NCT00037440

Brief Summary

To extend knowledge of the genetic factors affecting the course of cardiovascular disease risk factor development over a substantial portion of an individual's lifetime.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,735

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Sep 2001

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2001

Completed
9 months until next milestone

First Submitted

Initial submission to the registry

May 16, 2002

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 17, 2002

Completed
3.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2005

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2005

Completed
Last Updated

December 3, 2014

Status Verified

December 1, 2014

Enrollment Period

3.9 years

First QC Date

May 16, 2002

Last Update Submit

December 1, 2014

Conditions

Cardiovascular DiseasesHeart Diseases

Outcome Measures

Primary Outcomes (1)

  • Plasma lipid levels

    Change from 8 - 18 years of age

Study Arms (2)

BHS Whites

Whites from Bogalusa, Louisiana; initially recruited as schoolchildren and followed at irregular intervals (about 3 years apart on average) into adolescence and early adulthood. There were no interventions of any kind-- this was an observational study only.

Genetic: Polymorphisms measured

BHS African Americans

African Americans from Bogalusa, Louisiana, initially recruited as schoolchildren and followed at irregular intervals (about 3 years apart on average) into adolescence and early adulthood. There were no interventions of any kind-- this was an observational study only.

Genetic: Polymorphisms measured

Interventions

Polymorphisms measuredGENETIC
BHS African AmericansBHS Whites

Eligibility Criteria

Age8 Years - 38 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64)
Sampling MethodNon-Probability Sample
Study Population

Community study of schoolchildren in Bogalusa, Louisiana, with follow-up into young adulthood. Both whites and African Americans recruited.

Schoolchildren from Bogalusa, Louisiana. All children in Bogalusa public schools were eligible.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (1)

  • Hallman DM, Srinivasan SR, Chen W, Boerwinkle E, Berenson GS. The beta(2)-adrenergic receptor Arg16-gly polymorphism and interactions involving beta(2)- and beta(3)-adrenergic receptor polymorphisms are associated with variations in longitudinal serum lipid profiles: the Bogalusa Heart Study. Metabolism. 2004 Sep;53(9):1184-91. doi: 10.1016/j.metabol.2004.03.019.

    PMID: 15334382BACKGROUND

MeSH Terms

Conditions

Cardiovascular DiseasesHeart Diseases

Study Officials

  • David Hallman

    The University of Texas Health Science Center, Houston

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
ECOLOGIC OR COMMUNITY
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor, Epidemiology and Disease Control

Study Record Dates

First Submitted

May 16, 2002

First Posted

May 17, 2002

Study Start

September 1, 2001

Primary Completion

August 1, 2005

Study Completion

August 1, 2005

Last Updated

December 3, 2014

Record last verified: 2014-12