Cardiovascular Risk Profile Among Mexican-Americans

NCT00005187 | Completed

• 2 other identifiers: 1065R01HL034823
• Study Type: observational
• Target: 2,058
• Locations: 0 countries
• Sites: N/A

Brief Summary

To characterize the epidemiology and genetics of apolipoproteins A-I, A-II, B, C-II, C-III, and E in a population of Mexican-Americans in Starr County, Texas.

Conditions

Cardiovascular Diseases; Atherosclerosis; Heart Diseases

Eligibility Criteria

• Age: 7 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Mexican American residents of Starr County, Texas.

Participation in prior survey of Starr County, Texas where 1,004 representative individuals of the population aged 15 and older were selected. The community was first mapped and random blocks selected. All individuals in households on selected blocks were enumerated and then 1 age eligible individual from each household was selected for a complete physical evaluation. From these, 250 individuals were identified as probands and their, primarily, first degree relatives were selected for the same examination. 1,254 individuals were seen in this phase. These individuals became eligible for the more complete profiling of apolipoproteins funded by the referenced grant.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• The University of Texas Health Science Center, Houston: lead
• National Heart, Lung, and Blood Institute (NHLBI): collaborator

Related Publications (13)

• Reichley KB, Mueller WH, Hanis CL, Joos SK, Tulloch BR, Barton S, Schull WJ. Centralized obesity and cardiovascular disease risk in Mexican Americans. Am J Epidemiol. 1987 Mar;125(3):373-86. doi: 10.1093/oxfordjournals.aje.a114544.

  PMID: 3812446 BACKGROUND

• Mueller WH, Wear ML, Hanis CL, Barton SA, Schull WJ. Body circumferences as alternatives to skinfold measurements of body fat distribution in Mexican-Americans. Int J Obes. 1987;11(4):309-18.

  PMID: 3667064 BACKGROUND

• Chakraborty R, Hanis CL. Non-random sampling in human genetics: estimation of familial correlations, model testing, and interpretation. Stat Med. 1987 Jul-Aug;6(5):629-46. doi: 10.1002/sim.4780060511.

  PMID: 3659672 BACKGROUND

• Schull WJ and Hanis CL: Genetic Versus Environmental Influences on Disease: Perspectives from Obesity. In: Cruickshank K, Beevers DG (Eds), Ethnic Factors in Health and Disease. Hertfordshire, England: John Wright Medical Publishers. 1989.

  BACKGROUND

• Hanis CL and Schull WJ: Diabetes Among Mexican-Americans in Starr County, Texas: Definition and Disease. In: Diabetes Among Mexican-Americans in Texas. Austin, Texas: The Texas Diabetes Council, 1987

  BACKGROUND

• Boerwinkle E, Hanis CL, Chan L. A unique length polymorphism in the signal peptide region of the apolipoprotein B gene in Mexican-Americans. Nucleic Acids Res. 1990 Dec 11;18(23):7193. doi: 10.1093/nar/18.23.7193.

  PMID: 2263508 BACKGROUND

• Hanis CL, Bertin TK. Identification of an insulin receptor exon 8 NsiI polymorphism using the polymerase chain reaction. Nucleic Acids Res. 1990 Oct 11;18(19):5923. doi: 10.1093/nar/18.19.5923. No abstract available.

  PMID: 1977145 BACKGROUND

• Boerwinkle E, Chen SH, Visvikis S, Hanis CL, Siest G, Chan L. Signal peptide-length variation in human apolipoprotein B gene. Molecular characteristics and association with plasma glucose levels. Diabetes. 1991 Nov;40(11):1539-44. doi: 10.2337/diab.40.11.1539.

  PMID: 1936612 BACKGROUND

• Hanis CL, Douglas TC, Hewett-Emmett D. Apolipoprotein A-IV protein polymorphism: frequency and effects on lipids, lipoproteins, and apolipoproteins among Mexican-Americans in Starr County, Texas. Hum Genet. 1991 Jan;86(3):323-5. doi: 10.1007/BF00202422.

  PMID: 1997391 BACKGROUND

• Hanis CL, Hewett-Emmett D, Douglas TC, Schull WJ. Lipoprotein and apolipoprotein levels among Mexican-Americans in Starr County, Texas. Arterioscler Thromb. 1991 Jan-Feb;11(1):123-9. doi: 10.1161/01.atv.11.1.123.

  PMID: 1987989 BACKGROUND

• Schull WJ, Hanis CL. Genetics and public health in the 1990s. Annu Rev Public Health. 1990;11:105-25. doi: 10.1146/annurev.pu.11.050190.000541. No abstract available.

  PMID: 2191654 BACKGROUND

• Hanis CL, Hewett-Emmett D, Kubrusly LF, Maklad MN, Douglas TC, Mueller WH, Barton SA, Yoshimaru H, Kubrusly DB, Gonzalez R, et al. An ultrasound survey of gallbladder disease among Mexican Americans in Starr County, Texas: frequencies and risk factors. Ethn Dis. 1993 Winter;3(1):32-43.

  PMID: 8508103 BACKGROUND

• Hanis CL, Hewett-Emmett D, Douglas TC, Bertin TK, Schull WJ. Effects of the apolipoprotein E polymorphism on levels of lipids, lipoproteins, and apolipoproteins among Mexican-Americans in Starr County, Texas. Arterioscler Thromb. 1991 Mar-Apr;11(2):362-70. doi: 10.1161/01.atv.11.2.362.

  PMID: 1998654 BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

Plasma, buffy coats and red cell aliquots

MeSH Terms

Conditions

Cardiovascular Diseases; Atherosclerosis; Heart Diseases

Condition Hierarchy (Ancestors)

Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: May 25, 2000
• First Posted: May 26, 2000
• Study Start: April 1, 1986
• Primary Completion: March 1, 1992
• Study Completion: March 1, 1992
• Last Updated: April 18, 2019

Record last verified: 2019-04