Blood and Marrow Transplant Clinical Research Network

NCT00023530 | Completed

• 2 other identifiers: 139U01HL069301
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 16

Brief Summary

The purpose of this network is to accelerate research in hematopoietic stem cell transplantation by comparing novel therapies to existing ones.

Conditions

Bone Marrow Transplantation; Blood Disease; Hematopoietic Stem Cell Transplantation; Leukemia; Multiple Myeloma; Myelodysplastic Syndromes; Graft vs Host Disease

Interventions

fluconazole DRUG

voriconazole DRUG

bone marrow transplant PROCEDURE

thalidomide DRUG

dexamethasone DRUG

Eligibility Criteria

• Age: 2 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

Criteria for entry into a study varies by protocol

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI): lead
• Blood and Marrow Transplant Clinical Trials Network: collaborator

Study Sites (16)

City of Hope National Medical Center

Duarte, California, 91010, United States

Location

University of California at San Diego

La Jolla, California, 92093, United States

Location

Stanford University

Palo Alto, California, 94305, United States

Location

University of Florida

Gainesville, Florida, 32610, United States

Location

Johns Hopkins University

Baltimore, Maryland, 21231, United States

Location

Dana-Farber Cancer Institute

Boston, Massachusetts, 02115, United States

Location

University of Michigan at Ann Arbor

Ann Arbor, Michigan, 48109, United States

Location

University of Minnesota Twin Cities

Minneapolis, Minnesota, 55455, United States

Location

Children's Mercy Hospital

Kansas City, Missouri, 64108, United States

Location

University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States

Location

Sloan-Kettering Institute for Cancer Research

New York, New York, 10021, United States

Location

Duke University

Durham, North Carolina, 27705, United States

Location

Case Western Reserve University

Cleveland, Ohio, 44106, United States

Location

University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

Location

MD Anderson Cancer Center

Houston, Texas, 77030, United States

Location

Fred Hutchinson Cancer Research Center

Seattle, Washington, 98109, United States

Location

Related Publications (1)

• Wingard JR. Design issues in a prospective randomized double-blinded trial of prophylaxis with fluconazole versus voriconazole after allogeneic hematopoietic cell transplantation. Clin Infect Dis. 2004 Oct 15;39 Suppl 4:S176-80. doi: 10.1086/421953.

  PMID: 15546114 BACKGROUND

MeSH Terms

Conditions

Hematologic Diseases; Leukemia; Multiple Myeloma; Myelodysplastic Syndromes; Graft vs Host Disease

Interventions

Fluconazole; Voriconazole; Bone Marrow Transplantation; Thalidomide; Dexamethasone

Condition Hierarchy (Ancestors)

Hemic and Lymphatic Diseases; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Plasma Cell; Hemostatic Disorders; Vascular Diseases; Cardiovascular Diseases; Paraproteinemias; Blood Protein Disorders; Hemorrhagic Disorders; Lymphoproliferative Disorders; Immunoproliferative Disorders; Immune System Diseases; Bone Marrow Diseases

Intervention Hierarchy (Ancestors)

Triazoles; Azoles; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds; Tissue Transplantation; Cell- and Tissue-Based Therapy; Biological Therapy; Therapeutics; Transplantation; Surgical Procedures, Operative; Phthalimides; Phthalic Acids; Acids, Carbocyclic; Carboxylic Acids; Organic Chemicals; Piperidones; Piperidines; Isoindoles; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Pregnadienetriols; Pregnadienes; Pregnanes; Steroids; Fused-Ring Compounds; Polycyclic Compounds; Steroids, Fluorinated

Study Officials

• Joseph Antin

  Dana-Farber Cancer Institute

• Frederick Appelbaum

  Fred Hutchinson Cancer Center

• Edward Ball

  University of California, San Diego

• James Ferrara

  University of Michigan at Ann Arbor

• Stephen Forman

  City of Hope National Medical Center

• Alan Gamis

  Children's Mercy Hospital Kansas City

• Sergio Giralt

  M.D. Anderson Cancer Center

• Mary Horowitz

  Medical College of Wisconsin

• Richard Jones

  Johns Hopkins University

• Joanne Kurtzberg

  Duke University

• Gina Laport

  Stanford University

• Hillard Lazarus

  Case Western Reserve University

• Richard O'Reilly

  Sloan-Kettering Institute for Cancer Research

• Edward Stadtmauer

  University of Pennsylvania

• Julie Vose

  University of Nebraska

• Daniel Weisdorf

  University of Minnesota

• John Wingard

  University of Florida

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Purpose: PREVENTION
• Sponsor Type: NIH

Study Record Dates

• First Submitted: September 7, 2001
• First Posted: September 7, 2001
• Study Start: September 1, 2001
• Study Completion: August 1, 2006
• Last Updated: February 18, 2016

Record last verified: 2006-07

Locations

US (16)