Hereditary Deficits in Auditory Processing Leading to Language Impairment

NCT00004570 | Terminated

• 2 other identifiers: 00007300-DC-0073
• Study Type: observational
• Target: 875
• Locations: 1 country
• Sites: 1

Brief Summary

Some children with certain language disorders may not properly process the sounds they hear, resulting in language impairments. The purpose of this study is to determine if deficits in auditory temporal processing the way the brain analyzes the timing and patterns of sounds are an inherited trait. Families with auditory temporal processing deficits are sought in order to identify the genes responsible for auditory temporal processing deficits. Children and adults with a diagnosis or history of language impairment in the family and their family members both affected and non-affected are eligible for this two-part study. In Part 1, participants undergo a series of language tests and listening tests to measure various characteristics of how they perceive sound. In Part 2, they are interviewed about language disorders, learning disabilities, and other medical problems of family members. This information is used to construct a pedigree (family tree diagram) showing the pattern of inheritance of family traits. Study subjects whose pedigree indicates that language disorders may be hereditary in their family will provide either a small blood sample (1 to 2 tablespoons) or a tissue specimen obtained from a cheek swab (rubbing the inside of the cheek with a small brush or cotton swabs). The sample will be used to isolate DNA for genetic analysis.

Conditions

Auditory Perceptual Disorder; Language Delay; Language Disorder

Keywords

Temporal Processing; Language Impairment; Linkage Analysis; Inheritance; Language Delay; Healthy; Auditory Temporal Processing Disorder; Speech Impediment

Eligibility Criteria

• Age: 6 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• years of age
• Native English speaker, with English as the first language
• Phase 1 Same sex twins (MZ or DZ) and both willing and able to participate in test procedures.
• Phase 2 Score in the top or bottom 10th percentile on tests of auditory processing or are a first-degree relative of someone who scores in the top or bottom 10th percentile and are willing and able to participate in the test procedures.

You may not qualify if:

• Hearing loss, defined as air conduction pure tone thresholds (250-8000 Hz) exceeding 20 dBHL; air-bone gaps, even in the presence of normal hearing sensitivity, exceeding 10 dBHL; and/or abnormal tympanometry.
• History of chronic (fluid in middle ear for more than 4 months) or recurrent otitis media (more than 4 episodes of acute otitis media in one year)
• History of ear surgery.
• History or diagnosis of a central nervous system disorder, including but not limited to:
• Intracranial tumors
• Cerebrovascular disease
• Degenerative CNS disorder
• CNS trauma
• Encephalitis
• Meningitis
• Auditory neuropathy
• Attention deficit hyperactivity disorder (ADHD)
• Attention deficit disorder (ADD)
• Currently taking medications capable of altering CNS function (e.g. antidepressants, anxiolytics, or a psychostimulant drugs such as ritalin).
• History of treatment with ototoxic medications that may affect ultrahigh frequency hearing (e.g. cisplatin, aminoglycoside antibiotics).

Sponsors & Collaborators

• National Institute on Deafness and Other Communication Disorders (NIDCD): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Bishop DV. Autism, Asperger's syndrome and semantic-pragmatic disorder: where are the boundaries? Br J Disord Commun. 1989 Aug;24(2):107-21. doi: 10.3109/13682828909011951.

  PMID: 2690915 BACKGROUND

• Bishop DV. Is specific language impairment a valid diagnostic category? Genetic and psycholinguistic evidence. Philos Trans R Soc Lond B Biol Sci. 1994 Oct 29;346(1315):105-11. doi: 10.1098/rstb.1994.0134.

  PMID: 7886145 BACKGROUND

• Tomblin JB, Records NL, Buckwalter P, Zhang X, Smith E, O'Brien M. Prevalence of specific language impairment in kindergarten children. J Speech Lang Hear Res. 1997 Dec;40(6):1245-60. doi: 10.1044/jslhr.4006.1245.

  PMID: 9430746 BACKGROUND

MeSH Terms

Conditions

Auditory Perceptual Disorders; Language Development Disorders; Language Disorders; Speech Disorders

Condition Hierarchy (Ancestors)

Auditory Diseases, Central; Retrocochlear Diseases; Ear Diseases; Otorhinolaryngologic Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Perceptual Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Communication Disorders

Study Officials

• Carmen C Brewer, Ph.D.

  National Institute on Deafness and Other Communication Disorders (NIDCD)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 14, 2000
• First Posted: February 15, 2000
• Study Start: January 31, 1999
• Study Completion: September 18, 2018
• Last Updated: September 20, 2018

Record last verified: 2018-09-18

Locations

US (1)