NCT00025701|Completed
EEG and EMG Studies of Hand Dystonia
EEG Study of Movement-Related Center-Surround Organization in Hand Dystonia
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EEG Study of Movement-Related Center-Surround Organization in Hand Dystonia
Sponsor study identifier
Secondary identifiers
observational
75
1 country
1
Study Start
October 9, 2001
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
October 4, 2010
Date type not reportedThis date has not been verified as actual or estimated.
This study will examine how the brain operates during execution and control of voluntary movement and what goes wrong with these processes in disease. It will use electroencephalography (EEG) and electromyography (EMG) to compare brain function in normal subjects and in patients with focal hand dystonia. In dystonia, involuntary muscle movements, or spasms, cause uncontrolled twisting and repetitive movement or abnormal postures. Focal dystonia involves just one region of the body, such as the hand, neck or face. EEG measures the electrical activity of the brain. The activity is recorded using wire electrodes attached to the scalp or mounted on a Lycra cap placed on the head. EMG measures electrical activity from muscles. It uses wire electrodes placed on the skin over the muscles. Adult healthy normal volunteers and patients with focal hand dystonia may be eligible for this study. Patients will be selected from NINDS's dystonia patient database. Participants will sit in a semi-reclining chair in a darkened room and be asked to move either their right index finger, right foot, or the angle of their mouth on the right side at a rate of one movement every 10 seconds. Brain and muscle activity will be measured during this task with EEG and EMG recordings.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
October 4, 2010
Date type not reportedThis date has not been verified as actual or estimated.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
October 9, 2001
Date type not reportedThis date has not been verified as actual or estimated.
October 11, 2001
Actual (reported)October 12, 2001
Actual (reported)October 4, 2010
Date type not reportedThis date has not been verified as actual or estimated.
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, 20892, United States
Bara-Jimenez W, Catalan MJ, Hallett M, Gerloff C. Abnormal somatosensory homunculus in dystonia of the hand. Ann Neurol. 1998 Nov;44(5):828-31. doi: 10.1002/ana.410440520.
Allard T, Clark SA, Jenkins WM, Merzenich MM. Reorganization of somatosensory area 3b representations in adult owl monkeys after digital syndactyly. J Neurophysiol. 1991 Sep;66(3):1048-58. doi: 10.1152/jn.1991.66.3.1048.
Abbruzzese G, Marchese R, Buccolieri A, Gasparetto B, Trompetto C. Abnormalities of sensorimotor integration in focal dystonia: a transcranial magnetic stimulation study. Brain. 2001 Mar;124(Pt 3):537-45. doi: 10.1093/brain/124.3.537.
75 participants (actual enrollment reported by the registry).
First Submitted
October 11, 2001
First Posted
October 12, 2001
Study Start
October 9, 2001
Date type not reportedThis date has not been verified as actual or estimated.
Brain Changes in Patients With Focal Hand Dystonia
Contact the study team to confirm eligibility.
Study Completion
October 4, 2010
Date type not reportedThis date has not been verified as actual or estimated.
Last Updated
July 2, 2017
Record last verified: 2010-10-04
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Source: ClinicalTrials.gov.
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