Family Blood Pressure Program - HyperGEN

NCT00005267 | Completed

• 2 other identifiers: 11515R01HL055673-15
• Study Type: observational
• Target: 3,604
• Locations: 0 countries
• Sites: N/A

Brief Summary

To map and identify the major genetic determinants of hypertension and to study possible interactions between genetic and non-genetic factors in defined populations. HyperGEN initially consisted of a nine grant network, which in turn is part of an NHLBI initiative, the Family Blood Pressure Program (FBPP) consisting of four networks.

Conditions

Cardiovascular Diseases; Heart Diseases; Hypertension

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

(A) sample of hypertensive sibships with at least two members diagnosed with hypertension before the age of 60 (probands); (B) random sample of age-matched persons from the same base populations, from which normotensive controls could be drawn; (C) unmedicated, normotensive adult offspring of one of the hypertensive siblings.

Sponsors & Collaborators

• University of Alabama at Birmingham: lead
• National Heart, Lung, and Blood Institute (NHLBI): collaborator

Related Publications (60)

• Province MA, Boerwinkle E, Chakravarti A, Cooper R, Fornage M, Leppert M, Risch N, Ranade K. Lack of association of the angiotensinogen-6 polymorphism with blood pressure levels in the comprehensive NHLBI Family Blood Pressure Program. National Heart, Lung and Blood Institute. J Hypertens. 2000 Jul;18(7):867-76. doi: 10.1097/00004872-200018070-00008.

  PMID: 10930184 BACKGROUND

• Williams RR, Rao DC, Ellison RC, Arnett DK, Heiss G, Oberman A, Eckfeldt JH, Leppert MF, Province MA, Mockrin SC, Hunt SC. NHLBI family blood pressure program: methodology and recruitment in the HyperGEN network. Hypertension genetic epidemiology network. Ann Epidemiol. 2000 Aug;10(6):389-400. doi: 10.1016/s1047-2797(00)00063-6.

  PMID: 10964005 BACKGROUND

• Province MA, Arnett DK, Hunt SC, Leiendecker-Foster C, Eckfeldt JH, Oberman A, Ellison RC, Heiss G, Mockrin SC, Williams RR. Association between the alpha-adducin gene and hypertension in the HyperGEN Study. Am J Hypertens. 2000 Jun;13(6 Pt 1):710-8. doi: 10.1016/s0895-7061(99)00282-4.

  PMID: 10912758 BACKGROUND

• Province MA. Sequential methods of analysis for genome scans. Adv Genet. 2001;42:499-514. doi: 10.1016/s0065-2660(01)42039-6.

  PMID: 11037338 BACKGROUND

• Palmieri V, Bella JN, Arnett DK, Liu JE, Oberman A, Schuck MY, Kitzman DW, Hopkins PN, Morgan D, Rao DC, Devereux RB. Effect of type 2 diabetes mellitus on left ventricular geometry and systolic function in hypertensive subjects: Hypertension Genetic Epidemiology Network (HyperGEN) study. Circulation. 2001 Jan 2;103(1):102-7. doi: 10.1161/01.cir.103.1.102.

  PMID: 11136693 BACKGROUND

• DeWan AT, Arnett DK, Atwood LD, Province MA, Lewis CE, Hunt SC, Eckfeldt J. A genome scan for renal function among hypertensives: the HyperGEN study. Am J Hum Genet. 2001 Jan;68(1):136-144. doi: 10.1086/316927. Epub 2000 Dec 12.

  PMID: 11115379 BACKGROUND

• de Simone G, Palmieri V, Bella JN, Celentano A, Hong Y, Oberman A, Kitzman DW, Hopkins PN, Arnett DK, Devereux RB. Association of left ventricular hypertrophy with metabolic risk factors: the HyperGEN study. J Hypertens. 2002 Feb;20(2):323-31. doi: 10.1097/00004872-200202000-00024.

  PMID: 11821719 BACKGROUND

• Arnett DK, Hong Y, Bella JN, Oberman A, Kitzman DW, Hopkins PN, Rao DC, Devereux RB. Sibling correlation of left ventricular mass and geometry in hypertensive African Americans and whites: the HyperGEN study. Hypertension Genetic Epidemiology Network. Am J Hypertens. 2001 Dec;14(12):1226-30. doi: 10.1016/s0895-7061(01)02200-2.

  PMID: 11775131 BACKGROUND

• Arnett DK, Devereux RB, Kitzman D, Oberman A, Hopkins P, Atwood L, Dewan A, Rao DC; Hypertension Genetic Epidemiology Network Study Group. Linkage of left ventricular contractility to chromosome 11 in humans: The HyperGEN Study. Hypertension. 2001 Oct;38(4):767-72. doi: 10.1161/hy1001.092650.

  PMID: 11641284 BACKGROUND

• Bella JN, Palmieri V, Liu JE, Kitzman DW, Oberman A, Hunt SC, Hopkins PN, Rao DC, Arnett DK, Devereux RB; Hypertension Genetic Epidemiology Network Study Group. Relationship between left ventricular diastolic relaxation and systolic function in hypertension: The Hypertension Genetic Epidemiology Network (HyperGEN) Study. Hypertension. 2001 Sep;38(3):424-8. doi: 10.1161/01.hyp.38.3.424.

  PMID: 11566916 BACKGROUND

• Devereux RB, Bella JN, Palmieri V, Oberman A, Kitzman DW, Hopkins PN, Rao DC, Morgan D, Paranicas M, Fishman D, Arnett DK; Hypertension Genetic Epidemiology Network Study Group. Left ventricular systolic dysfunction in a biracial sample of hypertensive adults: The Hypertension Genetic Epidemiology Network (HyperGEN) Study. Hypertension. 2001 Sep;38(3):417-23. doi: 10.1161/01.hyp.38.3.417.

  PMID: 11566915 BACKGROUND

• Palmieri V, Bella JN, Arnett DK, Roman MJ, Oberman A, Kitzman DW, Hopkins PN, Paranicas M, Rao DC, Devereux RB. Aortic root dilatation at sinuses of valsalva and aortic regurgitation in hypertensive and normotensive subjects: The Hypertension Genetic Epidemiology Network Study. Hypertension. 2001 May;37(5):1229-35. doi: 10.1161/01.hyp.37.5.1229.

  PMID: 11358933 BACKGROUND

• Wu X, Cooper RS, Borecki I, Hanis C, Bray M, Lewis CE, Zhu X, Kan D, Luke A, Curb D. A combined analysis of genomewide linkage scans for body mass index from the National Heart, Lung, and Blood Institute Family Blood Pressure Program. Am J Hum Genet. 2002 May;70(5):1247-56. doi: 10.1086/340362. Epub 2002 Mar 28.

  PMID: 11923912 BACKGROUND

• Coon H, Leppert MF, Eckfeldt JH, Oberman A, Myers RH, Peacock JM, Province MA, Hopkins PN, Heiss G. Genome-wide linkage analysis of lipids in the Hypertension Genetic Epidemiology Network (HyperGEN) Blood Pressure Study. Arterioscler Thromb Vasc Biol. 2001 Dec;21(12):1969-76. doi: 10.1161/hq1201.100228.

  PMID: 11742872 BACKGROUND

• Palmieri V, de Simone G, Arnett DK, Bella JN, Kitzman DW, Oberman A, Hopkins PN, Province MA, Devereux RB. Relation of various degrees of body mass index in patients with systemic hypertension to left ventricular mass, cardiac output, and peripheral resistance (The Hypertension Genetic Epidemiology Network Study). Am J Cardiol. 2001 Nov 15;88(10):1163-8. doi: 10.1016/s0002-9149(01)02054-9.

  PMID: 11703964 BACKGROUND

• Bella JN, Palmieri V, Kitzman DW, Liu JE, Oberman A, Hunt SC, Hopkins PN, Rao DC, Arnett DK, Devereux RB. Gender difference in diastolic function in hypertension (the HyperGEN study). Am J Cardiol. 2002 May 1;89(9):1052-6. doi: 10.1016/s0002-9149(02)02274-9.

  PMID: 11988194 BACKGROUND

• Tang W, Devereux RB, Rao DC, Oberman A, Hopkins PN, Kitzman DW, Arnett DK. Associations between angiotensinogen gene variants and left ventricular mass and function in the HyperGEN study. Am Heart J. 2002 May;143(5):854-60. doi: 10.1067/mhj.2002.121926.

  PMID: 12040348 BACKGROUND

• Palmieri V, Arnett DK, Roman MJ, Liu JE, Bella JN, Oberman A, Kitzman DW, Hopkins PN, Morgan D, de Simone G, Devereux RB. Appetite suppressants and valvular heart disease in a population-based sample: the HyperGEN study. Am J Med. 2002 Jun 15;112(9):710-5. doi: 10.1016/s0002-9343(02)01123-3.

  PMID: 12079711 BACKGROUND

• Tang W, Arnett DK, Devereux RB, Atwood LD, Kitzman DW, Rao DC. Linkage of left ventricular early diastolic peak filling velocity to chromosome 5 in hypertensive African Americans: the HyperGEN echocardiography study. Am J Hypertens. 2002 Jul;15(7 Pt 1):621-7. doi: 10.1016/s0895-7061(02)02943-6.

  PMID: 12118910 BACKGROUND

• Wilk JB, Myers RH, Zhang Y, Lewis CE, Atwood L, Hopkins PN, Ellison RC. Evidence for a gene influencing heart rate on chromosome 4 among hypertensives. Hum Genet. 2002 Aug;111(2):207-13. doi: 10.1007/s00439-002-0780-9. Epub 2002 Jul 16.

  PMID: 12189495 BACKGROUND

• Devereux RB, de Simone G, Palmieri V, Oberman A, Hopkins P, Kitzman DW, Rao DC, Arnett DK. Relation of insulin to left ventricular geometry and function in African American and white hypertensive adults: the HyperGEN study. Am J Hypertens. 2002 Dec;15(12):1029-35. doi: 10.1016/s0895-7061(02)03080-7.

  PMID: 12460697 BACKGROUND

• al'Absi M, Devereux RB, Lewis CE, Kitzman DW, Rao DC, Hopkins P, Markovitz J, Arnett DK. Blood pressure responses to acute stress and left ventricular mass (The Hypertension Genetic Epidemiology Network Study). Am J Cardiol. 2002 Mar 1;89(5):536-40. doi: 10.1016/s0002-9149(01)02305-0.

  PMID: 11867037 BACKGROUND

• Tang W, Arnett DK, Devereux RB, Province MA, Atwood LD, Oberman A, Hopkins PN, Kitzman DW. Sibling resemblance for left ventricular structure, contractility, and diastolic filling. Hypertension. 2002 Sep;40(3):233-8. doi: 10.1161/01.hyp.0000028487.62501.12.

  PMID: 12215459 BACKGROUND

• DeWan AT, Arnett DK, Miller MB, Peacock JM, Atwood LD, Province MA, Lewis CE, Hunt SC, Eckfeldt JH. Refined mapping of suggestive linkage to renal function in African Americans: the HyperGEN study. Am J Hum Genet. 2002 Jul;71(1):204-5. doi: 10.1086/340730. No abstract available.

  PMID: 12068377 BACKGROUND

• Province MA, Kardia SL, Ranade K, Rao DC, Thiel BA, Cooper RS, Risch N, Turner ST, Cox DR, Hunt SC, Weder AB, Boerwinkle E; National Heart, Lung and Blood Institute Family Blood Pressure Program. A meta-analysis of genome-wide linkage scans for hypertension: the National Heart, Lung and Blood Institute Family Blood Pressure Program. Am J Hypertens. 2003 Feb;16(2):144-7. doi: 10.1016/s0895-7061(02)03248-x.

  PMID: 12559682 BACKGROUND

• Rao DC, Province MA, Leppert MF, Oberman Al, Heiss G, Ellison RC, Arnett DK, Eckfeldt JH, Schwander K, Mockrin SC, Hunt SC; HyperGEN Network. A genome-wide affected sibpair linkage analysis of hypertension: the HyperGEN network. Am J Hypertens. 2003 Feb;16(2):148-50. doi: 10.1016/s0895-7061(02)03247-8.

  PMID: 12559683 BACKGROUND

• Palmieri V, Bella JN, Arnett DK, Oberman A, Kitzman DW, Hopkins PN, Rao DC, Roman MJ, Devereux RB; Hypertension Genetic Epidemiology Network study. Associations of aortic and mitral regurgitation with body composition and myocardial energy expenditure in adults with hypertension: the Hypertension Genetic Epidemiology Network study. Am Heart J. 2003 Jun;145(6):1071-7. doi: 10.1016/S0002-8703(03)00099-1.

  PMID: 12796765 BACKGROUND

• Freedman BI, Beck SR, Rich SS, Heiss G, Lewis CE, Turner S, Province MA, Schwander KL, Arnett DK, Mellen BG; HyperGEN Investigators. A genome-wide scan for urinary albumin excretion in hypertensive families. Hypertension. 2003 Sep;42(3):291-6. doi: 10.1161/01.HYP.0000087890.33245.41. Epub 2003 Aug 18.

  PMID: 12925555 BACKGROUND

• de Simone G, Devereux RB, Palmieri V, Bella JN, Oberman A, Kitzman DW, Hopkins PN, Rao DC, Arnett DK; HyperGEN Study. Influence of fat-free mass on detection of appropriateness of left ventricular mass: the HyperGEN Study. J Hypertens. 2003 Sep;21(9):1747-52. doi: 10.1097/00004872-200309000-00025.

  PMID: 12923408 BACKGROUND

• Kizer JR, Arnett DK, Bella JN, Paranicas M, Rao DC, Province MA, Oberman A, Kitzman DW, Hopkins PN, Liu JE, Devereux RB. Differences in left ventricular structure between black and white hypertensive adults: the Hypertension Genetic Epidemiology Network study. Hypertension. 2004 Jun;43(6):1182-8. doi: 10.1161/01.HYP.0000128738.94190.9f. Epub 2004 May 3.

  PMID: 15123573 BACKGROUND

• Barkley RA, Chakravarti A, Cooper RS, Ellison RC, Hunt SC, Province MA, Turner ST, Weder AB, Boerwinkle E; Family Blood Pressure Program. Positional identification of hypertension susceptibility genes on chromosome 2. Hypertension. 2004 Feb;43(2):477-82. doi: 10.1161/01.HYP.0000111585.76299.f7. Epub 2004 Jan 19.

  PMID: 14732741 BACKGROUND

• de Simone G, Kitzman DW, Palmieri V, Liu JE, Oberman A, Hopkins PN, Bella JN, Rao DC, Arnett DK, Devereux RB. Association of inappropriate left ventricular mass with systolic and diastolic dysfunction: the HyperGEN study. Am J Hypertens. 2004 Sep;17(9):828-33. doi: 10.1016/j.amjhyper.2004.04.008.

  PMID: 15363827 BACKGROUND

• Wilk JB, Djousse L, Arnett DK, Hunt SC, Province MA, Heiss G, Myers RH. Genome-wide linkage analyses for age at diagnosis of hypertension and early-onset hypertension in the HyperGEN study. Am J Hypertens. 2004 Sep;17(9):839-44. doi: 10.1016/j.amjhyper.2004.06.003.

  PMID: 15363829 BACKGROUND

• Morrison AC, Cooper R, Hunt S, Lewis CE, Luke A, Mosley TH, Boerwinkle E. Genome scan for hypertension in nonobese African Americans: the National Heart, Lung, and Blood Institute Family Blood Pressure Program. Am J Hypertens. 2004 Sep;17(9):834-8. doi: 10.1016/j.amjhyper.2004.04.009.

  PMID: 15363828 BACKGROUND

• Kraja AT, Hunt SC, Pankow JS, Myers RH, Heiss G, Lewis CE, Rao D, Province MA. An evaluation of the metabolic syndrome in the HyperGEN study. Nutr Metab (Lond). 2005 Jan 18;2(1):2. doi: 10.1186/1743-7075-2-2.

  PMID: 15656912 BACKGROUND

• de Simone G, Kitzman DW, Chinali M, Oberman A, Hopkins PN, Rao DC, Arnett DK, Devereux RB. Left ventricular concentric geometry is associated with impaired relaxation in hypertension: the HyperGEN study. Eur Heart J. 2005 May;26(10):1039-45. doi: 10.1093/eurheartj/ehi019. Epub 2004 Nov 30.

  PMID: 15618056 BACKGROUND

• North KE, Rose KM, Borecki IB, Oberman A, Hunt SC, Miller MB, Blangero J, Almasy L, Pankow JS. Evidence for a gene on chromosome 13 influencing postural systolic blood pressure change and body mass index. Hypertension. 2004 Apr;43(4):780-4. doi: 10.1161/01.HYP.0000118921.66329.da. Epub 2004 Feb 16.

  PMID: 14967843 BACKGROUND

• Tang H, Quertermous T, Rodriguez B, Kardia SL, Zhu X, Brown A, Pankow JS, Province MA, Hunt SC, Boerwinkle E, Schork NJ, Risch NJ. Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies. Am J Hum Genet. 2005 Feb;76(2):268-75. doi: 10.1086/427888. Epub 2004 Dec 29.

  PMID: 15625622 BACKGROUND

• Avery CL, Freedman BI, Heiss G, Kraja A, Rice T, Arnett D, Miller MB, Pankow JS, Lewis CE, Myers RH, Hunt SC, Almasy L, North KE; Hypertension Genetic Epidemiology Network. Linkage analysis of diabetes status among hypertensive families: the Hypertension Genetic Epidemiology Network study. Diabetes. 2004 Dec;53(12):3307-12. doi: 10.2337/diabetes.53.12.3307.

  PMID: 15561964 BACKGROUND

• Freedman BI, Rich SS, Sale MM, Heiss G, Djousse L, Pankow JS, Province MA, Rao DC, Lewis CE, Chen YD, Beck SR; HyperGEN Investigators. Genome-wide scans for heritability of fasting serum insulin and glucose concentrations in hypertensive families. Diabetologia. 2005 Apr;48(4):661-8. doi: 10.1007/s00125-005-1679-5. Epub 2005 Mar 4.

  PMID: 15747111 BACKGROUND

• An P, Freedman BI, Hanis CL, Chen YD, Weder AB, Schork NJ, Boerwinkle E, Province MA, Hsiung CA, Wu X, Quertermous T, Rao DC. Genome-wide linkage scans for fasting glucose, insulin, and insulin resistance in the National Heart, Lung, and Blood Institute Family Blood Pressure Program: evidence of linkages to chromosome 7q36 and 19q13 from meta-analysis. Diabetes. 2005 Mar;54(3):909-14. doi: 10.2337/diabetes.54.3.909.

  PMID: 15734873 BACKGROUND

• Zhu X, Luke A, Cooper RS, Quertermous T, Hanis C, Mosley T, Gu CC, Tang H, Rao DC, Risch N, Weder A. Admixture mapping for hypertension loci with genome-scan markers. Nat Genet. 2005 Feb;37(2):177-81. doi: 10.1038/ng1510. Epub 2005 Jan 23.

  PMID: 15665825 BACKGROUND

• Jorgenson E, Tang H, Gadde M, Province M, Leppert M, Kardia S, Schork N, Cooper R, Rao DC, Boerwinkle E, Risch N. Ethnicity and human genetic linkage maps. Am J Hum Genet. 2005 Feb;76(2):276-90. doi: 10.1086/427926. Epub 2004 Dec 30.

  PMID: 15627237 BACKGROUND

• de Simone G, Devereux RB, Kizer JR, Chinali M, Bella JN, Oberman A, Kitzman DW, Hopkins PN, Rao DC, Arnett DK. Body composition and fat distribution influence systemic hemodynamics in the absence of obesity: the HyperGEN Study. Am J Clin Nutr. 2005 Apr;81(4):757-61. doi: 10.1093/ajcn/81.4.757.

  PMID: 15817849 BACKGROUND

• Pankow JS, Dunn DM, Hunt SC, Leppert MF, Miller MB, Rao DC, Heiss G, Oberman A, Lalouel JM, Weiss RB. Further evidence of a quantitative trait locus on chromosome 18 influencing postural change in systolic blood pressure: the Hypertension Genetic Epidemiology Network (HyperGEN) Study. Am J Hypertens. 2005 May;18(5 Pt 1):672-8. doi: 10.1016/j.amjhyper.2004.12.004.

  PMID: 15882550 BACKGROUND

• Lynch AI, Arnett DK, Atwood LD, Devereux RB, Kitzman DW, Hopkins PN, Oberman A, Rao DC. A genome scan for linkage with aortic root diameter in hypertensive African Americans and whites in the Hypertension Genetic Epidemiology Network (HyperGEN) study. Am J Hypertens. 2005 May;18(5 Pt 1):627-32. doi: 10.1016/j.amjhyper.2004.11.029.

  PMID: 15882545 BACKGROUND

• Lewis CE, North KE, Arnett D, Borecki IB, Coon H, Ellison RC, Hunt SC, Oberman A, Rich SS, Province MA, Miller MB. Sex-specific findings from a genome-wide linkage analysis of human fatness in non-Hispanic whites and African Americans: the HyperGEN study. Int J Obes (Lond). 2005 Jun;29(6):639-49. doi: 10.1038/sj.ijo.0802916.

  PMID: 15809668 BACKGROUND

• North KE, Miller MB, Coon H, Martin LJ, Peacock JM, Arnett D, Zhang B, Province M, Oberman A, Blangero J, Almasy L, Ellison RC, Heiss G. Evidence for a gene influencing fasting LDL cholesterol and triglyceride levels on chromosome 21q. Atherosclerosis. 2005 Mar;179(1):119-25. doi: 10.1016/j.atherosclerosis.2004.09.009. Epub 2004 Nov 14.

  PMID: 15721017 BACKGROUND

• Agno FS, Chinali M, Bella JN, Liu JE, Arnett DK, Kitzman DW, Oberman A, Hopkins PN, Rao DC, Devereux RB. Aortic valve sclerosis is associated with preclinical cardiovascular disease in hypertensive adults: the Hypertension Genetic Epidemiology Network study. J Hypertens. 2005 Apr;23(4):867-73. doi: 10.1097/01.hjh.0000163157.14493.c7.

  PMID: 15775793 BACKGROUND

• Arnett DK, Tang W, Province MA, Oberman A, Ellison RC, Morgan D, Eckfeldt JH, Hunt SC. Interarm differences in seated systolic and diastolic blood pressure: the Hypertension Genetic Epidemiology Network study. J Hypertens. 2005 Jun;23(6):1141-7. doi: 10.1097/01.hjh.0000170376.23461.f7.

  PMID: 15894889 BACKGROUND

• Chinali M, de Simone G, Liu JE, Bella JN, Oberman A, Hopkins PN, Kitzman DW, Rao DC, Arnett DK, Devereux RB. Left atrial systolic force and cardiac markers of preclinical disease in hypertensive patients: the Hypertension Genetic Epidemiology Network (HyperGEN) Study. Am J Hypertens. 2005 Jul;18(7):899-905. doi: 10.1016/j.amjhyper.2005.01.005.

  PMID: 16053984 BACKGROUND

• Kraja AT, Rao DC, Weder AB, Mosley TH, Turner ST, Hsiung CA, Quertermous T, Cooper R, Curb JD, Province MA. An evaluation of the metabolic syndrome in a large multi-ethnic study: the Family Blood Pressure Program. Nutr Metab (Lond). 2005 Aug 2;2:17. doi: 10.1186/1743-7075-2-17.

  PMID: 16076393 BACKGROUND

• Kraja AT, Hunt SC, Pankow JS, Myers RH, Heiss G, Lewis CE, Rao DC, Province MA. Quantitative trait loci for metabolic syndrome in the Hypertension Genetic Epidemiology Network study. Obes Res. 2005 Nov;13(11):1885-90. doi: 10.1038/oby.2005.231.

  PMID: 16339118 BACKGROUND

• Bielinski SJ, Lynch AI, Miller MB, Weder A, Cooper R, Oberman A, Chen YD, Turner ST, Fornage M, Province M, Arnett DK. Genome-wide linkage analysis for loci affecting pulse pressure: the Family Blood Pressure Program. Hypertension. 2005 Dec;46(6):1286-93. doi: 10.1161/01.HYP.0000191706.41980.29. Epub 2005 Nov 14.

  PMID: 16286574 BACKGROUND

• Li W, Turner A, Aggarwal P, Matter A, Storvick E, Arnett DK, Broeckel U. Comprehensive evaluation of AmpliSeq transcriptome, a novel targeted whole transcriptome RNA sequencing methodology for global gene expression analysis. BMC Genomics. 2015 Dec 16;16:1069. doi: 10.1186/s12864-015-2270-1.

  PMID: 26673413 DERIVED

• Scantlebury DC, Kane GC, Wiste HJ, Bailey KR, Turner ST, Arnett DK, Devereux RB, Mosley TH Jr, Hunt SC, Weder AB, Rodriguez B, Boerwinkle E, Weissgerber TL, Garovic VD. Left ventricular hypertrophy after hypertensive pregnancy disorders. Heart. 2015 Oct;101(19):1584-90. doi: 10.1136/heartjnl-2015-308098. Epub 2015 Aug 4.

  PMID: 26243788 DERIVED

• Glasser SP, Lynch AI, Devereux RB, Hopkins P, Arnett DK. Hemodynamic and echocardiographic profiles in African American compared with White offspring of hypertensive parents: the HyperGEN study. Am J Hypertens. 2014 Jan;27(1):21-6. doi: 10.1093/ajh/hpt178. Epub 2013 Nov 16.

  PMID: 24242823 DERIVED

• Liu CT, Monda KL, Taylor KC, Lange L, Demerath EW, Palmas W, Wojczynski MK, Ellis JC, Vitolins MZ, Liu S, Papanicolaou GJ, Irvin MR, Xue L, Griffin PJ, Nalls MA, Adeyemo A, Liu J, Li G, Ruiz-Narvaez EA, Chen WM, Chen F, Henderson BE, Millikan RC, Ambrosone CB, Strom SS, Guo X, Andrews JS, Sun YV, Mosley TH, Yanek LR, Shriner D, Haritunians T, Rotter JI, Speliotes EK, Smith M, Rosenberg L, Mychaleckyj J, Nayak U, Spruill I, Garvey WT, Pettaway C, Nyante S, Bandera EV, Britton AF, Zonderman AB, Rasmussen-Torvik LJ, Chen YD, Ding J, Lohman K, Kritchevsky SB, Zhao W, Peyser PA, Kardia SL, Kabagambe E, Broeckel U, Chen G, Zhou J, Wassertheil-Smoller S, Neuhouser ML, Rampersaud E, Psaty B, Kooperberg C, Manson JE, Kuller LH, Ochs-Balcom HM, Johnson KC, Sucheston L, Ordovas JM, Palmer JR, Haiman CA, McKnight B, Howard BV, Becker DM, Bielak LF, Liu Y, Allison MA, Grant SF, Burke GL, Patel SR, Schreiner PJ, Borecki IB, Evans MK, Taylor H, Sale MM, Howard V, Carlson CS, Rotimi CN, Cushman M, Harris TB, Reiner AP, Cupples LA, North KE, Fox CS. Genome-wide association of body fat distribution in African ancestry populations suggests new loci. PLoS Genet. 2013;9(8):e1003681. doi: 10.1371/journal.pgen.1003681. Epub 2013 Aug 15.

  PMID: 23966867 DERIVED

• Arnett DK, Meyers KJ, Devereux RB, Tiwari HK, Gu CC, Vaughan LK, Perry RT, Patki A, Claas SA, Sun YV, Broeckel U, Kardia SL. Genetic variation in NCAM1 contributes to left ventricular wall thickness in hypertensive families. Circ Res. 2011 Feb 4;108(3):279-83. doi: 10.1161/CIRCRESAHA.110.239210. Epub 2011 Jan 6.

  PMID: 21212386 DERIVED

• Arnett DK, Devereux RB, Rao DC, Li N, Tang W, Kraemer R, Claas SA, Leon JM, Broeckel U. Novel genetic variants contributing to left ventricular hypertrophy: the HyperGEN study. J Hypertens. 2009 Aug;27(8):1585-93. doi: 10.1097/HJH.0b013e32832be612.

  PMID: 19593212 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Tissue suitable for DNA extraction

MeSH Terms

Conditions

Cardiovascular Diseases; Heart Diseases; Hypertension

Condition Hierarchy (Ancestors)

Vascular Diseases

Study Officials

• Donna Arnett

  University of Alabama at Birmingham

  PRINCIPAL INVESTIGATOR

• John Eckfeldt

  University of Minnesota

  PRINCIPAL INVESTIGATOR

• R.Curtis Ellison

  Boston University

  PRINCIPAL INVESTIGATOR

• Steven Hunt

  University of Utah

  PRINCIPAL INVESTIGATOR

• Jean-Marc Lalouel

  University of Utah

  PRINCIPAL INVESTIGATOR

• Cora Lewis

  University of Alabama at Birmingham

  PRINCIPAL INVESTIGATOR

• Kari North

  University of North Carolina

  PRINCIPAL INVESTIGATOR

• James Pankow

  University of Minnesota

  PRINCIPAL INVESTIGATOR

• Dabeeru Rao

  Washington University School of Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: FAMILY BASED
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 25, 2000
• First Posted: May 26, 2000
• Study Start: September 1, 1995
• Primary Completion: August 1, 2008
• Study Completion: August 1, 2008
• Last Updated: October 8, 2015

Record last verified: 2012-06