NCT00004345

Brief Summary

OBJECTIVES: I. Examine the concentration of docosahexanoic acid (DHA) and other n-3 fatty acids in plasma, erythrocyte, and adipose tissue in patients with various forms of retinitis pigmentosa and Usher syndrome. II. Determine the synthesis and catabolism of DHA from linolenic acid in these patients. III. Determine the synthesis, absorption, and catabolism of DHA under different dietary conditions in these patients.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
100

participants targeted

Target at P50-P75 for all trials

Geographic Reach
1 country

1 active site

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 1999

Completed
17 days until next milestone

First Submitted

Initial submission to the registry

October 18, 1999

Completed
1 day until next milestone

First Posted

Study publicly available on registry

October 19, 1999

Completed
Last Updated

June 24, 2005

Status Verified

July 1, 2002

First QC Date

October 18, 1999

Last Update Submit

June 23, 2005

Conditions

Usher SyndromeRetinitis Pigmentosa

Keywords

Usher syndromeophthalmologic disordersrare diseaseretinitis pigmentosa

Eligibility Criteria

Age0 Years+
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
PROTOCOL ENTRY CRITERIA: * Retinitis pigmentosa, including: Usher syndrome (types I and II) Simplex * The following inheritance patterns eligible: X-linked recessive; Autosomal dominant; Autosomal recessive

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (1)

Oregon Health Sciences University

Portland, Oregon, 97201-3098, United States

Location

Related Publications (1)

  • Schwartz SG, Wang X, Chavis P, Kuriyan AE, Abariga SA. Vitamin A and fish oils for preventing the progression of retinitis pigmentosa. Cochrane Database Syst Rev. 2020 Jun 18;6(6):CD008428. doi: 10.1002/14651858.CD008428.pub3.

    PMID: 32573764DERIVED

MeSH Terms

Conditions

Usher SyndromesRetinitis PigmentosaRare Diseases

Condition Hierarchy (Ancestors)

Deaf-Blind DisordersDeafnessHearing LossHearing DisordersEar DiseasesOtorhinolaryngologic DiseasesHearing Loss, SensorineuralSensation DisordersNeurologic ManifestationsNervous System DiseasesBlindnessVision DisordersRetinal DystrophiesRetinal DegenerationRetinal DiseasesEye DiseasesAbnormalities, MultipleCongenital AbnormalitiesCongenital, Hereditary, and Neonatal Diseases and AbnormalitiesEye Diseases, HereditaryGenetic Diseases, InbornSigns and SymptomsPathological Conditions, Signs and SymptomsDisease AttributesPathologic Processes

Study Officials

  • William Connor

    Oregon Health and Science University

    STUDY CHAIR

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

October 18, 1999

First Posted

October 19, 1999

Study Start

October 1, 1999

Last Updated

June 24, 2005

Record last verified: 2002-07

Locations

US(1)