Fludarabine With or Without Cyclophosphamide in Treating Patients With Chronic Lymphocytic Leukemia
Phase III Randomized Trial of Fludarabine and Cyclophosphamide Versus Fludarabine for Previously Untreated Chronic Lymphocytic Leukemia
4 other identifiers
interventional
280
4 countries
218
Brief Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. It is not yet known whether combining cyclophosphamide with fludarabine is more effective than fludarabine alone in treating chronic lymphocytic leukemia. PURPOSE: Randomized phase III trial to study the effectiveness of fludarabine with or without cyclophosphamide in treating patients who have chronic lymphocytic leukemia that has not been treated previously.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for phase_3 leukemia
218 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 1, 1999
CompletedStudy Start
First participant enrolled
March 9, 2000
CompletedFirst Posted
Study publicly available on registry
January 27, 2003
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2005
CompletedJune 18, 2023
June 1, 2023
5.7 years
November 1, 1999
June 14, 2023
Conditions
Keywords
Interventions
Eligibility Criteria
Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.
Sponsors & Collaborators
- Eastern Cooperative Oncology Grouplead
- National Cancer Institute (NCI)collaborator
- Cancer and Leukemia Group Bcollaborator
- SWOG Cancer Research Networkcollaborator
Study Sites (218)
Northeast Alabama Regional Medical Center
Anniston, Alabama, 36207, United States
University of Alabama at Birmingham Comprehensive Cancer Center
Birmingham, Alabama, 35294-3300, United States
MBCCOP - Gulf Coast
Mobile, Alabama, 36688, United States
CCOP - Western Regional, Arizona
Phoenix, Arizona, 85006-2726, United States
Veterans Affairs Medical Center - Phoenix (Carl T. Hayden)
Phoenix, Arizona, 85012, United States
Veterans Affairs Medical Center - Tucson
Tucson, Arizona, 85723, United States
Arizona Cancer Center at University of Arizona Health Sciences Center
Tucson, Arizona, 85724, United States
University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205, United States
Veterans Affairs Medical Center - Little Rock (McClellan)
Little Rock, Arkansas, 72205, United States
City of Hope Comprehensive Cancer Center
Duarte, California, 91010-0269, United States
Rebecca and John Moores UCSD Cancer Center
La Jolla, California, 92093-0658, United States
USC/Norris Comprehensive Cancer Center and Hospital
Los Angeles, California, 90033, United States
Cedars-Sinai Comprehensive Cancer Center at Cedars-Sinai Medical Center
Los Angeles, California, 90048, United States
Jonsson Comprehensive Cancer Center, UCLA
Los Angeles, California, 90095-1781, United States
Veterans Affairs Outpatient Clinic - Martinez
Martinez, California, 94553, United States
CCOP - Bay Area Tumor Institute
Oakland, California, 94609-3305, United States
Chao Family Comprehensive Cancer Center at University of California Irvine Cancer Center
Orange, California, 92868, United States
University of California Davis Cancer Center
Sacramento, California, 95817, United States
Veterans Affairs Medical Center - San Diego
San Diego, California, 92161, United States
Veterans Affairs Medical Center - San Francisco
San Francisco, California, 94121, United States
CCOP - Santa Rosa Memorial Hospital
Santa Rosa, California, 95403, United States
David Grant Medical Center
Travis Air Force Base, California, 94535, United States
University of Colorado Cancer Center at University of Colorado Health Sciences Center
Aurora, Colorado, 80010, United States
Medical Center of Aurora - South Campus
Aurora, Colorado, 80012-0000, United States
Boulder Community Hospital
Boulder, Colorado, 80301-9019, United States
Penrose Cancer Center
Colorado Springs, Colorado, 80933, United States
Porter Adventist Hospital
Denver, Colorado, 80210, United States
St. Joseph Hospital
Denver, Colorado, 80218-1191, United States
Presbyterian-St Luke's Medical Center
Denver, Colorado, 80218, United States
Rocky Mountain Cancer Centers - Rose
Denver, Colorado, 80220, United States
CCOP - Colorado Cancer Research Program, Incorporated
Denver, Colorado, 80224, United States
Swedish Medical Center
Englewood, Colorado, 80110, United States
Sky Ridge Medical Center
Lone Tree, Colorado, 80124, United States
Longmont United Hospital
Longmont, Colorado, 80501, United States
St. Mary-Corwin Regional Medical Center
Pueblo, Colorado, 81004, United States
Rocky Mountain Cancer Centers
Thornton, Colorado, 80260, United States
CCOP - Christiana Care Health Services
Newark, Delaware, 19713, United States
Lombardi Cancer Center at Georgetown University Medical Center
Washington D.C., District of Columbia, 20007, United States
MBCCOP - Howard University Cancer Center
Washington D.C., District of Columbia, 20060, United States
Walter Reed Army Medical Center
Washington D.C., District of Columbia, 20307-5000, United States
Veterans Affairs Medical Center - Washington, DC
Washington D.C., District of Columbia, 20422, United States
Broward General Medical Center
Fort Lauderdale, Florida, 33316, United States
Memorial Regional Hospital Comprehensive Cancer Center
Hollywood, Florida, 33021, United States
CCOP - Mount Sinai Medical Center
Miami Beach, Florida, 33140, United States
Florida Hospital Cancer Institute
Orlando, Florida, 32804, United States
H. Lee Moffitt Cancer Center and Research Institute
Tampa, Florida, 33612-9497, United States
Palm Beach Cancer Institute
West Palm Beach, Florida, 33401, United States
Winship Cancer Institute of Emory University
Atlanta, Georgia, 30322, United States
CCOP - Atlanta Regional
Atlanta, Georgia, 30342-1701, United States
Veterans Affairs Medical Center - Atlanta (Decatur)
Decatur, Georgia, 30033, United States
MBCCOP - Hawaii
Honolulu, Hawaii, 96813, United States
Veterans Affairs Medical Center - Lakeside Chicago
Chicago, Illinois, 60611-4494, United States
Robert H. Lurie Comprehensive Cancer Center at Northwestern University
Chicago, Illinois, 60611, United States
MBCCOP - University of Illinois at Chicago
Chicago, Illinois, 60612, United States
Veterans Affairs Medical Center - Chicago (Westside Hospital)
Chicago, Illinois, 60612, United States
University of Chicago Cancer Research Center
Chicago, Illinois, 60637-1470, United States
Louis A. Weiss Memorial Hospital
Chicago, Illinois, 60640, United States
CCOP - Central Illinois
Decatur, Illinois, 62526, United States
CCOP - Evanston
Evanston, Illinois, 60201, United States
Veterans Affairs Medical Center - Hines (Hines Junior VA Hospital)
Hines, Illinois, 60141, United States
Cardinal Bernardin Cancer Center at Loyola University Medical Center
Maywood, Illinois, 60153-5500, United States
CCOP - Illinois Oncology Research Association
Peoria, Illinois, 61602, United States
West Suburban Center for Cancer Care
River Forest, Illinois, 60305, United States
Saint Anthony Medical Center
Rockford, Illinois, 61108, United States
CCOP - Carle Cancer Center
Urbana, Illinois, 61801, United States
Fort Wayne Medical Oncology and Hematology, Incorporated
Fort Wayne, Indiana, 46885-5099, United States
CCOP - Northern Indiana CR Consortium
South Bend, Indiana, 46601, United States
Hematology Oncology Associates of the Quad Cities
Bettendorf, Iowa, 52722, United States
CCOP - Cedar Rapids Oncology Project
Cedar Rapids, Iowa, 52403-1206, United States
Genesis Medical Center
Davenport, Iowa, 52804, United States
CCOP - Iowa Oncology Research Association
Des Moines, Iowa, 50309-1016, United States
Holden Comprehensive Cancer Center at University of Iowa
Iowa City, Iowa, 52242-1009, United States
Kansas Cancer Institute at the University of Kansas Medical Center
Kansas City, Kansas, 66160-7353, United States
CCOP - Wichita
Wichita, Kansas, 67214-3882, United States
Veterans Affairs Medical Center - Wichita
Wichita, Kansas, 67218, United States
Veterans Affairs Medical Center - Lexington
Lexington, Kentucky, 40502-2236, United States
Markey Cancer Center at University of Kentucky Chandler Medical Center
Lexington, Kentucky, 40536-0084, United States
Baptist Hospital East - Louisville
Louisville, Kentucky, 40207, United States
MBCCOP - LSU Health Sciences Center
New Orleans, Louisiana, 70112, United States
Tulane University School of Medicine
New Orleans, Louisiana, 70112, United States
Veterans Affairs Medical Center - New Orleans
New Orleans, Louisiana, 70112, United States
CCOP - Ochsner
New Orleans, Louisiana, 70121, United States
Louisiana State University Health Sciences Center - Shreveport
Shreveport, Louisiana, 71130-3932, United States
Veterans Affairs Medical Center - Shreveport
Shreveport, Louisiana, 71130, United States
Marlene and Stewart Greenebaum Cancer Center, University of Maryland
Baltimore, Maryland, 21201, United States
Veterans Affairs Medical Center - Baltimore
Baltimore, Maryland, 21201, United States
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, Maryland, 21231, United States
Tufts - New England Medical Center
Boston, Massachusetts, 02111, United States
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
Boston, Massachusetts, 02115, United States
Cancer Research Center at Boston Medical Center
Boston, Massachusetts, 02118, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
University of Massachusetts Memorial Medical Center - University Campus
Worcester, Massachusetts, 01655, United States
Veterans Affairs Medical Center - Ann Arbor
Ann Arbor, Michigan, 48105, United States
CCOP - Michigan Cancer Research Consortium
Ann Arbor, Michigan, 48106, United States
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, 48109-0912, United States
Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, 48201-1379, United States
Veterans Affairs Medical Center - Detroit
Detroit, Michigan, 48201-1932, United States
Josephine Ford Cancer Center at Henry Ford Hospital
Detroit, Michigan, 48202, United States
CCOP - Grand Rapids
Grand Rapids, Michigan, 49503, United States
CCOP - Kalamazoo
Kalamazoo, Michigan, 49007-3731, United States
CCOP - Beaumont
Royal Oak, Michigan, 48073-6769, United States
Lakeland Cancer Care Center at Lakeland Hospital - St. Joseph
Saint Joseph, Michigan, 49085, United States
Providence Cancer Institute at Providence Hospital
Southfield, Michigan, 48075, United States
Veterans Affairs Medical Center - Minneapolis
Minneapolis, Minnesota, 55417, United States
University of Minnesota Cancer Center
Minneapolis, Minnesota, 55455, United States
Mayo Clinic Cancer Center
Rochester, Minnesota, 55905, United States
CCOP - Metro-Minnesota
Saint Louis Park, Minnesota, 55416, United States
Veterans Affairs Medical Center - Biloxi
Biloxi, Mississippi, 39531-2410, United States
University of Mississippi Medical Center
Jackson, Mississippi, 39216-4505, United States
Veterans Affairs Medical Center - Jackson
Jackson, Mississippi, 39216, United States
Veterans Affairs Medical Center - Columbia (Truman Memorial)
Columbia, Missouri, 65201, United States
Ellis Fischel Cancer Center at University of Missouri - Columbia
Columbia, Missouri, 65203, United States
Veterans Affairs Medical Center - Kansas City
Kansas City, Missouri, 64128, United States
CCOP - Kansas City
Kansas City, Missouri, 64131, United States
CCOP - Cancer Research for the Ozarks
Springfield, Missouri, 65807, United States
Barnes-Jewish Hospital
St Louis, Missouri, 63110, United States
St. Louis University Hospital Cancer Center
St Louis, Missouri, 63110, United States
Missouri Baptist Cancer Center
St Louis, Missouri, 63131, United States
CCOP - St. Louis-Cape Girardeau
St Louis, Missouri, 63141, United States
CCOP - Montana Cancer Consortium
Billings, Montana, 59101, United States
UNMC Eppley Cancer Center at the University of Nebraska Medical Center
Omaha, Nebraska, 68198-7680, United States
CCOP - Southern Nevada Cancer Research Foundation
Las Vegas, Nevada, 89106, United States
Veterans Affairs Medical Center - Las Vegas
Las Vegas, Nevada, 89106, United States
Norris Cotton Cancer Center at Dartmouth Medical School
Lebanon, New Hampshire, 03756-0002, United States
Cooper University Hospital
Camden, New Jersey, 08103, United States
Veterans Affairs Medical Center - East Orange
East Orange, New Jersey, 07019, United States
Cancer Institute of New Jersey
New Brunswick, New Jersey, 08903, United States
Veterans Affairs Medical Center - Albuquerque
Albuquerque, New Mexico, 87108-5138, United States
MBCCOP - University of New Mexico HSC
Albuquerque, New Mexico, 87131, United States
Veterans Affairs Medical Center - Albany
Albany, New York, 12208, United States
Veterans Affairs Medical Center - Buffalo
Buffalo, New York, 14215, United States
Elmhurst Hospital Center
Elmhurst, New York, 11373, United States
Queens Cancer Center of Queens Hospital
Jamaica, New York, 11432, United States
CCOP - North Shore University Hospital
Manhasset, New York, 11030, United States
North Shore University Hospital
Manhasset, New York, 11030, United States
Memorial Sloan-Kettering Cancer Center
New York, New York, 10021, United States
New York Weill Cornell Cancer Center at Cornell University
New York, New York, 10021, United States
Mount Sinai Medical Center, NY
New York, New York, 10029, United States
Herbert Irving Comprehensive Cancer Center at Columbia University
New York, New York, 10032, United States
James P. Wilmot Cancer Center at University of Rochester Medical Center
Rochester, New York, 14642, United States
University Hospital at State University of New York - Upstate Medical University
Syracuse, New York, 13210, United States
Veterans Affairs Medical Center - Syracuse
Syracuse, New York, 13210, United States
CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
Syracuse, New York, 13217, United States
Albert Einstein Clinical Cancer Center
The Bronx, New York, 10461, United States
Veterans Affairs Medical Center - Asheville
Asheville, North Carolina, 28805, United States
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
Chapel Hill, North Carolina, 27599-7295, United States
NorthEast Oncology Associates
Concord, North Carolina, 28025, United States
Veterans Affairs Medical Center - Durham
Durham, North Carolina, 27705, United States
Duke Comprehensive Cancer Center
Durham, North Carolina, 27710, United States
Cape Fear Valley Health System
Fayetteville, North Carolina, 28302-2000, United States
Lenoir Memorial Hospital Cancer Center
Kinston, North Carolina, 28503-1678, United States
FirstHealth Moore Regional Hospital
Pinehurst, North Carolina, 28374, United States
New Hanover Regional Medical Center
Wilmington, North Carolina, 28402-9025, United States
CCOP - Southeast Cancer Control Consortium
Winston-Salem, North Carolina, 27104-4241, United States
Comprehensive Cancer Center at Wake Forest University
Winston-Salem, North Carolina, 27157-1082, United States
Veterans Affairs Medical Center - Fargo
Fargo, North Dakota, 58102, United States
CCOP - Merit Care Hospital
Fargo, North Dakota, 58122, United States
Veterans Affairs Medical Center - Cincinnati
Cincinnati, Ohio, 45220-2288, United States
Charles M. Barrett Cancer Center at University Hospital
Cincinnati, Ohio, 45267-0501, United States
MetroHealth Medical Center
Cleveland, Ohio, 44109, United States
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio, 44195-9001, United States
CCOP - Columbus
Columbus, Ohio, 43206, United States
Arthur G. James Cancer Hospital - Ohio State University
Columbus, Ohio, 43210-1240, United States
Veterans Affairs Medical Center - Dayton
Dayton, Ohio, 45428-1002, United States
CCOP - Dayton
Dayton, Ohio, 45429, United States
Oklahoma University Medical Center at University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104, United States
Veterans Affairs Medical Center - Oklahoma City
Oklahoma City, Oklahoma, 73104, United States
Cancer Institute at Oregon Health and Science University
Portland, Oregon, 97201-3098, United States
Veterans Affairs Medical Center - Portland
Portland, Oregon, 97207, United States
CCOP - Columbia River Oncology Program
Portland, Oregon, 97225, United States
CCOP - Geisinger Clinic and Medical Center
Danville, Pennsylvania, 17822-2001, United States
Penn State Cancer Institute at Milton S. Hershey Medical Center
Hershey, Pennsylvania, 17033-0850, United States
Western Pennsylvania Hospital
Pittsburgh, Pennsylvania, 15224, United States
Hillman Cancer Center at University of Pittsburgh Cancer Institute
Pittsburgh, Pennsylvania, 15236, United States
CCOP - MainLine Health
Wynnewood, Pennsylvania, 19096, United States
Lifespan: The Miriam Hospital
Providence, Rhode Island, 02906, United States
Veterans Affairs Medical Center - Charleston
Charleston, South Carolina, 29401-5799, United States
Hollings Cancer Center at Medical University of South Carolina
Charleston, South Carolina, 29425, United States
CCOP - Greenville
Greenville, South Carolina, 29615, United States
CCOP - Upstate Carolina
Spartanburg, South Carolina, 29303, United States
CCOP - Sioux Community Cancer Consortium
Sioux Falls, South Dakota, 57104, United States
University of Tennessee Cancer Institute
Memphis, Tennessee, 38103, United States
Danville Radiation Therapy Center
Memphis, Tennessee, 38104, United States
Harrington Cancer Center
Amarillo, Texas, 79106, United States
Veterans Affairs Medical Center - Amarillo
Amarillo, Texas, 79106, United States
Veterans Affairs Medical Center - Dallas
Dallas, Texas, 75216, United States
Medical City Dallas Hospital
Dallas, Texas, 75230, United States
Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas
Dallas, Texas, 75390, United States
Brooke Army Medical Center
Fort Sam Houston, Texas, 78234-6200, United States
University of Texas Medical Branch
Galveston, Texas, 77555-0565, United States
University of Texas - MD Anderson Cancer Center
Houston, Texas, 77030-4095, United States
Veterans Affairs Medical Center - Houston
Houston, Texas, 77030, United States
University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78229-3900, United States
Veterans Affairs Medical Center - San Antonio (Murphy)
San Antonio, Texas, 78229, United States
Veterans Affairs Medical Center - Temple
Temple, Texas, 76504, United States
CCOP - Scott and White Hospital
Temple, Texas, 76508, United States
Huntsman Cancer Institute
Salt Lake City, Utah, 84112-5550, United States
Veterans Affairs Medical Center - Salt Lake City
Salt Lake City, Utah, 84148, United States
Green Mountain Oncology Group
Bennington, Vermont, 05201, United States
Vermont Cancer Center at University of Vermont
Burlington, Vermont, 05401-3498, United States
Veterans Affairs Medical Center - White River Junction
White River Junction, Vermont, 05009, United States
Martha Jefferson Hospital
Charlottesville, Virginia, 22902, United States
Virginia Oncology Associates - Norfolk
Norfolk, Virginia, 23502, United States
MBCCOP - Massey Cancer Center
Richmond, Virginia, 23298-0037, United States
Oncology and Hematology Associates of Southwest Virginia, Inc.
Roanoke, Virginia, 24014, United States
CCOP - Virginia Mason Research Center
Seattle, Washington, 98101, United States
Veterans Affairs Medical Center - Seattle
Seattle, Washington, 98108, United States
Puget Sound Oncology Consortium
Seattle, Washington, 98109, United States
CCOP - Northwest
Tacoma, Washington, 98405-0986, United States
Madigan Army Medical Center
Tacoma, Washington, 98431-5000, United States
St. Mary's Medical Center
Huntington, West Virginia, 25701, United States
CCOP - St. Vincent Hospital Cancer Center, Green Bay
Green Bay, Wisconsin, 54307-3453, United States
University of Wisconsin Comprehensive Cancer Center
Madison, Wisconsin, 53792-0001, United States
CCOP - Marshfield Clinic Research Foundation
Marshfield, Wisconsin, 54449, United States
Ministry Medical Group - Northern Region
Rhinelander, Wisconsin, 54501, United States
McGill University
Montreal, Quebec, H2W 1S6, Canada
University of Puerto Rico School of Medicine Medical Sciences Campus
San Juan, 00936-5067, Puerto Rico
Pretoria Academic Hospital
Pretoria, 0001, South Africa
Related Publications (7)
Dewald GW, Paietta E, Goloubeva O, et al.: Correlation of interphase fluorescence in situ hybridization (FISH) anomalies with cell morphology and immunophenotyping in chronic lymphocytic leukemia (B-CLL). [Abstract] Blood 100 (11 pt 1): A-2334, 2002.
BACKGROUNDFlinn IW, Neuberg DS, Grever MR, Dewald GW, Bennett JM, Paietta EM, Hussein MA, Appelbaum FR, Larson RA, Moore DF Jr, Tallman MS. Phase III trial of fludarabine plus cyclophosphamide compared with fludarabine for patients with previously untreated chronic lymphocytic leukemia: US Intergroup Trial E2997. J Clin Oncol. 2007 Mar 1;25(7):793-8. doi: 10.1200/JCO.2006.08.0762. Epub 2007 Feb 5.
PMID: 17283364RESULTGrever MR, Lucas DM, Dewald GW, Neuberg DS, Reed JC, Kitada S, Flinn IW, Tallman MS, Appelbaum FR, Larson RA, Paietta E, Jelinek DF, Gribben JG, Byrd JC. Comprehensive assessment of genetic and molecular features predicting outcome in patients with chronic lymphocytic leukemia: results from the US Intergroup Phase III Trial E2997. J Clin Oncol. 2007 Mar 1;25(7):799-804. doi: 10.1200/JCO.2006.08.3089. Epub 2007 Feb 5.
PMID: 17283363RESULTByrd JC, Gribben JG, Peterson BL, Grever MR, Lozanski G, Lucas DM, Lampson B, Larson RA, Caligiuri MA, Heerema NA. Select high-risk genetic features predict earlier progression following chemoimmunotherapy with fludarabine and rituximab in chronic lymphocytic leukemia: justification for risk-adapted therapy. J Clin Oncol. 2006 Jan 20;24(3):437-43. doi: 10.1200/JCO.2005.03.1021. Epub 2005 Dec 12.
PMID: 16344317RESULTFlinn IW, Kumm E, Grever MR, et al.: Fludarabine and cyclophosphamide produces a higher complete response rate and more durable remissions than fludarabine in patients with previously untreated CLL: Intergroup trial E2997. [Abstract] Blood 104 (11): A-475, 2004.
RESULTGrever MR, Lucas DM, Dewald GW, et al.: Outcome of treatment with fludarabine versus fludarabine and cyclophosphamide in chronic lymphocytic leukemia (CLL) is adversely impacted by high risk genetic features: results from ECOG 2997. [Abstract] Blood 104 (11 Pt 1): A-3487, 2004.
RESULTLucas DM, Ruppert AS, Lozanski G, Dewald GW, Lozanski A, Claus R, Plass C, Flinn IW, Neuberg DS, Paietta EM, Bennett JM, Jelinek DF, Gribben JG, Hussein MA, Appelbaum FR, Larson RA, Moore DF Jr, Tallman MS, Byrd JC, Grever MR. Cytogenetic prioritization with inclusion of molecular markers predicts outcome in previously untreated patients with chronic lymphocytic leukemia treated with fludarabine or fludarabine plus cyclophosphamide: a long-term follow-up study of the US intergroup phase III trial E2997. Leuk Lymphoma. 2015;56(11):3031-7. doi: 10.3109/10428194.2015.1023800. Epub 2015 Mar 30.
PMID: 25721902DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Ian W. Flinn, MD, PhD
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- STUDY CHAIR
Michael R. Grever, MD
Ohio State University Comprehensive Cancer Center
- STUDY CHAIR
Mohamad A. Hussein, MD
The Cleveland Clinic
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Sponsor Type
- NETWORK
Study Record Dates
First Submitted
November 1, 1999
First Posted
January 27, 2003
Study Start
March 9, 2000
Primary Completion
November 1, 2005
Last Updated
June 18, 2023
Record last verified: 2023-06