NCT00006064|Completed
The Effect of Anti-HIV Treatment on Body Characteristics of HIV-Infected Children
Effect of Antiretroviral Therapy on Body Composition in HIV-Infected Children
Loading search results
Effect of Antiretroviral Therapy on Body Composition in HIV-Infected Children
Sponsor study identifier
Secondary identifiers
REGISTRY · DAIDS ES
observational
100
2 countries
3
Study Start
June 2000
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
February 2005
Actual (reported)The purpose of this study is to see how beginning or changing anti-HIV medications affects the body composition (weight, height, growth, body fat, and muscle mass, or fat and muscle distribution) of HIV-infected children. This study also looks at how changes in body composition relate to changes in viral load (level of HIV in the blood), CD4 cell counts, height, and weight in HIV-infected children. This study also compares changes in body composition to levels of cytokines (proteins in the body that affect some immune cells) in HIV-infected children who are beginning or changing anti-HIV therapy. Though studies have been done on adults, little is known about the effects of HIV infection and anti-HIV drugs on body composition in children. One theory is that changes in body composition can predict the failure of anti-HIV treatment. If this is true, body composition measurements can be as useful as CD4+ cell counts in determining drug effectiveness.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
February 2005
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
June 2000
Date type not reportedThis date has not been verified as actual or estimated.
June 16, 2000
Actual (reported)August 31, 2001
Actual (reported)February 2005
Actual (reported)Jacobi Med. Ctr. Bronx NICHD CRS
The Bronx, New York, 10461, United States
Texas Children's Hosp. CRS
Houston, Texas, 77030, United States
University of Puerto Rico Pediatric HIV/AIDS Research Program CRS
San Juan, PR, 00935, Puerto Rico
Chantry CJ, Hughes MD, Alvero C, Cervia JS, Hodge J, Borum P, Moye J Jr; PACTG 1010 Team. Insulin-like growth factor-1 and lean body mass in HIV-infected children. J Acquir Immune Defic Syndr. 2008 Aug 1;48(4):437-43. doi: 10.1097/QAI.0b013e31817bbe6d.
Chantry CJ, Hughes MD, Alvero C, Cervia JS, Meyer WA 3rd, Hodge J, Borum P, Moye J Jr; PACTG 1010 Team. Lipid and glucose alterations in HIV-infected children beginning or changing antiretroviral therapy. Pediatrics. 2008 Jul;122(1):e129-38. doi: 10.1542/peds.2007-2467. Epub 2008 Jun 2.
Caroline Chantry
Joseph Cervia
First Submitted
June 16, 2000
First Posted
August 31, 2001
Study Start
June 2000
Date type not reportedThis date has not been verified as actual or estimated.
Study Completion
February 2005
Actual (reported)Changing to Nonprotease Inhibitor Treatment to Improve Side Effects
Contact the study team to confirm eligibility.
Chantry CJ, Cervia JS, Hughes MD, Alvero C, Hodge J, Borum P, Moye J Jr; PACTG 1010 Team. Predictors of growth and body composition in HIV-infected children beginning or changing antiretroviral therapy. HIV Med. 2010 Oct 1;11(9):573-83. doi: 10.1111/j.1468-1293.2010.00823.x. Epub 2010 Mar 21.
Cervia JS, Chantry CJ, Hughes MD, Alvero C, Meyer WA 3rd, Hodge J, Borum P, Moye J Jr, Spector SA; PACTG 1010 Team. Associations of proinflammatory cytokine levels with lipid profiles, growth, and body composition in HIV-infected children initiating or changing antiretroviral therapy. Pediatr Infect Dis J. 2010 Dec;29(12):1118-22. doi: 10.1097/INF.0b013e3181ed9f4c.
Last Updated
October 29, 2014
Record last verified: 2014-10
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: