NCT00076739

Brief Summary

This study will use magnetic resonance imaging (MRI) to examine which areas of the brain are involved in performing certain cognitive tasks. MRI uses a strong magnetic field and radio waves to produce images of body tissues and organs that provide information about structure and function of tissues. Healthy normal volunteers between 21 and 40 years of age may be eligible for this study. Candidates must be native English speakers and must be right-handed. They must have no history of nervous system disease or psychiatric disorder. Candidates are screened with questionnaires and a neurological examination. Participants undergo functional MRI scanning. For this procedure, the subject lies on a stretcher that moves into the scanner - a metal cylinder surrounded by a strong magnetic field. During the scan, he or she is asked to make various decisions about whether words are related or not. Two words are presented visually, separated by a variable time delay. The subject reads both words, decides as quickly and accurately as possible whether the two words are related or not, and indicates the answer by pressing a button. The test takes about 2 hours. When it is completed, the subject completes a written questionnaire concerning his or her experience in the scanner. ...

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
452

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Feb 2004

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 2, 2004

Completed
Same day until next milestone

Study Start

First participant enrolled

February 2, 2004

Completed
1 day until next milestone

First Posted

Study publicly available on registry

February 3, 2004

Completed
7.9 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 12, 2011

Completed
Last Updated

July 2, 2017

Status Verified

December 12, 2011

First QC Date

February 2, 2004

Last Update Submit

June 30, 2017

Conditions

Healthy

Keywords

Prefrontal CortexSemantic MemorySemantic RelationsPriming ParadigmfMRIHealthy VolunteerHV

Eligibility Criteria

Age21 Years - 40 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • In all the studies, subjects will consist of healthy, native English-speaking, right-handed volunteers, as measured by the Edinburgh Handedness Inventory.
  • Subjects will range in age from 21 to 40 years old and they will be included regardless of race or gender.

You may not qualify if:

  • Non-native English speakers and non-right handers will be excluded as mentioned above, as will non-neurologically normal volunteers.
  • Subjects younger than 21 and older than 40 will be excluded.
  • A pregnancy test will be employed with all women of childbearing age. The results must be negative in order to proceed with the MRI.
  • Subjects with any of the following: aneurysm clip; implanted neural stimulator; implanted cardiac pacemaker or auto-defibrillator; cochlear implant; ocular foreign body, e.g. metal shavings; permanent eyeliner; insulin pump; or irremovable body piercing will be excluded from the study due to the possible dangerous effects of the magnet upon metal objects in the body.
  • Subjects taking central nervous system active medications will be excluded.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

  • Abernethy M, Coney J. Semantic category priming in the left cerebral hemisphere. Neuropsychologia. 1996 May;34(5):339-50. doi: 10.1016/0028-3932(95)00144-1.

    PMID: 9148190BACKGROUND

  • Belliveau JW, Kennedy DN Jr, McKinstry RC, Buchbinder BR, Weisskoff RM, Cohen MS, Vevea JM, Brady TJ, Rosen BR. Functional mapping of the human visual cortex by magnetic resonance imaging. Science. 1991 Nov 1;254(5032):716-9. doi: 10.1126/science.1948051.

    PMID: 1948051BACKGROUND

  • Belliveau JW, Rosen BR, Kantor HL, Rzedzian RR, Kennedy DN, McKinstry RC, Vevea JM, Cohen MS, Pykett IL, Brady TJ. Functional cerebral imaging by susceptibility-contrast NMR. Magn Reson Med. 1990 Jun;14(3):538-46. doi: 10.1002/mrm.1910140311.

    PMID: 2355835BACKGROUND

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

February 2, 2004

First Posted

February 3, 2004

Study Start

February 2, 2004

Study Completion

December 12, 2011

Last Updated

July 2, 2017

Record last verified: 2011-12-12

Locations

US(1)