NCT00005134

Brief Summary

To determine morbidity and mortality from cardiovascular disease among American Indians and to compare cardiovascular disease risk factor levels among Indian groups living in different geographic areas.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Sep 1988

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 1988

Completed
11.7 years until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
5.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2005

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2005

Completed
Last Updated

July 29, 2016

Status Verified

May 1, 2009

Enrollment Period

17.3 years

First QC Date

May 25, 2000

Last Update Submit

July 28, 2016

Conditions

Cardiovascular DiseasesHeart DiseasesAtherosclerosisAsthmaCarotid Artery DiseasesCoronary DiseaseHypercholesterolemiaHypertensionDiabetes MellitusObesity

Eligibility Criteria

Age45 Years - 74 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (6)

  • Please refer to the Strong Heart Study Home Page for complete bibliography. http://strongheart.ouhsc.edu/

    BACKGROUND

  • Fretts AM, Jensen PN, Sitlani CM, Hoofnagle A, Lidgard B, Umans JG, Siscovick DS, King IB, Howard BV, Cole SA, Lemaitre RN. Circulating Sphingolipids and All-Cause Mortality: The Strong Heart Family Study. J Am Heart Assoc. 2024 Jul 2;13(13):e032536. doi: 10.1161/JAHA.123.032536. Epub 2024 Jun 21.

    PMID: 38904223DERIVED

  • Fretts AM, Jensen PN, Hoofnagle A, McKnight B, Howard BV, Umans J, Yu C, Sitlani C, Siscovick DS, King IB, Sotoodehnia N, Lemaitre RN. Plasma Ceramide Species Are Associated with Diabetes Risk in Participants of the Strong Heart Study. J Nutr. 2020 May 1;150(5):1214-1222. doi: 10.1093/jn/nxz259.

    PMID: 31665380DERIVED

  • Mancusi C, de Simone G, Best LG, Wang W, Zhang Y, Roman MJ, Lee ET, Howard BV, Devereux RB. Myocardial mechano-energetic efficiency and insulin resistance in non-diabetic members of the Strong Heart Study cohort. Cardiovasc Diabetol. 2019 Apr 30;18(1):56. doi: 10.1186/s12933-019-0862-9.

    PMID: 31039789DERIVED

  • Lemaitre RN, Yu C, Hoofnagle A, Hari N, Jensen PN, Fretts AM, Umans JG, Howard BV, Sitlani CM, Siscovick DS, King IB, Sotoodehnia N, McKnight B. Circulating Sphingolipids, Insulin, HOMA-IR, and HOMA-B: The Strong Heart Family Study. Diabetes. 2018 Aug;67(8):1663-1672. doi: 10.2337/db17-1449. Epub 2018 Mar 27.

    PMID: 29588286DERIVED

  • de Simone G, Wang W, Best LG, Yeh F, Izzo R, Mancusi C, Roman MJ, Lee ET, Howard BV, Devereux RB. Target organ damage and incident type 2 diabetes mellitus: the Strong Heart Study. Cardiovasc Diabetol. 2017 May 12;16(1):64. doi: 10.1186/s12933-017-0542-6.

    PMID: 28499385DERIVED

Related Links

MeSH Terms

Conditions

Cardiovascular DiseasesHeart DiseasesAtherosclerosisAsthmaCarotid Artery DiseasesCoronary DiseaseHypercholesterolemiaHypertensionDiabetes MellitusObesity

Condition Hierarchy (Ancestors)

ArteriosclerosisArterial Occlusive DiseasesVascular DiseasesBronchial DiseasesRespiratory Tract DiseasesLung Diseases, ObstructiveLung DiseasesRespiratory HypersensitivityHypersensitivity, ImmediateHypersensitivityImmune System DiseasesCerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesMyocardial IschemiaHyperlipidemiasDyslipidemiasLipid Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesGlucose Metabolism DisordersEndocrine System DiseasesOverweightOvernutritionNutrition DisordersBody WeightSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Lyle Best

    U.S. P.H.S. Aberdeen Area Indian Health Services

  • Richard Devereux

    Weill Medical College of Cornell University

  • Barbara Howard

    Medlantic Research Foundation

  • Elisa Lee

    University of Oklahoma

  • Jean MacCluer

    Southwest Foundation for Biomedical Research

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

September 1, 1988

Primary Completion

December 1, 2005

Study Completion

December 1, 2005

Last Updated

July 29, 2016

Record last verified: 2009-05