Imatinib Mesylate in Treating Patients With Advanced Cancer and Kidney Failure

NCT00026169 | Completed Phase 1

• 8 other identifiers: NCI-2012-03115CWRU 1Y01U01CA062487U01CA062505U01CA069853U01CA062502U01CA062491U01CA099168
• Study Type: interventional
• Target: 69
• Locations: 1 country
• Sites: 1

Brief Summary

Phase I trial to determine the dose of imatinib mesylate that is most effective with the least amount of toxic side effects in treating patients who have advanced cancer and kidney failure. Imatinib mesylate may stop the growth of cancer cells by stopping the enzyme necessary for cancer cell growth. Kidney failure may delay the elimination of imatinib mesylate from the body, which may lead to longer drug exposure and increase toxic side effects

Conditions

Malignant Neoplasm; Unspecified Adult Solid Tumor, Protocol Specific

Outcome Measures

Primary Outcomes (1)

• Maximum tolerated dose (MTD) of imatinib mesylate, based on the National Cancer Institute Common Toxicity Criteria (NCI CTC) v2.0

  Toxicities will be tabulated and summarized by organ systems.

  Up to 4 weeks

Secondary Outcomes (3)

• Estimates of incidences of adverse events and dose limiting toxicity (DLT), based on the NCI CTC v2.0

  Up to 7 years

• Pharmacokinetic parameters

  Up to day 16

• Response rates based on the Response Evaluation Criteria in Solid Tumors

  Up to 7 years

Study Arms (1)

Treatment (imatinib mesylate)

EXPERIMENTAL

Patients receive oral imatinib mesylate once or twice daily on days 1 and 4-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. Cohorts of 3-6 patients in each stratum receive escalating doses of imatinib mesylate until the MTD is determined. The MTD is defined as the dose preceding that at which at least 2 of 3 or 2 of 6 patients experience dose-limiting toxicity.

Drug: imatinib mesylate; Other: laboratory biomarker analysis; Other: pharmacological study

Interventions

imatinib mesylate DRUG

Given orally

Also known as: CGP 57148, Gleevec, Glivec

Treatment (imatinib mesylate)

laboratory biomarker analysis OTHER

Correlative studies

Treatment (imatinib mesylate)

pharmacological study OTHER

Correlative studies

Also known as: pharmacological studies

Treatment (imatinib mesylate)

Eligibility Criteria

• Age: 16 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients must have histologically or cytologically confirmed malignancy, which is metastatic or unresectable and for which standard curative or palliative measures do not exist or are no longer effective; the following tumor types are eligible:
• (Note: All patients with normal renal function should be referred first to higher priority national trials under cooperative group or Novartis sponsorship; these studies include the Intergroup S0033 trial in GIST tumors and NABTC-9908 trial for gliomas; Novartis is also sponsoring ongoing clinical trials in pediatric patients with Philadelphia chromosome - positive acute lymphocytic leukemia and chronic myelogenous leukemia; for complete listing of other trials and sites collaborating investigators are encouraged to verify status of current national trials on the NCI - Physician Data Query \[PDQ\] system)
• Patients with all hematological malignancies are eligible (such as myeloma, leukemia and lymphoma patients) provided the patient(s) have exhausted curative intent or life prolonging therapy and meet other eligibility in terms of blood counts; patients with Philadelphia chromosome - positive leukemia should be enrolled on other NCI or Novartis sponsored trials, if possible
• Any solid tumor patient with abnormal renal dysfunction and including 12 patients with normal renal function (controls for pharmacokinetics) with an emphasis on patients with gastrointestinal stromal tumors (GIST) and including patients with glioma; patients with glioma who require corticosteroids or anticonvulsants must be on a stable dose of corticosteroids and seizure free for one month prior to enrollment
• (Note: Slots will be retained for patients with CML or other Philadelphia chromosome-positive leukemia or GIST tumors beyond the initial dose level cohorts, since these tumor types have greater potential to respond to therapy); every effort should be made to enroll patients with glioma or GIST on available cooperative group trials first
• Prior chemotherapy, radiation therapy, hormonal therapy and immunotherapy are allowed, including prior therapy with STI571; there is no ceiling on number of prior regimens
• ECOG performance status =\< 2, (Karnofsky \>= 60%) and a life expectancy of at least 3 months
• Leukocytes \>= 3,000/uL, OR
• Absolute neutrophil count \>= 1,500/uL
• Platelets \>= 100,000/uL
• Total bilirubin within normal institutional limits
• AST (SGOT)/ALT (SGPT) =\< 1.5 times the institutional upper limit of normal
• Patients with abnormal kidney function will be allowed and will be grouped accordingly
• Patients with gliomas and brain metastases, who require corticosteroids or anticonvulsants must be on a stable dose of corticosteroids and seizure free for one month prior to enrollment; patients with brain metastasis should have had brain irradiation
• The effects of STI571 on the developing human fetus at the recommended therapeutic dose are unknown; for this reason and because STI571 is known to be teratogenic, women of childbearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control) prior to study entry and for the duration of study participation; since interaction with STI571 and oral contraceptives is possible, a barrier method should be used and oral contraceptives should not be the only method; a negative pregnancy test is required prior to starting therapy for women of child bearing age; should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately

You may not qualify if:

• Patients who have had chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to study enrollment (excluding hydroxyurea if hydroxyurea was administered to patients with leukemia to maintain a lower WBC count); in the case of leukemic patients on maintenance hydroxyurea, patients may not receive hydroxyurea within 24 hours prior to initiation of therapy
• Patients undergoing therapy with other investigational agents; patients on therapeutic doses of warfarin are excluded
• Patients who have had liver, kidney, lung transplants or taking FK-506, cyclosporine as an immunosuppressive agent; these agents may cause increased toxicity with STI571
• Uncontrolled intercurrent illness including but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
• Pregnant and nursing women are excluded from this study because STI571 is an agent with the potential for teratogenic or abortifacient effects; because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with STI571, breastfeeding should be discontinued if the mother is treated with STI571
• Because patients with immune deficiency are at increased risk of lethal infections, when treated with marrow-suppressive therapy, HIV-positive patients receiving combination anti-retroviral therapy are excluded from the study because of possible pharmacokinetic interactions with STI571
• Patients receiving renal dialysis treatments while on the study will be enrolled in two cohorts per the schema
• Patients must not have had a major surgery (e.g., thoracotomy, intra-abdominal surgery) within 14 days prior to registration
• Patients with unstable or untreated (irradiated) brain metastases should be excluded

Sponsors & Collaborators

• National Cancer Institute (NCI): lead

Study Sites (1)

Case Western Reserve University

Cleveland, Ohio, 44106, United States

Location

MeSH Terms

Conditions

Neoplasms

Interventions

Imatinib Mesylate

Intervention Hierarchy (Ancestors)

Benzamides; Amides; Organic Chemicals; Benzoates; Acids, Carbocyclic; Carboxylic Acids; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons; Piperazines; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds; Pyrimidines

Study Officials

• Afshin Dowlati

  Case Western Reserve University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 9, 2001
• First Posted: January 27, 2003
• Study Start: September 1, 2001
• Primary Completion: April 1, 2005
• Last Updated: January 10, 2013

Record last verified: 2013-01

Locations

US (1)