NCT00000486

Brief Summary

To compare the efficacy of medical or surgical (coronary artery bypass graft) therapy with regard to survival and quality of life in patients with unstable angina and requisite coronary anatomy as defined by angiography.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Jan 1972

Longer than P75 for phase_3

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 1972

Completed
8 years until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 1980

Completed
19.8 years until next milestone

First Submitted

Initial submission to the registry

October 27, 1999

Completed
1 day until next milestone

First Posted

Study publicly available on registry

October 28, 1999

Completed
Last Updated

November 26, 2013

Status Verified

January 1, 2000

First QC Date

October 27, 1999

Last Update Submit

November 25, 2013

Conditions

Angina, UnstableCardiovascular DiseasesCoronary DiseaseHeart DiseasesMyocardial Ischemia

Interventions

coronary artery bypassPROCEDURE

Eligibility Criteria

Age21 Years - 65 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Men and women, ages 21 to 65. Angina pectoris (class III or class IV) at rest or with minimal exercise.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (3)

  • Unstable angina pectoris: national cooperative study group to compare medical and surgical therapy. I. Report of protocol and patient population. Am J Cardiol. 1976 May;37(6):896-902. doi: 10.1016/0002-9149(76)90116-8.

    PMID: 1266755BACKGROUND

  • Unstable angina pectoris: national cooperative study group to compare surgical and medical therapy. III. Results in patients with S-T segment elevation during pain. Am J Cardiol. 1980 Apr;45(4):819-24. doi: 10.1016/0002-9149(80)90127-7. No abstract available.

    PMID: 6965816BACKGROUND

  • Russell RO Jr, Wayne JB, Kronefeld J, Charles ED, Oberman A, Kouchoukos NT, White C, Rogers W, Mantle JA, Rackley CE. Surgical versus medical therapy for treatment of unstable angina: changes in work status and family income. Am J Cardiol. 1980 Jan;45(1):134-40. doi: 10.1016/0002-9149(80)90231-3. No abstract available.

    PMID: 6965333BACKGROUND

MeSH Terms

Conditions

Angina, UnstableCardiovascular DiseasesCoronary DiseaseHeart DiseasesMyocardial Ischemia

Interventions

Coronary Artery Bypass

Condition Hierarchy (Ancestors)

Angina PectorisVascular DiseasesChest PainPainNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Myocardial RevascularizationCardiac Surgical ProceduresCardiovascular Surgical ProceduresSurgical Procedures, OperativeVascular GraftingVascular Surgical ProceduresThoracic Surgical Procedures

Study Officials

  • Lewis Becker

    Johns Hopkins University

  • Adolph Hutter

    Massachusetts General Hospital

  • Leon Resnekov

    University of Chicago

  • Richard Russell

    University of Alabama at Birmingham

  • John Schroeder

    Stanford University

  • Andrew Wallace

    Duke University

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Purpose
TREATMENT
Sponsor Type
NIH

Study Record Dates

First Submitted

October 27, 1999

First Posted

October 28, 1999

Study Start

January 1, 1972

Study Completion

January 1, 1980

Last Updated

November 26, 2013

Record last verified: 2000-01