Identifying Genes Involved in Abnormal Blood Pressure - Hypertension SCOR
2 other identifiers
observational
N/A
0 countries
N/A
Brief Summary
To seek out genes or genetic markers which identify subjects more vulnerable to hypertension under the influence of environmental factors.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
Started Feb 1996
Longer than P75 for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 1996
CompletedFirst Submitted
Initial submission to the registry
May 25, 2000
CompletedFirst Posted
Study publicly available on registry
May 26, 2000
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2006
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2006
CompletedJuly 16, 2014
July 1, 2014
10.4 years
May 25, 2000
July 15, 2014
Conditions
Eligibility Criteria
Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.
Sponsors & Collaborators
Related Publications (7)
Baima J, Nicolaou M, Schwartz F, DeStefano AL, Manolis A, Gavras I, Laffer C, Elijovich F, Farrer L, Baldwin CT, Gavras H. Evidence for linkage between essential hypertension and a putative locus on human chromosome 17. Hypertension. 1999 Jul;34(1):4-7. doi: 10.1161/01.hyp.34.1.4.
PMID: 10406815BACKGROUNDLevy D, DeStefano AL, Larson MG, O'Donnell CJ, Lifton RP, Gavras H, Cupples LA, Myers RH. Evidence for a gene influencing blood pressure on chromosome 17. Genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the framingham heart study. Hypertension. 2000 Oct;36(4):477-83. doi: 10.1161/01.hyp.36.4.477.
PMID: 11040222BACKGROUNDNicolaou M, DeStefano AL, Gavras I, Cupples LA, Manolis AJ, Baldwin CT, Gavras H, Farrer LA. Genetic predisposition to stroke in relatives of hypertensives. Stroke. 2000 Feb;31(2):487-92. doi: 10.1161/01.str.31.2.487.
PMID: 10657427BACKGROUNDErlich PM, Cui J, Chazaro I, Farrer LA, Baldwin CT, Gavras H, DeStefano AL. Genetic variants of WNK4 in whites and African Americans with hypertension. Hypertension. 2003 Jun;41(6):1191-5. doi: 10.1161/01.HYP.0000070025.30572.91. Epub 2003 Apr 28.
PMID: 12719438BACKGROUNDZhou XF, Cui J, DeStefano AL, Chazaro I, Farrer LA, Manolis AJ, Gavras H, Baldwin CT. Polymorphisms in the promoter region of catalase gene and essential hypertension. Dis Markers. 2005;21(1):3-7. doi: 10.1155/2005/487014.
PMID: 15735318BACKGROUNDManolis AJ, Iraklianou S, Pittaras A, Zaris M, Tsioufis K, Psaltiras G, Psomali D, Foussas S, Gavras I, Gavras H. Arterial compliance changes in diabetic normotensive patients after angiotensin-converting enzyme inhibition therapy. Am J Hypertens. 2005 Jan;18(1):18-22. doi: 10.1016/j.amjhyper.2004.08.014.
PMID: 15691612BACKGROUNDCui J, Melista E, Chazaro I, Zhang Y, Zhou X, Manolis AJ, Baldwin CT, Destefano AL, Gavras H. Sequence variation of bradykinin receptors B1 and B2 and association with hypertension. J Hypertens. 2005 Jan;23(1):55-62. doi: 10.1097/00004872-200501000-00013.
PMID: 15643125BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
Haralambos Gavras
Boston University
Study Design
- Study Type
- observational
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
May 25, 2000
First Posted
May 26, 2000
Study Start
February 1, 1996
Primary Completion
July 1, 2006
Study Completion
July 1, 2006
Last Updated
July 16, 2014
Record last verified: 2014-07