, Zarnestra
Arm A (tipifarnib)

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Patients eligible to enter this study must fall into one of these categories:
  • Patients in first remission following primary induction failure
  • Patients must have received at least two chemotherapy induction regimens
  • Patients in second or subsequent remission
  • Patients \> 60 years old in first remission
  • Patients must be in complete remission (CR) or morphologic remission (MR) by blood counts and bone marrow studies to enter the study
  • Confirmatory bone marrow must be performed =\< 2 weeks prior to randomization
  • Patients must have morphologic proof (from bone marrow aspirate, smears or touch preps of marrow biopsy) that they had AML of one of the following types prior to achievement of CR/MR
  • Acute myeloblastic leukemia, minimal differentiation (French-American-British \[FAB\] M0)
  • Acute myeloblastic leukemia without differentiation (FAB M1)
  • Acute myeloblastic leukemia with maturation (FAB M2)
  • Acute myelomonocytic leukemia (FAB M4)
  • Acute monocytic leukemia (FAB M5)
  • Acute erythroleukemia (FAB M6)
  • Acute megakaryocytic leukemia (FAB M7)
  • +26 more criteria

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (341)

University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, 35233, United States

Location

Providence Alaska Medical Center

Anchorage, Alaska, 99508, United States

Location

Mayo Clinic in Arizona

Scottsdale, Arizona, 85259, United States

Location

Kaiser Permanente-San Diego Mission

San Diego, California, 92108, United States

Location

The Medical Center of Aurora

Aurora, Colorado, 80012, United States

Location

Boulder Community Hospital

Boulder, Colorado, 80301, United States

Location

Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, 80907, United States

Location

Porter Adventist Hospital

Denver, Colorado, 80210, United States

Location

Presbyterian - Saint Lukes Medical Center - Health One

Denver, Colorado, 80218, United States

Location

SCL Health Saint Joseph Hospital

Denver, Colorado, 80218, United States

Location

Rose Medical Center

Denver, Colorado, 80220, United States

Location

Colorado Cancer Research Program NCORP

Denver, Colorado, 80222, United States

Location

Swedish Medical Center

Englewood, Colorado, 80113, United States

Location

Poudre Valley Hospital

Fort Collins, Colorado, 80524, United States

Location

Saint Mary's Hospital and Regional Medical Center

Grand Junction, Colorado, 81501, United States

Location

North Colorado Medical Center

Greeley, Colorado, 80631, United States

Location

Saint Anthony Hospital

Lakewood, Colorado, 80228, United States

Location

Sky Ridge Medical Center

Lone Tree, Colorado, 80124, United States

Location

Longmont United Hospital

Longmont, Colorado, 80501, United States

Location

McKee Medical Center

Loveland, Colorado, 80539, United States

Location

Saint Mary Corwin Medical Center

Pueblo, Colorado, 81004, United States

Location

North Suburban Medical Center

Thornton, Colorado, 80229, United States

Location

SCL Health Lutheran Medical Center

Wheat Ridge, Colorado, 80033, United States

Location

Smilow Cancer Hospital-Torrington Care Center

Torrington, Connecticut, 06790, United States

Location

Beebe Medical Center

Lewes, Delaware, 19958, United States

Location

Christiana Care Health System-Christiana Hospital

Newark, Delaware, 19718, United States

Location

Saint Francis Hospital - Wilmington

Wilmington, Delaware, 19805, United States

Location

MedStar Georgetown University Hospital

Washington D.C., District of Columbia, 20007, United States

Location

MedStar Washington Hospital Center

Washington D.C., District of Columbia, 20010, United States

Location

Boca Raton Regional Hospital

Boca Raton, Florida, 33486, United States

Location

Holy Cross Hospital

Fort Lauderdale, Florida, 33308, United States

Location

Broward Health Medical Center

Fort Lauderdale, Florida, 33316, United States

Location

University of Florida Health Science Center - Gainesville

Gainesville, Florida, 32610, United States

Location

Memorial Regional Hospital/Joe DiMaggio Children's Hospital

Hollywood, Florida, 33021, United States

Location

Baptist MD Anderson Cancer Center

Jacksonville, Florida, 32207, United States

Location

Jupiter Medical Center

Jupiter, Florida, 33458, United States

Location

University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136, United States

Location

Mount Sinai Medical Center

Miami Beach, Florida, 33140, United States

Location

Phoebe Putney Memorial Hospital

Albany, Georgia, 31701, United States

Location

University Cancer and Blood Center LLC

Athens, Georgia, 30607, United States

Location

Augusta University Medical Center

Augusta, Georgia, 30912, United States

Location

Memorial University Medical Center

Savannah, Georgia, 31404, United States

Location

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, 31405, United States

Location

Hematology Oncology Associates of Eastern Idaho

Idaho Falls, Idaho, 83404, United States

Location

Rush - Copley Medical Center

Aurora, Illinois, 60504, United States

Location

Saint Joseph Medical Center

Bloomington, Illinois, 61701, United States

Location

Graham Hospital Association

Canton, Illinois, 61520, United States

Location

Memorial Hospital

Carthage, Illinois, 62321, United States

Location

Hematology and Oncology Associates

Chicago, Illinois, 60611, United States

Location

Northwestern University

Chicago, Illinois, 60611, United States

Location

Jesse Brown Veterans Affairs Medical Center

Chicago, Illinois, 60612, United States

Location

Rush University Medical Center

Chicago, Illinois, 60612, United States

Location

Mercy Hospital and Medical Center

Chicago, Illinois, 60616, United States

Location

Swedish Covenant Hospital

Chicago, Illinois, 60625, United States

Location

University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637, United States

Location

Decatur Memorial Hospital

Decatur, Illinois, 62526, United States

Location

Heartland Cancer Research NCORP

Decatur, Illinois, 62526, United States

Location

Eureka Hospital

Eureka, Illinois, 61530, United States

Location

NorthShore University HealthSystem-Evanston Hospital

Evanston, Illinois, 60201, United States

Location

Galesburg Cottage Hospital

Galesburg, Illinois, 61401, United States

Location

Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401, United States

Location

Western Illinois Cancer Treatment Center

Galesburg, Illinois, 61401, United States

Location

Mason District Hospital

Havana, Illinois, 62644, United States

Location

Hinsdale Hematology Oncology Associates Incorporated

Hinsdale, Illinois, 60521, United States

Location

Hopedale Medical Complex - Hospital

Hopedale, Illinois, 61747, United States

Location

Midwest Center for Hematology Oncology

Joliet, Illinois, 60432, United States

Location

Joliet Oncology-Hematology Associates Limited

Joliet, Illinois, 60435, United States

Location

Kewanee Hospital

Kewanee, Illinois, 61443, United States

Location

Deerpath Medical Associates

Lake Forest, Illinois, 60045, United States

Location

NorthShore Hematology Oncology-Libertyville

Libertyville, Illinois, 60048, United States

Location

Mcdonough District Hospital

Macomb, Illinois, 61455, United States

Location

Loyola University Medical Center

Maywood, Illinois, 60153, United States

Location

Illinois Cancer Specialists-Niles

Niles, Illinois, 60714, United States

Location

Bromenn Regional Medical Center

Normal, Illinois, 61761, United States

Location

Community Cancer Center Foundation

Normal, Illinois, 61761, United States

Location

Franciscan St. James Health-Olympia Fields Campus

Olympia Fields, Illinois, 60461, United States

Location

Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350, United States

Location

Ottawa Regional Hospital and Healthcare Center

Ottawa, Illinois, 61350, United States

Location

OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center

Pekin, Illinois, 61554, United States

Location

Pekin Hospital

Pekin, Illinois, 61554, United States

Location

Methodist Medical Center of Illinois

Peoria, Illinois, 61603, United States

Location

Proctor Hospital

Peoria, Illinois, 61614, United States

Location

Illinois CancerCare-Peoria

Peoria, Illinois, 61615, United States

Location

OSF Saint Francis Medical Center

Peoria, Illinois, 61637, United States

Location

Illinois Valley Hospital

Peru, Illinois, 61354, United States

Location

Valley Radiation Oncology

Peru, Illinois, 61354, United States

Location

Perry Memorial Hospital

Princeton, Illinois, 61356, United States

Location

Sarah Culbertson Memorial Hospital

Rushville, Illinois, 62681, United States

Location

Edward H Kaplan MD and Associates

Skokie, Illinois, 60076, United States

Location

Hematology Oncology Associates of Illinois - Skokie

Skokie, Illinois, 60076, United States

Location

Midwest Cancer Research Group Incorporated

Skokie, Illinois, 60077, United States

Location

Saint Margaret's Hospital

Spring Valley, Illinois, 61362, United States

Location

Memorial Medical Center

Springfield, Illinois, 62781, United States

Location

Carle Cancer Center

Urbana, Illinois, 61801, United States

Location

Franciscan Saint Francis Health-Beech Grove

Beech Grove, Indiana, 46107, United States

Location

Elkhart General Hospital

Elkhart, Indiana, 46515, United States

Location

Fort Wayne Medical Oncology and Hematology Inc-Parkview

Fort Wayne, Indiana, 46845, United States

Location

Community Howard Regional Health

Kokomo, Indiana, 46904, United States

Location

IU Health La Porte Hospital

La Porte, Indiana, 46350, United States

Location

Franciscan Saint Anthony Health-Michigan City

Michigan City, Indiana, 46360, United States

Location

Saint Joseph Regional Medical Center-Mishawaka

Mishawaka, Indiana, 46545, United States

Location

The Community Hospital

Munster, Indiana, 46321, United States

Location

Memorial Hospital of South Bend

South Bend, Indiana, 46601, United States

Location

Northern Indiana Cancer Research Consortium

South Bend, Indiana, 46628, United States

Location

McFarland Clinic PC-William R Bliss Cancer Center

Ames, Iowa, 50010, United States

Location

University of Iowa Healthcare Cancer Services Quad Cities

Bettendorf, Iowa, 52722, United States

Location

Medical Oncology and Hematology Associates-West Des Moines

Clive, Iowa, 50325, United States

Location

Heartland Oncology and Hematology LLP

Council Bluffs, Iowa, 51503, United States

Location

Genesis Medical Center - East Campus

Davenport, Iowa, 52803, United States

Location

Genesis Medical Center - West Campus

Davenport, Iowa, 52804, United States

Location

Mercy Capitol

Des Moines, Iowa, 50307, United States

Location

Iowa Methodist Medical Center

Des Moines, Iowa, 50309, United States

Location

Iowa-Wide Oncology Research Coalition NCORP

Des Moines, Iowa, 50309, United States

Location

Medical Oncology and Hematology Associates-Des Moines

Des Moines, Iowa, 50309, United States

Location

Medical Oncology and Hematology Associates-Laurel

Des Moines, Iowa, 50314, United States

Location

Mercy Medical Center - Des Moines

Des Moines, Iowa, 50314, United States

Location

Iowa Lutheran Hospital

Des Moines, Iowa, 50316, United States

Location

Siouxland Regional Cancer Center

Sioux City, Iowa, 51101, United States

Location

Mercy Medical Center-Sioux City

Sioux City, Iowa, 51104, United States

Location

Saint Luke's Regional Medical Center

Sioux City, Iowa, 51104, United States

Location

Hospital District Sixth of Harper County

Anthony, Kansas, 67003, United States

Location

Memorial Hospital of Arkansas City

Arkansas City, Kansas, 67005, United States

Location

Cancer Center of Kansas - Chanute

Chanute, Kansas, 66720, United States

Location

Cancer Center of Kansas - Dodge City

Dodge City, Kansas, 67801, United States

Location

Cancer Center of Kansas - El Dorado

El Dorado, Kansas, 67042, United States

Location

Cancer Center of Kansas - Fort Scott

Fort Scott, Kansas, 66701, United States

Location

Cancer Center of Kansas-Independence

Independence, Kansas, 67301, United States

Location

Cancer Center of Kansas-Kingman

Kingman, Kansas, 67068, United States

Location

Lawrence Memorial Hospital

Lawrence, Kansas, 66044, United States

Location

Southwest Medical Center

Liberal, Kansas, 67901, United States

Location

Cancer Center of Kansas - Newton

Newton, Kansas, 67114, United States

Location

Cancer Center of Kansas - Ottawa

Ottawa, Kansas, 66067, United States

Location

Menorah Medical Center

Overland Park, Kansas, 66209, United States

Location

Saint Luke's South Hospital

Overland Park, Kansas, 66213, United States

Location

Cancer Center of Kansas - Parsons

Parsons, Kansas, 67357, United States

Location

Kansas City NCI Community Oncology Research Program

Prairie Village, Kansas, 66208, United States

Location

Cancer Center of Kansas - Pratt

Pratt, Kansas, 67124, United States

Location

Cancer Center of Kansas - Salina

Salina, Kansas, 67401, United States

Location

Shawnee Mission Medical Center-KCCC

Shawnee Mission, Kansas, 66204, United States

Location

Cotton O'Neil Cancer Center / Stormont Vail Health

Topeka, Kansas, 66606, United States

Location

Saint Francis Hospital and Medical Center - Topeka

Topeka, Kansas, 66606, United States

Location

Cancer Center of Kansas - Wellington

Wellington, Kansas, 67152, United States

Location

Associates In Womens Health

Wichita, Kansas, 67208, United States

Location

Cancer Center of Kansas-Wichita Medical Arts Tower

Wichita, Kansas, 67208, United States

Location

Cancer Center of Kansas - Wichita

Wichita, Kansas, 67214, United States

Location

Via Christi Regional Medical Center

Wichita, Kansas, 67214, United States

Location

Wichita NCI Community Oncology Research Program

Wichita, Kansas, 67214, United States

Location

Cancer Center of Kansas - Winfield

Winfield, Kansas, 67156, United States

Location

Baton Rouge General Medical Center

Baton Rouge, Louisiana, 70806, United States

Location

Mary Bird Perkins Cancer Center

Baton Rouge, Louisiana, 70809, United States

Location

Ochsner Health Center-Summa

Baton Rouge, Louisiana, 70809, United States

Location

Mary Bird Perkins Cancer Center/Terrebonne General Medical Center

Houma, Louisiana, 70360, United States

Location

Louisiana State University Health Science Center

New Orleans, Louisiana, 70112, United States

Location

University Medical Center New Orleans

New Orleans, Louisiana, 70112, United States

Location

Ochsner Medical Center Jefferson

New Orleans, Louisiana, 70121, United States

Location

Overton Brooks Veteran's Administration Medical Center

Shreveport, Louisiana, 71101, United States

Location

Louisiana State University Health Sciences Center Shreveport

Shreveport, Louisiana, 71103, United States

Location

Eastern Maine Medical Center

Bangor, Maine, 04401, United States

Location

Maine General Medical Center-Thayer

Waterville, Maine, 04901, United States

Location

Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287, United States

Location

Union Hospital of Cecil County

Elkton, Maryland, 21921, United States

Location

Tufts Medical Center

Boston, Massachusetts, 02111, United States

Location

Boston Medical Center

Boston, Massachusetts, 02118, United States

Location

Lahey Hospital and Medical Center

Burlington, Massachusetts, 01805, United States

Location

Franklin Medical Center

Greenfield, Massachusetts, 01301, United States

Location

Baystate Medical Center

Springfield, Massachusetts, 01199, United States

Location

Henry Ford Hospital

Detroit, Michigan, 48202, United States

Location

Borgess Medical Center

Kalamazoo, Michigan, 49001, United States

Location

Bronson Methodist Hospital

Kalamazoo, Michigan, 49007, United States

Location

West Michigan Cancer Center

Kalamazoo, Michigan, 49007, United States

Location

Kalamazoo Center for Medical Studies

Kalamazoo, Michigan, 49008, United States

Location

William Beaumont Hospital-Royal Oak

Royal Oak, Michigan, 48073, United States

Location

Lakeland Hospital

Saint Joseph, Michigan, 49085, United States

Location

Providence Hospital-Southfield Cancer Center

Southfield, Michigan, 48075, United States

Location

Medini, Eitan MD (UIA Investigator)

Alexandria, Minnesota, 56308, United States

Location

Fairview Ridges Hospital

Burnsville, Minnesota, 55337, United States

Location

Mercy Hospital

Coon Rapids, Minnesota, 55433, United States

Location

Essentia Health Cancer Center

Duluth, Minnesota, 55805, United States

Location

Essentia Health Saint Mary's Medical Center

Duluth, Minnesota, 55805, United States

Location

Miller-Dwan Hospital

Duluth, Minnesota, 55805, United States

Location

Fairview-Southdale Hospital

Edina, Minnesota, 55435, United States

Location

Etzell, Paul S MD (UIA Investigator)

Fergus Falls, Minnesota, 56537, United States

Location

Swenson, Wade II, MD (UIA Investigator)

Fergus Falls, Minnesota, 56537, United States

Location

Unity Hospital

Fridley, Minnesota, 55432, United States

Location

Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, 55109, United States

Location

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States

Location

North Memorial Medical Health Center

Robbinsdale, Minnesota, 55422, United States

Location

Mayo Clinic

Rochester, Minnesota, 55905, United States

Location

Coborn Cancer Center at Saint Cloud Hospital

Saint Cloud, Minnesota, 56303, United States

Location

Saint Cloud Hospital

Saint Cloud, Minnesota, 56303, United States

Location

Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416, United States

Location

United Hospital

Saint Paul, Minnesota, 55102, United States

Location

Saint Francis Regional Medical Center

Shakopee, Minnesota, 55379, United States

Location

Ridgeview Medical Center

Waconia, Minnesota, 55387, United States

Location

Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota, 55125, United States

Location

Hattiesburg Clinic - Hematology/Oncology Clinic

Hattiesburg, Mississippi, 39401, United States

Location

Hematology and Oncology Clinic

Hattiesburg, Mississippi, 39402, United States

Location

Centerpoint Medical Center LLC

Independence, Missouri, 64057, United States

Location

Truman Medical Center

Kansas City, Missouri, 64108, United States

Location

Saint Luke's Hospital of Kansas City

Kansas City, Missouri, 64111, United States

Location

Saint Joseph Health Center

Kansas City, Missouri, 64114, United States

Location

North Kansas City Hospital

Kansas City, Missouri, 64116, United States

Location

Research Medical Center

Kansas City, Missouri, 64132, United States

Location

Saint Luke's East - Lee's Summit

Lee's Summit, Missouri, 64086, United States

Location

Liberty Radiation Oncology Center

Liberty, Missouri, 64068, United States

Location

Heartland Regional Medical Center

Saint Joseph, Missouri, 64507, United States

Location

Washington University School of Medicine

St Louis, Missouri, 63110, United States

Location

Billings Clinic Cancer Center

Billings, Montana, 59101, United States

Location

Northern Rockies Radiation Oncology Center

Billings, Montana, 59101, United States

Location

Saint Vincent Healthcare

Billings, Montana, 59101, United States

Location

Montana Cancer Consortium NCORP

Billings, Montana, 59102, United States

Location

Saint Vincent Frontier Cancer Center

Billings, Montana, 59102, United States

Location

Deaconess Medical Center

Billings, Montana, 59107, United States

Location

Bozeman Deaconess Hospital

Bozeman, Montana, 59715, United States

Location

Internal Medicine of Bozeman

Bozeman, Montana, 59715, United States

Location

Saint James Community Hospital and Cancer Treatment Center

Butte, Montana, 59701, United States

Location

Benefis Healthcare- Sletten Cancer Institute

Great Falls, Montana, 59405, United States

Location

Berdeaux, Donald MD (UIA Investigator)

Great Falls, Montana, 59405, United States

Location

Great Falls Clinic

Great Falls, Montana, 59405, United States

Location

Saint Peter's Community Hospital

Helena, Montana, 59601, United States

Location

Glacier Oncology PLLC

Kalispell, Montana, 59901, United States

Location

Kalispell Medical Oncology

Kalispell, Montana, 59901, United States

Location

Kalispell Regional Medical Center

Kalispell, Montana, 59901, United States

Location

Eastern Montana Cancer Center

Miles City, Montana, 59301, United States

Location

Montana Cancer Specialists

Missoula, Montana, 59802, United States

Location

Saint Patrick Hospital - Community Hospital

Missoula, Montana, 59802, United States

Location

Community Medical Hospital

Missoula, Montana, 59804, United States

Location

Guardian Oncology and Center for Wellness

Missoula, Montana, 59804, United States

Location

University Medical Center of Southern Nevada

Las Vegas, Nevada, 89102, United States

Location

Nevada Cancer Research Foundation CCOP

Las Vegas, Nevada, 89106, United States

Location

Cooper Hospital University Medical Center

Camden, New Jersey, 08103, United States

Location

Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903, United States

Location

Roswell Park Cancer Institute

Buffalo, New York, 14263, United States

Location

Hematology Oncology Associates of Central New York-East Syracuse

East Syracuse, New York, 13057, United States

Location

Orange Regional Medical Center

Middletown, New York, 10940, United States

Location

Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, 10016, United States

Location

Weill Medical College of Cornell University

New York, New York, 10065, United States

Location

Stony Brook University Medical Center

Stony Brook, New York, 11794, United States

Location

Montefiore Medical Center-Weiler Hospital

The Bronx, New York, 10461, United States

Location

Montefiore Medical Center-Wakefield Campus

The Bronx, New York, 10466, United States

Location

Montefiore Medical Center - Moses Campus

The Bronx, New York, 10467, United States

Location

Carolinas Medical Center/Levine Cancer Institute

Charlotte, North Carolina, 28203, United States

Location

Southeastern Medical Oncology Center-Goldsboro

Goldsboro, North Carolina, 27534, United States

Location

Wayne Memorial Hospital

Goldsboro, North Carolina, 27534, United States

Location

Wayne Radiation Oncology

Goldsboro, North Carolina, 27534, United States

Location

Kinston Medical Specialists PA

Kinston, North Carolina, 28501, United States

Location

Rutherford Hospital

Rutherfordton, North Carolina, 28139, United States

Location

Wilson Medical Center

Wilson, North Carolina, 27893, United States

Location

Summa Akron City Hospital/Cooper Cancer Center

Akron, Ohio, 44304, United States

Location

Akron General Medical Center

Akron, Ohio, 44307, United States

Location

Aultman Health Foundation

Canton, Ohio, 44710, United States

Location

The Jewish Hospital

Cincinnati, Ohio, 45236, United States

Location

Case Western Reserve University

Cleveland, Ohio, 44106, United States

Location

MetroHealth Medical Center

Cleveland, Ohio, 44109, United States

Location

Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States

Location

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States

Location

Samaritan North Health Center

Dayton, Ohio, 45415, United States

Location

Cleveland Clinic Cancer Center Independence

Independence, Ohio, 44131, United States

Location

Saint Rita's Medical Center

Lima, Ohio, 45801, United States

Location

Cleveland Clinic Wooster Family Health and Surgery Center

Wooster, Ohio, 44691, United States

Location

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States

Location

Cancer Care Associates

Oklahoma City, Oklahoma, 73120, United States

Location

Natalie Warren Bryant Cancer Center at Saint Francis

Tulsa, Oklahoma, 74136, United States

Location

Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania, 18103, United States

Location

Geisinger Medical Center

Danville, Pennsylvania, 17822, United States

Location

Penn State Milton S Hershey Medical Center

Hershey, Pennsylvania, 17033-0850, United States

Location

Lewistown Hospital

Lewistown, Pennsylvania, 17044, United States

Location

University of Pennsylvania/Abramson Cancer Center

Philadelphia, Pennsylvania, 19104, United States

Location

Pennsylvania Hospital

Philadelphia, Pennsylvania, 19107, United States

Location

Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States

Location

Mercy Hospital

Scranton, Pennsylvania, 18501, United States

Location

Scranton Hematology Oncology

Scranton, Pennsylvania, 18510, United States

Location

Geisinger Medical Group

State College, Pennsylvania, 16801, United States

Location

Mount Nittany Medical Center

State College, Pennsylvania, 16803, United States

Location

Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, Pennsylvania, 18711, United States

Location

WellSpan Health-York Hospital

York, Pennsylvania, 17403, United States

Location

AnMed Health Hospital

Anderson, South Carolina, 29621, United States

Location

McLeod Regional Medical Center

Florence, South Carolina, 29506, United States

Location

Spartanburg Medical Center

Spartanburg, South Carolina, 29303, United States

Location

Sanford Cancer Center Oncology Clinic

Sioux Falls, South Dakota, 57104, United States

Location

Avera Cancer Institute

Sioux Falls, South Dakota, 57105, United States

Location

Avera McKennan Hospital and University Health Center

Sioux Falls, South Dakota, 57105, United States

Location

Medical X-Ray Center

Sioux Falls, South Dakota, 57105, United States

Location

Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134, United States

Location

University of Tennessee - Knoxville

Knoxville, Tennessee, 37920, United States

Location

Brooke Army Medical Center

Fort Sam Houston, Texas, 78234, United States

Location

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, Texas, 77030, United States

Location

Baylor Saint Luke's Medical Center

Houston, Texas, 77030, United States

Location

Ben Taub General Hospital

Houston, Texas, 77030, United States

Location

Michael E DeBakey VA Medical Center

Houston, Texas, 77030, United States

Location

The Methodist Hospital System

Houston, Texas, 77030, United States

Location

Wilford Hall Medical Center

Lackland Air Force Base, Texas, 78236, United States

Location

Sandra L Maxwell Cancer Center

Cedar City, Utah, 84720, United States

Location

Logan Regional Hospital

Logan, Utah, 84321, United States

Location

Cottonwood Hospital Medical Center

Murray, Utah, 84107, United States

Location

Intermountain Medical Center

Murray, Utah, 84107, United States

Location

McKay-Dee Hospital Center

Ogden, Utah, 84403, United States

Location

Utah Valley Regional Medical Center

Provo, Utah, 84604, United States

Location

Intermountain Health Care

Salt Lake City, Utah, 84103, United States

Location

Utah Cancer Specialists-Salt Lake City

Salt Lake City, Utah, 84106, United States

Location

Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112, United States

Location

LDS Hospital

Salt Lake City, Utah, 84143, United States

Location

Dixie Medical Center Regional Cancer Center

St. George, Utah, 84770, United States

Location

Central Vermont Medical Center/National Life Cancer Treatment

Berlin Corners, Vermont, 05602, United States

Location

University of Vermont College of Medicine

Burlington, Vermont, 05405, United States

Location

PeaceHealth Saint Joseph Medical Center

Bellingham, Washington, 98225, United States

Location

Harrison HealthPartners Hematology and Oncology-Bremerton

Bremerton, Washington, 98310, United States

Location

Kadlec Clinic Hematology and Oncology

Kennewick, Washington, 99336, United States

Location

Skagit Valley Hospital

Mount Vernon, Washington, 98274, United States

Location

Harborview Medical Center

Seattle, Washington, 98104, United States

Location

Minor and James Medical PLLC

Seattle, Washington, 98104, United States

Location

Fred Hutchinson Cancer Research Center

Seattle, Washington, 98109, United States

Location

Kaiser Permanente Washington

Seattle, Washington, 98112, United States

Location

Swedish Medical Center-First Hill

Seattle, Washington, 98122-4307, United States

Location

University of Washington Medical Center

Seattle, Washington, 98195, United States

Location

PeaceHealth United General Medical Center

Sedro-Woolley, Washington, 98284, United States

Location

Cancer Care Northwest - Spokane South

Spokane, Washington, 99202, United States

Location

PeaceHealth Southwest Medical Center

Vancouver, Washington, 98664, United States

Location

Central Washington Hospital

Wenatchee, Washington, 98801, United States

Location

Wenatchee Valley Hospital and Clinics

Wenatchee, Washington, 98801, United States

Location

West Virginia University Healthcare

Morgantown, West Virginia, 26506, United States

Location

Marshfield Clinic-Chippewa Center

Chippewa Falls, Wisconsin, 54729, United States

Location

Marshfield Clinic Cancer Center at Sacred Heart

Eau Claire, Wisconsin, 54701, United States

Location

Sacred Heart Hospital

Eau Claire, Wisconsin, 54701, United States

Location

Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601, United States

Location

Marshfield Clinic

Marshfield, Wisconsin, 54449, United States

Location

Marshfield Medical Center

Marshfield, Wisconsin, 54449, United States

Location

Froedtert and the Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States

Location

Marshfield Clinic-Minocqua Center

Minocqua, Wisconsin, 54548, United States

Location

ProHealth Oconomowoc Memorial Hospital

Oconomowoc, Wisconsin, 53066, United States

Location

Ascension Saint Mary's Hospital

Rhinelander, Wisconsin, 54501, United States

Location

Marshfield Clinic-Rice Lake Center

Rice Lake, Wisconsin, 54868, United States

Location

Saint Michael's Hospital

Stevens Point, Wisconsin, 54481, United States

Location

ProHealth Waukesha Memorial Hospital

Waukesha, Wisconsin, 53188, United States

Location

Marshfield Clinic-Wausau Center

Wausau, Wisconsin, 54401, United States

Location

Diagnostic and Treatment Center

Weston, Wisconsin, 54476, United States

Location

Marshfield Clinic - Weston Center

Weston, Wisconsin, 54476, United States

Location

Marshfield Clinic - Wisconsin Rapids Center

Wisconsin Rapids, Wisconsin, 54494, United States

Location

Welch Cancer Center

Sheridan, Wyoming, 82801, United States

Location

Rambam Medical Center

Haifa, 31096, Israel

Location

Instituto Nacional de Enfermedades Neoplasicas

Lima, Lima 34, Peru

Location

Related Links

MeSH Terms

Conditions

Leukemia, Megakaryoblastic, AcuteLeukemia, Monocytic, AcuteLeukemia, Myelomonocytic, AcuteLeukemia, Myeloid, AcuteLeukemia, Erythroblastic, AcuteAnemia, Refractory, with Excess of Blasts

Interventions

Watchful WaitingObservationtipifarnib

Condition Hierarchy (Ancestors)

Leukemia, MyeloidLeukemiaNeoplasms by Histologic TypeNeoplasmsHematologic DiseasesHemic and Lymphatic DiseasesMyeloproliferative DisordersBone Marrow DiseasesAnemia, RefractoryAnemiaMyelodysplastic Syndromes

Intervention Hierarchy (Ancestors)

Outcome Assessment, Health CareOutcome and Process Assessment, Health CareQuality of Health CareHealth Services AdministrationMethodsInvestigative Techniques

Results Point of Contact

Title
Study statistician
Organization
ECOG-ACRIN Statistical Office

Study Officials

  • Selina Luger

    ECOG-ACRIN Cancer Research Group

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
LTE60
Restrictive Agreement
Yes

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
NIH
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 6, 2004

First Posted

October 8, 2004

Study Start

August 18, 2004

Primary Completion

February 20, 2015

Last Updated

March 20, 2024

Results First Posted

November 10, 2015

Record last verified: 2024-03

Locations