NCT00005476

Brief Summary

To establish the aspects of ethnicity that are associated with the differential expression of cardiovascular disease processes in African Americans and Caucasian Americans twin children.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Sep 1996

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 1996

Completed
3.7 years until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
5.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 1, 2005

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2005

Completed
Last Updated

July 29, 2016

Status Verified

May 1, 2009

Enrollment Period

9.2 years

First QC Date

May 25, 2000

Last Update Submit

July 28, 2016

Conditions

Cardiovascular DiseasesHeart DiseasesHypertension

Eligibility Criteria

AgeUp to 100 Years
Sexmale
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (10)

  • Jackson RW, Snieder H, Davis H, Treiber FA. Determination of twin zygosity: a comparison of DNA with various questionnaire indices. Twin Res. 2001 Feb;4(1):12-8. doi: 10.1375/1369052012092.

    PMID: 11665319BACKGROUND

  • Davis CL, Kapuku G, Snieder H, Kumar M, Treiber FA. Insulin resistance syndrome and left ventricular mass in healthy young people. Am J Med Sci. 2002 Aug;324(2):72-5. doi: 10.1097/00000441-200208000-00005.

    PMID: 12186110BACKGROUND

  • Snieder H, Harshfield GA, Barbeau P, Pollock DM, Pollock JS, Treiber FA. Dissecting the genetic architecture of the cardiovascular and renal stress response. Biol Psychol. 2002 Oct;61(1-2):73-95. doi: 10.1016/s0301-0511(02)00053-4.

    PMID: 12385670BACKGROUND

  • Barbeau P, Litaker MS, Jackson RW, Treiber FA. A tyrosine hydroxylase microsatellite and hemodynamic response to stress in a multi-ethnic sample of youth. Ethn Dis. 2003 Spring;13(2):186-92.

    PMID: 12785414BACKGROUND

  • Snieder H, Treiber FA. The Georgia Cardiovascular Twin Study. Twin Res. 2002 Oct;5(5):497-8. doi: 10.1375/136905202320906354.

    PMID: 12537884BACKGROUND

  • Snieder H, Dong Y, Barbeau P, Harshfield GA, Dalageogou C, Zhu H, Carter ND, Treiber FA. Beta2-adrenergic receptor gene and resting hemodynamics in European and African American youth. Am J Hypertens. 2002 Nov;15(11):973-9. doi: 10.1016/s0895-7061(02)02991-6.

    PMID: 12441217BACKGROUND

  • Snieder H, Harshfield GA, Treiber FA. Heritability of blood pressure and hemodynamics in African- and European-American youth. Hypertension. 2003 Jun;41(6):1196-201. doi: 10.1161/01.HYP.0000072269.19820.0D. Epub 2003 Apr 28.

    PMID: 12719445BACKGROUND

  • Wang X, Trivedi R, Treiber F, Snieder H. Genetic and environmental influences on anger expression, John Henryism, and stressful life events: the Georgia Cardiovascular Twin Study. Psychosom Med. 2005 Jan-Feb;67(1):16-23. doi: 10.1097/01.psy.0000146331.10104.d4.

    PMID: 15673619BACKGROUND

  • Iliadou A, Snieder H, Wang X, Treiber FA, Davis CL. Heritabilities of lipids in young European American and African American twins. Twin Res Hum Genet. 2005 Oct;8(5):492-8. doi: 10.1375/183242705774310187.

    PMID: 16212838BACKGROUND

  • Imumorin IG, Dong Y, Zhu H, Poole JC, Harshfield GA, Treiber FA, Snieder H. A gene-environment interaction model of stress-induced hypertension. Cardiovasc Toxicol. 2005;5(2):109-32. doi: 10.1385/ct:5:2:109.

    PMID: 16046788BACKGROUND

MeSH Terms

Conditions

Cardiovascular DiseasesHeart DiseasesHypertension

Condition Hierarchy (Ancestors)

Vascular Diseases

Study Officials

  • Frank Treiber

    Augusta University

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

September 1, 1996

Primary Completion

November 1, 2005

Study Completion

November 1, 2005

Last Updated

July 29, 2016

Record last verified: 2009-05