Rhythm Perception and Generation

NCT00080067 | Completed

• 2 other identifiers: 04014604-N-0146
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

This study will examine how different brain areas are involved in the perception of rhythmic patterns and the performance of rhythmic movements. Patients with certain types of brain diseases, such as Parkinson's disease and some types of stroke, may have difficulty performing rhythmic movements, such as finger tapping. Healthy, right-handed volunteers between 21 and 65 years of age may be eligible for this study. Candidates with visual, motor or hearing problems are excluded, as are musicians and pregnant women. Participants will come to the National Institutes of Health (NIH) Clinical Center for up to six sessions of functional magnetic resonance imaging (fMRI) scanning. MRI uses a strong magnetic field and radio waves to obtain images of body organs and tissues. The scanner is a metal cylinder surrounded by a magnetic field. During the MRI, the subject lies still for up to 20 minutes at a time on a table in the cylinder and wears earplugs to muffle loud knocking noises that occur with the electrical switching of the magnetic fields. He or she can communicate with the MRI staff through a microphone at all times during the procedure. For fMRI, images are obtained while the subject performs a task, such as hearing sounds or moving a finger. The machine detects changes in brain movement that are involved in performing the task. The tasks are explained, and subjects can practice them before entering the scanner.

Conditions

Healthy

Keywords

Movement; Anticipation; Stimulation; Timing; Execution; Perception; Rhythm; Healthy Volunteer; HV

Eligibility Criteria

• Age: 21 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Fifty healthy, right-handed adult (aged between 21 to 65 years old) volunteers will be recruited from people who are registered as HMCS normal volunteers. All subjects participating in MR studies should have a valid Clinical Center Medical Record Number.
• Female subjects of childbearing potential will have a pregnancy test and a specific interview prior to the study to ensure that pregnant subjects will not participate in the study.

You may not qualify if:

• Subjects with implanted devices such as pacemakers, medication pumps or defibrillators, metal in the cranium except mouth, intracardiac lines, history of shrapnel injury or any other condition/device that may be contraindicated or prevent the acquisition of MRI.
• Pregnant female. A pregnancy test will be performed within 24 hours preceding each MRI and if the result is positive, that subject will not be studied.
• Subjects with claustrophobia
• Subjects with any visual, motor or hearing difficulties
• Musicians

Sponsors & Collaborators

• National Institute of Neurological Disorders and Stroke (NINDS): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Artieda J, Pastor MA, Lacruz F, Obeso JA. Temporal discrimination is abnormal in Parkinson's disease. Brain. 1992 Feb;115 Pt 1:199-210. doi: 10.1093/brain/115.1.199.

  PMID: 1559154 BACKGROUND

• Aschersleben G. Temporal control of movements in sensorimotor synchronization. Brain Cogn. 2002 Feb;48(1):66-79. doi: 10.1006/brcg.2001.1304.

  PMID: 11812033 BACKGROUND

• Asanuma H, Keller A. Neuronal mechanisms of motor learning in mammals. Neuroreport. 1991 May;2(5):217-24. doi: 10.1097/00001756-199105000-00001.

  PMID: 1912451 BACKGROUND

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: March 23, 2004
• First Posted: March 23, 2004
• Study Start: March 22, 2004
• Study Completion: February 23, 2009
• Last Updated: July 2, 2017

Record last verified: 2009-02-23

Locations

US (1)