Success Metrics

Clinical Success Rate
90.6%

Based on 58 completed trials

Completion Rate
91%(58/64)
Active Trials
3(4%)
Results Posted
33%(19 trials)
Terminated
6(8%)

Phase Distribution

Ph phase_3
1
1%
Ph phase_1
31
44%
Ph phase_2
38
54%

Phase Distribution

31

Early Stage

38

Mid Stage

1

Late Stage

Phase Distribution70 total trials
Phase 1Safety & dosage
31(44.3%)
Phase 2Efficacy & side effects
38(54.3%)
Phase 3Large-scale testing
1(1.4%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

87.9%

58 of 66 finished

Non-Completion Rate

12.1%

8 ended early

Currently Active

3

trials recruiting

Total Trials

71

all time

Status Distribution
Active(3)
Completed(58)
Terminated(8)
Other(2)

Detailed Status

Completed58
Terminated6
unknown2
Active, not recruiting2
Withdrawn2
Recruiting1

Development Timeline

Analytics

Development Status

Total Trials
71
Active
3
Success Rate
90.6%
Most Advanced
Phase 3

Trials by Phase

Phase 131 (44.3%)
Phase 238 (54.3%)
Phase 31 (1.4%)

Trials by Status

recruiting11%
unknown23%
completed5882%
active_not_recruiting23%
terminated68%
withdrawn23%

Recent Activity

Clinical Trials (71)

Showing 20 of 71 trialsScroll for more
NCT03155620Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

Active Not Recruiting
NCT04284774Phase 2

Tipifarnib for the Treatment of Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With HRAS Gene Alterations, a Pediatric MATCH Treatment Trial

Active Not Recruiting
NCT06540963Phase 2

Tipifarnib and Naxitamab for Relapsed/Refractory Neuroblastoma

Recruiting
NCT04997902Phase 1

Combination Trial of Tipifarnib and Alpelisib in Adult Recurrent/ Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC)

Completed
NCT04809233

Expanded Access to Tipifarnib

Unknown
NCT03496766Phase 2

Tipifarnib in Advanced Squamous NSCLC With Oncogen HRAS MutAtionS

Terminated
NCT02779777Phase 2

Tipifarnib in Subjects With Myelodysplastic Syndromes

Terminated
NCT02807272Phase 2

Tipifarnib in Subjects With Chronic Myelomonocytic Leukemia, Other MDS/MPN, and Acute Myeloid Leukemia

Completed
NCT02383927Phase 2

Phase II Study of Tipifarnib in Squamous Head and Neck Cancer With HRAS Mutations

Completed
NCT02464228Phase 2

Investigation of Tipifarnib in Treatment of Subjects With Peripheral T-Cell Lymphoma (PTCL) That Have Not Responded to Standard Therapy

Completed
NCT03719690Phase 2

Safety and Efficacy of Tipifarnib in Head and Neck Cancer With HRAS Mutations and Impact of HRAS on Response to Therapy

Completed
NCT00093470Phase 3

Tipifarnib in Treating Patients With Acute Myeloid Leukemia in Remission

Completed
NCT04865159Phase 1

Cardiovascular Safety Study of Tipifarnib in Patients With Advanced Solid Malignancies

Terminated
NCT05693090Phase 1

Tipifarnib and Osimertinib in EGFR-mutated Non-Small Cell Lung Cancer

Withdrawn
NCT02535650Phase 2

Study of Tipifarnib in Patients With Previously-Treated, Advanced, HRAS Mutant Urothelial Carcinoma

Unknown
NCT00470301Phase 1

Tipifarnib and Combination Chemotherapy in Treating Patients With Stage II or Stage III Breast Cancer

Completed
NCT00026104Phase 2

Combination Chemotherapy Plus Radiation Therapy With or Without Tipifarnib in Treating Patients With Locally Advanced Pancreatic Cancer

Completed
NCT00077519Phase 1

Tipifarnib and Radiation Therapy in Treating Patients With Unresectable Locally Advanced Pancreatic Cancer

Completed
NCT00082888Phase 2

Tipifarnib in Treating Patients With Relapsed or Refractory Lymphoma

Completed
NCT00004009Phase 1

R115777 in Treating Patients With Refractory or Recurrent Acute Leukemia or Chronic Myelogenous Leukemia

Completed

Drug Details

Intervention Type
DRUG
Total Trials
71