Magnetic Resonance Imaging of the Brain in Emotional Processing

NCT00061204 | Completed

• 2 other identifiers: 03019503-N-0195
• Study Type: observational
• Target: 38
• Locations: 1 country
• Sites: 1

Brief Summary

This study will use magnetic resonance imaging (MRI) to identify brain regions involved in performing certain tasks, especially those involving emotions. MRI is a diagnostic tool that uses a strong magnetic field and radio waves to produce images of structural and chemical changes in the brain. The study will also examine which MRI techniques are best to use when scanning brain areas involved in different emotions. Healthy normal volunteers between 18 and 40 years of age who are right-handed and are native English speakers may be eligible for this study. Individuals with a history of neurological disease, post-traumatic stress disorder or other psychiatric disorder, or who have a history of physical or sexual abuse may not participate. Candidates will be screened with a written questionnaire and a medical history, including psychiatric and neurological information. Participants will perform tasks involving emotions while undergoing MRI scanning. For this procedure, the subject lies on a table in a narrow metal cylinder (the scanner) containing a magnetic field. Scanning time varies from 20 minutes to 3 hours, with most scans lasting between 45 and 90 minutes. The subject is asked to lie still for up to 10 minutes at a time. During the scan, the subject performs simple tasks involving the viewing of pictures on a screen. Other tasks involve viewing pictures and responding to them by pressing buttons. Some pictures are violent or pornographic, while others are pleasant to view. Of a total of 162 pictures, 30 percent are categorized as graphic and possibly disturbing.

Conditions

Healthy

Keywords

fMRI; Susceptibility Artifacts; Prefrontal Cortex; Temporal Lobes; Methodology; Healthy Volunteer; HV

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• The study population will consist of young healthy volunteers.
• Age range: 18 to 40
• Right-handedness (some left-handed subjects may be recruited for preliminary behavioral studies)

You may not qualify if:

• Individuals with a neurological or psychiatric history or medical condition that would compromise our interpretation of the fMRI results will be excluded.
• Individuals with a current or past history of post-traumatic stress disorder or other psychiatric disorder or individuals with a history of physical or sexual abuse will be excluded as they may be disturbed by viewing graphic pictures.
• Subjects with contraindications to exposure to high magnetic field.

Sponsors & Collaborators

• National Institute of Neurological Disorders and Stroke (NINDS): lead

Study Sites (1)

National Institute of Neurological Disorders and Stroke (NINDS)

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Belliveau JW, Kennedy DN Jr, McKinstry RC, Buchbinder BR, Weisskoff RM, Cohen MS, Vevea JM, Brady TJ, Rosen BR. Functional mapping of the human visual cortex by magnetic resonance imaging. Science. 1991 Nov 1;254(5032):716-9. doi: 10.1126/science.1948051.

  PMID: 1948051 BACKGROUND

• Belliveau JW, Rosen BR, Kantor HL, Rzedzian RR, Kennedy DN, McKinstry RC, Vevea JM, Cohen MS, Pykett IL, Brady TJ. Functional cerebral imaging by susceptibility-contrast NMR. Magn Reson Med. 1990 Jun;14(3):538-46. doi: 10.1002/mrm.1910140311.

  PMID: 2355835 BACKGROUND

• Bodner M, Kroger J, Fuster JM. Auditory memory cells in dorsolateral prefrontal cortex. Neuroreport. 1996 Aug 12;7(12):1905-8. doi: 10.1097/00001756-199608120-00006.

  PMID: 8905689 BACKGROUND

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: May 21, 2003
• First Posted: May 22, 2003
• Study Start: May 1, 2003
• Study Completion: April 1, 2006
• Last Updated: March 4, 2008

Record last verified: 2006-04

Locations

US (1)