NCT00057616

Brief Summary

Subjects are randomized to one of two treatment arms. All subjects are screened for eligibility within 28 days prior to randomization. The study consists of a treatment phase and a follow-up phase. Subjects are treated in repeating 4 week cycles.

Trial Health

93
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
274

participants targeted

Target at P50-P75 for phase_3

Timeline
Completed

Started Oct 2002

Typical duration for phase_3

Geographic Reach
9 countries

49 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2002

Completed
6 months until next milestone

First Submitted

Initial submission to the registry

April 4, 2003

Completed
3 days until next milestone

First Posted

Study publicly available on registry

April 7, 2003

Completed
2.3 years until next milestone

Study Completion

Last participant's last visit for all outcomes

July 15, 2005

Completed
Last Updated

November 8, 2019

Status Verified

November 1, 2019

First QC Date

April 4, 2003

Last Update Submit

November 6, 2019

Conditions

Keywords

Metastatic MelanomaMelanomaRevimidCC5013

Interventions

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
* Understand and voluntarily sign an informed consent form * Able to adhere to the study visit schedule and other protocol requirements * Metastatic malignant melanoma now stage IV, relapsed or refractory to standard metastatic therapy * Women of childbearing potential must have a negative serum or urine pregnancy test within 7 days of starting study drug * Patients with active brain disease, or newly diagnosed brain metastases, within 4 weeks prior to the start of study treatment are excluded.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (49)

The Canberra Hospital

Garran, Australian Capital Territory, 2605, Australia

Location

Royal Prince Alfred Hospital

Camperdown, New South Wales, 2050, Australia

Location

Sydney Cancer Centre

Camperdown, New South Wales, 2145, Australia

Location

Royal Newcastle Hospital

Newcastle, New South Wales, 2300, Australia

Location

Westmead Hospital

Westmead, New South Wales, 2145, Australia

Location

Roayl Brisbane Hospital

Herston, Queensland, 4029, Australia

Location

Princess Alexandra Hospital

Woolloongabba, Queensland, 4102, Australia

Location

Royal Adelaide Hospital

Adelaide, South Australia, 5000, Australia

Location

Royal Hobart Hospital

Hobart, Tasmania, 7001, Australia

Location

Cabrini Hospital

Malvern, Victoria, 3144, Australia

Location

Sir Charles Gairdner Hospital

Nedlands, Western Australia, 6009, Australia

Location

Mount HospitalOncology

Perth, Western Australia, 6009, Australia

Location

North-Estonian Regional Hospital

Tallinn, 11619, Estonia

Location

Tartu University Clinics Onkology & Haematology Clinic

Tartu, 51003, Estonia

Location

Klinick fur Dermatologie

Berlin, D-10117, Germany

Location

Dermatologie Klinik der Ruhr Universitat Bochum- St. Joseph's Hospital

Bochum, 44791, Germany

Location

Klinick fur Dermatolgie

Bonn, 53105, Germany

Location

Universitatsklinikum Freiburg

Freiburg im Breisgau, 79104, Germany

Location

Universitatsklinik Eppendorf

Hamburg, D-20246, Germany

Location

Kinkum der Christian-Albrecht-Universitat KielDepartment of Dermatologie

Kiel, D-24105, Germany

Location

Klinik fur DermatologieVenerologie und Allergologie

Mannheim, D-68135, Germany

Location

Latvian Onkology Centre

Riga, LV-1079, Latvia

Location

Klaipeda Hospital

Klaipėda, LT-5808, Lithuania

Location

Vilnius University Onkology Institute

Vilnius, LT-2600, Lithuania

Location

Daniel DenHoed Kliniek

Rotterdam, Netherlands

Location

Panorama Medi-Clinic / Panorama Oncology Unit

Cape Town, 7506, South Africa

Location

Addington Hospital

Durban, 4001, South Africa

Location

Wilgers Hospital / Wilgers Oncology Centre

Hatfield, Pretoria, 0028, South Africa

Location

Sandton Oncology Centre

Morningside, Johannesburg, South Africa

Location

St. Georges Hospital

Port Elizabeth, 6001, South Africa

Location

Little Company of Mary / Mary Potter Oncology Centre

Pretoria, 0002, South Africa

Location

Pretoria Academic Hospital / Department Medical Oncology

Pretoria, South Africa

Location

Durban Oncology Centre

Westridge, Durban, 4001, South Africa

Location

Dnipropetrovsk State Medical Academy

Dnipropetrovsk, Ukraine

Location

Kharkov Postgraduate Medical Academy, Kharkov Regional Clinical Oncology Center

Kharkiv, 61070, Ukraine

Location

Scientific Research Institute of OncologySoft Tissue Department

Kiev, 03022, Ukraine

Location

Kiev City Oncology Hospital

Kiev, 3115, Ukraine

Location

Lviv State Medical University Regional Oncology Centre

Lviv, 79010, Ukraine

Location

Odessa Regional Oncology DispensaryChemotherapy Dept

Odesa, 65055, Ukraine

Location

Uzhgorod Regional Oncology Diepensary

Uzhhorod, 88000, Ukraine

Location

Cancer Centre

Egbaston, Birmingham, B15 2TH, United Kingdom

Location

Christies Hospital

Withington, Manchester, M2O 4BX, United Kingdom

Location

Beatson Oncology CentreWestern InfirmaryOncology

Glasgow, G11 6NT, United Kingdom

Location

Cancer Research BldgDivsion of Cancer Medicine Research

Leeds, LS9 7TF, United Kingdom

Location

Roayl Free Hospital

London, NW3 2QG, United Kingdom

Location

St. George's Hospital

London, SW17 0QT, United Kingdom

Location

Royal Marsden Hospital Department of Oncology

London, SW3 6JJ, United Kingdom

Location

Royal Marsden Hospital

London, United Kingdom

Location

Newcastle GeneralOncology

Newcastle, NE4 6BE, United Kingdom

Location

Related Publications (1)

  • Eisen T, Trefzer U, Hamilton A, Hersey P, Millward M, Knight RD, Jungnelius JU, Glaspy J. Results of a multicenter, randomized, double-blind phase 2/3 study of lenalidomide in the treatment of pretreated relapsed or refractory metastatic malignant melanoma. Cancer. 2010 Jan 1;116(1):146-54. doi: 10.1002/cncr.24686.

    PMID: 19862820BACKGROUND

MeSH Terms

Conditions

MelanomaNeoplasm Metastasis

Interventions

Lenalidomide

Condition Hierarchy (Ancestors)

Neuroendocrine TumorsNeuroectodermal TumorsNeoplasms, Germ Cell and EmbryonalNeoplasms by Histologic TypeNeoplasmsNeoplasms, Nerve TissueNevi and MelanomasSkin NeoplasmsNeoplasms by SiteSkin DiseasesSkin and Connective Tissue DiseasesNeoplastic ProcessesPathologic ProcessesPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

PhthalimidesPhthalic AcidsAcids, CarbocyclicCarboxylic AcidsOrganic ChemicalsPiperidonesPiperidinesHeterocyclic Compounds, 1-RingHeterocyclic CompoundsIsoindolesHeterocyclic Compounds, 2-RingHeterocyclic Compounds, Fused-Ring

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
DOUBLE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 4, 2003

First Posted

April 7, 2003

Study Start

October 1, 2002

Study Completion

July 15, 2005

Last Updated

November 8, 2019

Record last verified: 2019-11

Locations