Neurophysiology of Task-Specificity of Focal Hand Dystonia

NCT00309010 | Completed

• 2 other identifiers: 06012606-N-0126
• Study Type: observational
• Target: 115
• Locations: 1 country
• Sites: 1

Brief Summary

This study will examine how the brain coordinates movement in patients with focal hand dystonia. Patients with dystonia have muscle spasms that cause uncontrolled twisting and repetitive movement or abnormal postures. In focal dystonia, just one part of the body, such as the hand, neck or face, is involved. This study will use transcranial magnetic stimulation (TMS, see below) to study how the brain plans movement. Healthy volunteers and patients with focal hand dystonia 18 years of age and older may be eligible for this study. Healthy subjects may participate in one, two or three of the experiments described below. Patients with dystonia may participate in experiments one and three. Before each experiment, each subject is asked about his/her medical and neurologic history, complete questionnaires and will undergo a brief physical examination. Experiment 1

• Surface EMG: Small electrodes are taped to the skin over the arm to measure the electrical activity of muscles.
• TMS: A wire coil is held on the subject's scalp. A brief electrical current is passed through the coil, creating a magnetic pulse that stimulates the brain. During the stimulation, the subject may be asked to tense certain muscles slightly or perform other simple actions. The stimulation may cause a twitch in muscles of the face, arm, or leg, and the subject may hear a click and feel a pulling sensation on the skin under the coil. Experiment 2 (Two visits.)
• Visit 1: Magnetic resonance imaging (MRI): This test uses a magnetic field and radio waves to obtain images of body tissues and organs. The patient lies on a table that is moved into the scanner (a metal cylinder), wearing earplugs to muffle loud knocking and thumping sounds that occur during the scanning process. The procedure lasts about 90 minutes, during which time the patient will be asked to lie still for up to 30 minutes at a time.
• Visit 2: Surface EMG and TMS Experiment 3
• Surface EMG and TMS - During the TMS, subjects are asked to respond to shapes on a computer screen by pushing a button or pressing a foot petal.

Conditions

Focal Dystonia

Keywords

Focal Hand Dystonia; Motor Planning; Transcranial Magnetic Stimulation (TMS); MRI (Magnetic Resonance Imaging); FHD; Writer's Cramp; Healthy Volunteer; HV

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients:
• Age over 18 years
• Presence of FHD, specifically writer's cramp
• Healthy volunteers:
• Age over 18 years
• Absence of dystonia or other neurologic condition

You may not qualify if:

• Patients and Healthy volunteers:
• Concurrent medical, surgical, neurologic or psychiatric condition
• Taking medications which include antidepressants, anxiolytics, anticonvulsants, antipsychotics, antiparkinson, hypnotics, stimulants, and/or antihistamines
• Received botulinum toxin injection within 3 months of starting the protocol
• Presence of pacemaker, implanted medical pump, metal plate or metal object in skull or eye
• History of seizure disorder
• For healthy volunteers undergoing MRI, subjects with implanted devices such as pacemakers, medication pumps or defibrillators, metal in the cranium except mouth, intracardiac lines, history of shrapnel injury or any other condition/device that may be contraindicated or prevent the acquisition of MRI and/or current pregnancy
• A serious medical illness which prevents them from lying flat for up to 60 minutes
• Claustrophobia (a fear of tight spaces), which prevents them from lying still in a tight or small space for up to 60 minutes

Sponsors & Collaborators

• National Institute of Neurological Disorders and Stroke (NINDS): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Hallett M. Dystonia: abnormal movements result from loss of inhibition. Adv Neurol. 2004;94:1-9. No abstract available.

  PMID: 14509648 BACKGROUND

• Bressman SB. Dystonia genotypes, phenotypes, and classification. Adv Neurol. 2004;94:101-7. No abstract available.

  PMID: 14509661 BACKGROUND

• Chen R, Hallett M. Focal dystonia and repetitive motion disorders. Clin Orthop Relat Res. 1998 Jun;(351):102-6.

  PMID: 9646753 BACKGROUND

MeSH Terms

Conditions

Dystonic Disorders; Dystonia, Focal, Task-Specific

Condition Hierarchy (Ancestors)

Movement Disorders; Central Nervous System Diseases; Nervous System Diseases

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: March 29, 2006
• First Posted: March 30, 2006
• Study Start: March 28, 2006
• Study Completion: February 24, 2009
• Last Updated: July 2, 2017

Record last verified: 2009-02-24

Locations

US (1)