MR Scanning of Very Young Children With Severe Developmental Disorders

NCT00156221 | Completed

• 1 other identifier: METC UMC Utrecht 99/184
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

The specific is to study the MR morphologic and spectroscopic brain correlates and predictors of development in children with severe developmental disorders (autistic spectrum disorders and/or mental retardation and/or language disorders). Given the frequently observed association of autism with known medical conditions, particularly in cases with comorbid mental retardation and in cases with atypical autism (Rutter et al., 1994; Gillberg, 1995), children with suspected autism or related developmental disorders will be asked to participate in an extensive state of the art laboratory work-up which includes T1 and T2 weighted MRI of the brain. MRI data will be analyzed both qualitatively, looking for focal abnormalities and degree of myelination, and quantitatively, measuring volumes of total brain, cerebellum, ventricles and grey and white matter. For research purposes, the work-up will be supplied with proton Magnetic Resonance Spectroscopy (MRS) of the brain. This data set provides the opportunity to chart brain-behavior relationships in young children with suspected autism and related PDD cross-sectionally.

Conditions

Autism; Mental Retardation; Language Disorder

Keywords

Autism; MRI; Developmental Disorders

Eligibility Criteria

• Age: 18 Months - 7 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• Age 18 months to 7 years
• Diagnosis of autism spectrum disorder, a language disorder or mental retardation

You may not qualify if:

• Significant motor or sensory impairment
• Major physical abnormalities
• History of serious head injury
• Identifiable neurologic disorder
• Metal implants
• Contraindication for MRI

Sponsors & Collaborators

• UMC Utrecht: lead
• Netherlands Organisation for Scientific Research: collaborator
• The Dutch Brain Foundation: collaborator

Study Sites (1)

UMC Utrecht

Utrecht, 3508 GA, Netherlands

Location

MeSH Terms

Conditions

Autistic Disorder; Intellectual Disability; Language Disorders; Developmental Disabilities

Condition Hierarchy (Ancestors)

Autism Spectrum Disorder; Child Development Disorders, Pervasive; Neurodevelopmental Disorders; Mental Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Communication Disorders

Study Officials

• Herman van Engeland, PhD, MD

  UMC Utrecht

  STUDY CHAIR

• Mijke Zeegers, Msc

  UMC Utrecht

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: NATURAL HISTORY
• Time Perspective: OTHER
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: September 8, 2005
• First Posted: September 12, 2005
• Study Start: September 1, 2000
• Study Completion: September 1, 2005
• Last Updated: September 12, 2005

Record last verified: 2005-09

Locations

NL (1)