NCT00217828

Brief Summary

To evaluate the therapeutic effects of the serotonergic agent, citalopram, on hostility and other behavioral risk factors, and biological markers of disease risk (serum lipids, insulin and glucose; autonomic balance and stress-related cardiovascular reactivity; platelet activation).

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Mar 2002

Shorter than P25 for not_applicable cardiovascular-diseases

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2002

Completed
11 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2003

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2003

Completed
2.6 years until next milestone

First Submitted

Initial submission to the registry

September 19, 2005

Completed
3 days until next milestone

First Posted

Study publicly available on registry

September 22, 2005

Completed
Last Updated

June 11, 2014

Status Verified

June 1, 2014

Enrollment Period

11 months

First QC Date

September 19, 2005

Last Update Submit

June 10, 2014

Conditions

Cardiovascular DiseasesHeart Diseases

Interventions

citalopramDRUG

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (2)

  • Rice E, Vize C, Manuck S, Kamarck T. Mood reactivity to daily social conflict in hostile adults: An experimental intervention. Health Psychol. 2025 May;44(5):436-445. doi: 10.1037/hea0001411.

    PMID: 40232779DERIVED

  • Kamarck TW, Muldoon MF, Manuck SB, Haskett RF, Cheong J, Flory JD, Vella E. Citalopram improves metabolic risk factors among high hostile adults: results of a placebo-controlled intervention. Psychoneuroendocrinology. 2011 Aug;36(7):1070-9. doi: 10.1016/j.psyneuen.2011.01.005. Epub 2011 Feb 8.

    PMID: 21306829DERIVED

MeSH Terms

Conditions

Cardiovascular DiseasesHeart Diseases

Interventions

Citalopram

Intervention Hierarchy (Ancestors)

PropylaminesAminesOrganic ChemicalsNitrilesBenzofuransHeterocyclic Compounds, 2-RingHeterocyclic Compounds, Fused-RingHeterocyclic Compounds

Study Officials

  • Thomas Kamarck (subproject PI)

    University of Pittsburgh

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Purpose
TREATMENT
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 19, 2005

First Posted

September 22, 2005

Study Start

March 1, 2002

Primary Completion

February 1, 2003

Study Completion

February 1, 2003

Last Updated

June 11, 2014

Record last verified: 2014-06