Fluorouracil, External-Beam Radiation Therapy, and Gemcitabine With or Without Brachytherapy Using Phosphorus P32 in Treating Patients With Locally or Regionally Advanced Unresectable Adenocarcinoma of the Pancreas

NCT00079365 | Unknown

• 2 other identifiers: CDR0000355400USFPG-6034
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

RATIONALE: Drugs used in chemotherapy, such as fluorouracil and gemcitabine, work in different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Fluorouracil may make the tumor cells more sensitive to radiation therapy. Brachytherapy uses radioactive material, such as phosphorus P32, placed directly into or near a tumor to kill tumor cells. Combining chemotherapy and external-beam radiation therapy with brachytherapy may kill more tumor cells. PURPOSE: This randomized clinical trial is studying fluorouracil, gemcitabine, external-beam radiation therapy, and brachytherapy using phosphorus P32 to see how well they work compared to fluorouracil, gemcitabine, and external-beam radiation therapy in treating patients with locally or regionally advanced unresectable adenocarcinoma of the pancreas (pancreatic cancer).

Conditions

Pancreatic Cancer

Keywords

adenocarcinoma of the pancreas; stage II pancreatic cancer; stage III pancreatic cancer; stage IV pancreatic cancer

Interventions

fluorouracil DRUG

gemcitabine hydrochloride DRUG

brachytherapy RADIATION

phosphorus P32 RADIATION

radiation therapy RADIATION

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

DISEASE CHARACTERISTICS: * Histologically or cytologically confirmed pancreatic adenocarcinoma * Locally or regionally advanced disease * Unresectable disease defined by the following: * Invasion into a major vascular structure determined preoperatively by a CT scan, angiogram, or CT portogram or intraoperatively by surgeon * Severe comorbidities precluding operation, such as congestive heart failure, coronary artery disease, or chronic obstructive pulmonary disease * Bidimensionally measurable disease by CT scan * No recurrent disease * No previously resected pancreatic cancer * No tumors of the pancreas not ductal in origin (e.g., islet cell tumors, lymphoma, or sarcoma) PATIENT CHARACTERISTICS: Age * 18 and over Performance status * Karnofsky 60-100% Life expectancy * Not specified Hematopoietic * Absolute neutrophil count: ≥ 1,500/mm\^3 * Platelet count ≥ 50,000/mm\^3 * Hemoglobin ≥ 10 g/dL Hepatic * Bilirubin \< 2 times upper limit of normal (ULN) * AST and ALT \< 5 times ULN * Alkaline phosphatase \< 5 times ULN * Albumin ≥ 2.5 mg/dL Renal * Creatinine ≤ 1.5 mg/dL Cardiovascular * See Disease Characteristics Pulmonary * See Disease Characteristics Other * No other malignancy within the past 5 years except curatively resected basal cell carcinoma of the skin, carcinoma in situ of the cervix or breast, or early stage prostate cancer * Not pregnant or nursing * Negative pregnancy test * Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy * Not specified Chemotherapy * Not specified Endocrine therapy * Not specified Radiotherapy * No prior radiotherapy for pancreatic adenocarcinoma Surgery * See Disease Characteristics Other * No prior chromic phosphate P32 suspension (Phosphocol®) * At least 4 weeks since prior cytotoxic therapy for pancreatic adenocarcinoma * At least 4 weeks since prior investigational anti-tumoral agents * No other concurrent investigational agents * No other concurrent anticancer agents

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• University of South Florida: lead

Study Sites (1)

USF Physician's Group

Tampa, Florida, 33606, United States

Location

MeSH Terms

Conditions

Pancreatic Neoplasms

Interventions

Fluorouracil; Gemcitabine; Brachytherapy; Phosphorus-32; Radiotherapy

Condition Hierarchy (Ancestors)

Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Endocrine Gland Neoplasms; Digestive System Diseases; Pancreatic Diseases; Endocrine System Diseases

Intervention Hierarchy (Ancestors)

Uracil; Pyrimidinones; Pyrimidines; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds; Deoxycytidine; Cytidine; Pyrimidine Nucleosides; Therapeutics

Study Officials

• Alexander Rosemurgy, MD

  University of South Florida

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Purpose: TREATMENT
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: March 8, 2004
• First Posted: March 10, 2004
• Study Start: May 1, 2001
• Last Updated: December 4, 2013

Record last verified: 2005-05

Locations

US (1)