NCT00005208

Brief Summary

To elucidate the role of an imbalance in vasodilator prostacyclin (PGI2) and vasoconstrictor thromboxane (TxA2) in pregnancy-induced hypertension

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Sep 1987

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 1987

Completed
4.8 years until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 1992

Completed
7.9 years until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
Last Updated

February 29, 2016

Status Verified

May 1, 2000

First QC Date

May 25, 2000

Last Update Submit

February 26, 2016

Conditions

Cardiovascular DiseasesHeart DiseasesHypertensionPregnancy Toxemias

Eligibility Criteria

AgeUp to 100 Years
Sexmale
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (8)

  • Myatt L, Brewer AS, Brockman DE. The comparative effects of big endothelin-1, endothelin-1, and endothelin-3 in the human fetal-placental circulation. Am J Obstet Gynecol. 1992 Dec;167(6):1651-6. doi: 10.1016/0002-9378(92)91756-z.

    PMID: 1471681BACKGROUND

  • Myatt L. Control of vascular resistance in the human placenta. Placenta. 1992 Jul-Aug;13(4):329-41. doi: 10.1016/0143-4004(92)90057-z. No abstract available.

    PMID: 1438081BACKGROUND

  • Eis AW, Mitchell MD, Myatt L. Endothelin transfer and endothelin effects on water transfer in human fetal membranes. Obstet Gynecol. 1992 Mar;79(3):411-5. doi: 10.1097/00006250-199203000-00017.

    PMID: 1738524BACKGROUND

  • Myatt L, Brewer AS, Langdon G, Brockman DE. Attenuation of the vasoconstrictor effects of thromboxane and endothelin by nitric oxide in the human fetal-placental circulation. Am J Obstet Gynecol. 1992 Jan;166(1 Pt 1):224-30. doi: 10.1016/0002-9378(92)91863-6.

    PMID: 1733199BACKGROUND

  • Myatt L, Langdon G, Brewer AS, Brockman DE. Endothelin-1-induced vasoconstriction is not mediated by thromboxane release and action in the human fetal-placental circulation. Am J Obstet Gynecol. 1991 Dec;165(6 Pt 1):1717-22. doi: 10.1016/0002-9378(91)90021-i.

    PMID: 1750466BACKGROUND

  • Jacobson RL, Brewer A, Eis A, Siddiqi TA, Myatt L. Transfer of aspirin across the perfused human placental cotyledon. Am J Obstet Gynecol. 1991 Oct;165(4 Pt 1):939-44. doi: 10.1016/0002-9378(91)90444-v.

    PMID: 1951559BACKGROUND

  • Myatt L, Brewer A, Brockman DE. The action of nitric oxide in the perfused human fetal-placental circulation. Am J Obstet Gynecol. 1991 Feb;164(2):687-92. doi: 10.1016/s0002-9378(11)80047-5.

    PMID: 1899534BACKGROUND

  • Myatt L, Brockman DE, Langdon G, Pollock JS. Constitutive calcium-dependent isoform of nitric oxide synthase in the human placental villous vascular tree. Placenta. 1993 Jul-Aug;14(4):373-83. doi: 10.1016/s0143-4004(05)80459-x.

    PMID: 7504255BACKGROUND

MeSH Terms

Conditions

Cardiovascular DiseasesHeart DiseasesHypertensionPre-Eclampsia

Condition Hierarchy (Ancestors)

Vascular DiseasesHypertension, Pregnancy-InducedPregnancy ComplicationsFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital Diseases

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

September 1, 1987

Study Completion

July 1, 1992

Last Updated

February 29, 2016

Record last verified: 2000-05